Molecular Insights to Improve Outcomes of Pregnancy Complications

Dear Colleagues,

Pregnancy-related complications are specific to both short- and long-term women’s health, but can also affect the offspring. Hypertensive disorders in pregnancy (HDPs) including preeclampsia and gestational hypertension are still the leading cause of death and are currently on the rise due to increasing maternal age and body max index. Both pre-gestational and gestational diabetes mellitus (GDM) can increase the risk of HDPs and predispose pregnant individuals and their offspring to long-term metabolic and cardiovascular diseases. Nevertheless, HDPs, particularly preeclampsia, are lacking effective and personalised diagnostic and therapeutic options. As part of this topic, we are inviting review, methodology and research manuscripts that describe the work related to molecular diagnostic, pathological mechanisms and therapeutic strategies for pregnancy complications including but not limited to preeclampsia, eclampsia, HELLP syndrome, chronic hypertension, gestational hypertension, pre-gestational diabetes and GDM. Existing and new biomarkers and treatments that reflect or target dysfunctional placenta, respectively, are of particular interest. New molecular insights related to placental development/biology, disease mechanisms and therapeutic targets, and improvement in treatment response are strongly encouraged.

Dr. Lana McClements
Guest Editor

Manuscript Submission Information

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• biomarkers
• diagnostics
• preeclampsia
• HDP
• placenta
• GDM