Enzyme-Based Biosensors and Applications
A special issue of Fermentation (ISSN 2311-5637). This special issue belongs to the section "Microbial Metabolism, Physiology & Genetics".
Deadline for manuscript submissions: closed (31 October 2017) | Viewed by 187
Special Issue Editor
Interests: recombinant enzyme production; maturation of enzyme complexes; metabolic engineering; hydogen-based biotechnology
Special Issue Information
Dear Colleagues,
The monitoring of biotechnological processes using suitable online analytical methods still represents a technological challenge nowadays. The potential of these developments, however, is nowhere more apparent than in the DNA sequencing, where units of mobile phone size at a price of less than €1,000 can be used today. By combining advanced microchips with intelligent microelectronics and microfluidics, and the unique selectivity of enzymes, multiple parameters of fermentation processes are accessible at the same time by “lab-on-a-chip”-technologies. The direct and simultaneous measurement of various substrate and product concentrations allows to respond to process changes or product quality variations immediately. The description of fermentation courses with until now unmatched temporal resolution provides contemporary information about the state of the process and permits responses to faults. This facilitates customizing ongoing fermentations for optimum results. Scientific and technological challenges in the development of enzyme-based biosensors are essentially defined by the required specificity and stability of the enzymes, compatible enzyme test designs, enzyme immobilization on surfaces, the development of suitable sensor chips with integrated microfluidics and the validation of the biosensors in real life. Decisions as to which of these components are to prioritize during the stages of sensor development further influences the overall management of such endeavors, and directly affects early implementation of novel analytical techniques in the industry. The Special Issue will focus on recent developments of enzyme-based biosensors for bioprocess monitoring in fermentations that reflect one or more of these themes.
Prof. Dr. Thorsten Selmer
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Fermentation is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- biosensors
- enzymes
- microfluidics
- enzyme immobilization
- multi-parameter sensor chips
- online monitoring
- fermentation
- process optimization
- metabolism
