Advance in Treatment of Chronic Lymphocytic Leukemia

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 198

Special Issue Editor


E-Mail Website
Guest Editor
RCSI & Beaumont Hospital, Dublin, Ireland
Interests: CLL; P53; Richter’s transformation

Special Issue Information

Dear Colleagues,

In the last decade we have seen a paradigm shift in the treatment of Chronic Lymphocytic leukemia. While the old standards of care of purine-analogue-based chemoimmunotherapy produced durable and, on occasion, lifelong disease control, the management of relapsed disease and high-risk patients with p53 abnormalities remained disappointing. The advent of targeted treatment of the B cell receptor and BCL-2 has revolutionized the efficacy and tolerability of treatment in this frequently older patient cohort with comorbidities and largely leveled the playing field in those with high-risk disease and consequently has replaced chemoimmunotherapy in front line and relapsed disease. We can also hopefully look forward to the next advances in treatment such as Bi-specific antibody treatments for the yet challenging patient group Richter’s transformation and third-generation BTK inhibitors for ‘double refractory’ CLL.

Dr. Patrick D. Thornton
Guest Editor

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Keywords

  • CLL
  • Richter’s transformation
  • BTK inhibitors
  • BCL2
  • Bi-specific antibodies
  • CAR-T cell

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Published Papers

This special issue is now open for submission.
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