Molecular Insights into Age-Associated Diseases

Dear Colleagues,

Age is a major factor in the development of many diseases, and, thus, age-related diseases are becoming an increasingly serious public health problem. Recent data from in vitro and clinical studies show that the defectiveness of the immune system increases the risk of cancers and neurodegerenerative disease, enhances the development of sarcopenia and fraility syndrome, influences endothelial dysfunction, contributing to both microvascular (diabetic nephropathy, neuropathy, and retinopathy) and macrovascular (coronary artery disease, peripheral arterial disease, and stroke) diseases associated with old age. Furthermore, aging is related to a chronic low-grade inflammatory state in which macrophage, neutrophils, natural killer cells, and T and B lymphocytes are major effectors of immune-mediated cell responses. This inflammatory state can result from the establishment of chronic oxidative stress by immune system activity. Although modern medicine has promoted human health and greatly extended life expectancy, with the aging of society, age-related diseases have gradually become the most important causes of disability and death in elderly individuals.

This special issue is supervised by Prof. Dr. Agnieszka Zembroń-Łacny and assisted by our Topical Advisory Panel Member Prof. Dr. Agnieszka Zembroń-Łacny (University of Zielona Gora).

Dr. Agnieszka Zembrón-Łacny
Guest Editor

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• biomarkers of aging
• brain cancers
• cardiovascular diseases
• immune system diseases
• metabolic diseases
• musculoskeletal diseases
• neurodegenerative diseases