50 Years of Monoclonal Antibodies: How They Shaped Research and Medicine
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (28 February 2024) | Viewed by 243
Special Issue Editor
Interests: systemic lupus erythematosus; vasculitis; atherosclerosis; cell death; inflammation; innate immunity
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In 1973, Jerrold Schwaber and Edward Cohen developed a method of producing antibodies that involved human–mouse hybrid cells, known as hybridomas. César Milstein and Georges Köhler extended this work in 1975 by introducing polyethylene glycol (PEG) to enhance the technique's efficiency, which led to the development of monoclonal antibodies (MAbs) and earned them the Nobel Prize in Medicine in 1984.
Monoclonal antibodies (MAbs) are important tools in scientific research, and they have numerous applications across various fields of study. They can be used to identify the presence of proteins, purify target proteins, analyze cell types in blood/tissue, or isolate cells by flow cytometry.
Antibody drugs have already revolutionized the field of medicine, and they continue to be critical tools for treating various diseases. Antibody drugs were initially developed for cancer treatment; later, their use has expanded to other fields, such as immunology, infectious diseases, and neurodegenerative diseases.
With this Special Issue, readers can explore how monoclonal antibody technology has shaped research and medicine over the past 50 years. It will discuss the challenges faced by scientists in developing this technology, its impact on medical treatments, and its potential applications in the future. Original research papers and comprehensive reviews that report discoveries or medical applications focused on mAbs are welcome. Historical essays on mAbs will also be considered.
Prof. Dr. Hajime Kono
Guest Editor
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Keywords
- hybridoma
- monoclonal antibody
- antibody drug
- biological medical product
- engineered antibodies
