Pathology of Gliomas
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 15 May 2024 | Viewed by 236
Special Issue Editors
Interests: glioma anti-cancer therapeutics; glioma biomarkers; molecular-targeted magnetic resonance imaging; preclinical models; clinical translation; in-silico predicted biomarkers
Interests: neuro-oncology; glioma anti-cancer therapeutics; tumor cell migration; clinical trials; preclinical models; glioma pathology
Special Issue Information
Dear Colleagues,
Gliomas vary in their pathological characteristics due to their heterogeneous nature. Adult and pediatric gliomas differ dramatically in their pathological origins. Adult-type diffuse gliomas are differentiated on the presence of an isocitrate deydrogenase 1 (IDH1) mutation, 1p/19q-codeletion, and histological grades. In contrast, aberrations of the mitogen-activated protein kinase pathway in low-grade gliomas, and the presence of histone H3 K27M mutations in diffuse intrinsic pontine and other midline gliomas, are used to differentiate pediatric gliomas. Bioinformatics has provided new insights to potential biomarker targets for gliomas, which may aid in therapeutic interventions. This review will focus on the current pathological characteristics of adult and pediatric gliomas, and touch on some novel therapeutic targets based on recent gene discoveries.
Dr. Rheal Towner
Dr. James Battiste
Guest Editors
Manuscript Submission Information
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Keywords
- adult and pediatric gliomas
- in-silico predicted biomarkers for gliomas
- genetic heterogeneity
- histological grades
- molecular-targeted molecular imaging
