Advanced Molecular Mechanisms and Technologies in Cardiac Regeneration

Dear Colleagues,

Ischemic heart disease continues to be a major cause of morbidity and mortality globally. A tremendous amount of research has been focused on recovering cardiac function post-ischemic injury, but there has yet to be a clinically approved therapy that can restore the structural and contractile function at an infarction site. In cases of resulting heart failure, heart transplantation remains to be the only intervention that can attain full cardiac function post-injury. With the global shortage of donor hearts, cardiac regenerative therapies are in urgent clinical demand.

Exciting developments in gene-editing, stem cell biology, single cell transcriptomics, 3D microtissues, and cell-free therapies have greatly increased our understanding of the mechanisms involved in cardiac damage and repair. Here, we would like to highlight how the application of these mechanisms and technologies can be used to regenerate cardiac tissue post-injury.

In this Special Issue, we would like to invite researchers who focus on the latest molecular advances in cardiac regeneration that may aid in shaping clinical translation of tomorrow’s therapies.

Original research articles, perspectives, mini-reviews, as well as comprehensive reviews are welcome.

Dr. Marcy Martin
Guest Editor

Manuscript Submission Information

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• cardiac regeneration
• gene-editing
• cellular reprogramming
• multi-omics
• personalized medicine
• clinical translation