Editor’s Choice Articles

The agriculture sector in Poland could provide 7.8 billion m³ of biogas per year, but this potential would be from dispersed plants of a low capacity. In the current study, a membrane process was investigated for the upgrading biogas to biomethane that conforms to the requirements for grid gas in Poland. It was assumed that such a process is based on membranes made from modified polysulfone or polyimide, available in the market in Air Products PRISM PA1020 and UBE UMS-A5 modules, respectively. The case study has served an agricultural biogas plant in southern Poland, which provides the stream of 5 m³ (STP) h⁻¹ of biogas with a composition of CH₄ (52 vol.%), CO₂ (46.3 vol.%), N₂ (1.6 vol.%) and O₂ (0.1 vol.%), after a pretreatment. It was theoretically shown that this is possible to obtain the biomethane stream of at least 96 vol.% of CH₄ purity, with the concentration of the other biogas components below their respective thresholds, as required in Poland for gas fuel “E”, with methane recovery of up to 87.5% and 71.6% for polyimide and polysulfone membranes, respectively. The energetic efficiency of the separation process is comparable for both membrane materials, as expressed by power excess index, which reaches up to 51.3 kW_th kW_el⁻¹ (polyimide) and 40.7 kW_th kW_el⁻¹ (polysulfone). In turn, the membrane productivity was significantly higher in the case of the polyimide membrane (up to 38.3 kW_th m⁻²) than those based on the polysulfone one (up to 3.13 kW_th m⁻²). Full article

Membrane fouling has been one of the most important challenges in membrane separation operations. In this study, we report a facile strategy to prepare antifouling polysulfone (PSf) UF membranes by blending amphiphilic zwitterion polysulfone-co-sulfobetaine polysulfone (PSf-co-SBPSf) copolymer. The copolymer chemical structure was characterized by ¹HNMR spectroscopy. The PSf/PSf-co-SBPSf blend membranes with various zwitterionic SBPSf segment contents exhibited better surface hydrophilicity and excellent antifouling ability compared to PSf and PSf/PEG membranes. The significant increase of both porosity and water permeance indicates that the PSf-co-SBPSf has a pore-forming effect. The pure water flux and flux recovery ratio of the PSf/PSf-co-SBPSf blend membranes were both remarked to improve 286.43 L/m²h and 92.26%, while bovine serum albumin (BSA) rejection remained at a high level (97.66%). More importantly, the water flux and BSA rejection see minimal variance after heat treatment, indicating excellent thermostability. Overall, the PSf/PSf-co-SBPSf blend membranes achieved a comprehensive performance of sustainable hydrophilic, high permeation flux, and remarkable antifouling ability, thus becoming a promising candidate in high-temperature separation application. Full article

Thin pure-silica chabazite (Si-CHA) membranes have been synthesized by using a secondary growth method on a porous silica substrate. A CO₂ permeance of 2.62 × 10⁻⁶ mol m⁻² s⁻¹ Pa⁻¹ with a CO₂/CH₄ permeance ratio of 62 was obtained through a Si-CHA membrane crystallized for 8 h using a parent gel of H₂O/SiO₂ ratio of 4.6. The CO₂ permeance through the Si-CHA membrane on a porous silica substrate was twice as high as that through the membrane synthesized on a porous alumina substrate, which displayed a similar zeolite layer thickness. Full article

Like protein phosphorylation, O-GlcNAcylation is a common post-translational protein modification. We already reported that O-GlcNAcylation of amyloid precursor protein (APP) in response to insulin signaling reduces neurotoxic amyloid-β (Aβ) production via inhibition of APP endocytosis. Internalized APP is delivered to endosomes and lysosomes where Aβ is produced. However, the molecular mechanism involved in the effect of APP O-GlcNAcylation on APP trafficking remains unknown. To investigate the relationship between APP O-GlcNAcylation and APP endocytosis, we tested the effects of insulin on neuroblastoma SH-SY5Y cells overexpressing APP and BACE1, and cultured rat hippocampal neurons. The present study showed that APP O-GlcNAcylation translocated APP from lipid raft to non-raft microdomains in the plasma membrane by using immunocytochemistry and discontinuous sucrose gradients method. By using the biotinylation method, we also found that APP preferentially underwent endocytosis from lipid rafts and that the amount of internalized APP from lipid rafts was specifically reduced by O-GlcNAcylation. These results indicate that O-GlcNAcylation can regulate lipid raft-dependent APP endocytosis via translocation of APP into non-raft microdomains. Our findings showed a new functional role of O-GlcNAcylation for the regulation of APP trafficking, offering new mechanistic insight for Aβ production. Full article

Hydrophobic membranes were characterized at elevated temperatures. Pressure was applied at the feed and permeate side to ensure liquid phase conditions. Within this scope, the applicability of different polymeric and ceramic membranes in terms of liquid entry pressure was studied using water. The Visual Method and the Pressure Step Method were applied for the experimental investigation. The results show the Pressure Step Method to be an early detection method. The tests at higher pressure and temperature conditions using the Pressure Step Method revealed the temperature as being the main factor affecting the liquid entry pressure. Novel LEP data up to 120 °C and 2.5 bar were obtained, which broadens the application range of hydrophobic membranes. Full article

Imidazoline is a five-membered heterocycle derived by the partial reduction of one double bond of the imidazole ring. This work prepared new anion exchange membranes (AEMs) based on imidazoline quaternized polystyrene copolymers bearing N-b-hydroxyethyl oleyl imidazolinium pendent groups to evaluate the application potential for anion exchange membrane fuel cells (AEMFCs). For comparison, an imidazole quaternized polystyrene copolymer was also synthesized. The polymer chemical structure was confirmed by FTIR, NMR, and TGA. In addition, the essential properties of membranes, including ion exchange capacity (IEC), water uptake, and hydroxide conductivity, were measured. The alkaline stabilities of imidazolium-based and imidazolinium-based AEMs were compared by means of the changes in the TGA thermograms, FTIR spectra, and hydroxide conductivity during the alkaline treatment in 1 M KOH at 60 °C for 144 h. The results showed that the imidazolinium-based AEMs exhibited relatively lower hydroxide conductivity (5.77 mS/cm at 70 °C) but much better alkaline stability compared with the imidazolium-based AEM. The imidazolinium-based AEM (PSVBImn-50) retained 92% of its hydroxide conductivity after the alkaline treatment. Besides, the fuel cell performance of the imidazolium-based and imidazolinium-based AEMs was examined by single-cell tests. Full article

Hollow fiber nanofiltration (NF) membranes have gained increased attention in recent years, partly driven by the availability of alternatives to polyamide-based dense separation layers. Moreover, the global market for NF has been growing steadily in recent years and is expected to grow even faster. Compared to the traditional spiral-wound configuration, the hollow fiber geometry provides advantages such as low fouling tendencies and effective hydraulic cleaning possibilities. The alternatives to polyamide layers are typically chemically more stable and thus allow operation and cleaning at more extreme conditions. Therefore, these new NF membranes are of interest for use in a variety of applications. In this review, we provide an overview of the applications and emerging opportunities for these membranes. Next to municipal wastewater and drinking water processes, we have put special focus on industrial applications where hollow fiber NF membranes are employed under more strenuous conditions or used to recover specific resources or solutes. Full article

Membrane filtration is considered to be one of the most promising methods for oily wastewater treatment. Because of their hydrophilic surface, ceramic membranes show less fouling compared with their polymeric counterparts. Membrane fouling, however, is an inevitable phenomenon in the filtration process, leading to higher energy consumption and a shorter lifetime of the membrane. It is therefore important to improve the fouling resistance of the ceramic membranes in oily wastewater treatment. In this review, we first focus on the various methods used for ceramic membrane modification, aiming for application in oily wastewater. Then, the performance of the modified ceramic membranes is discussed and compared. We found that, besides the traditional sol-gel and dip-coating methods, atomic layer deposition is promising for ceramic membrane modification in terms of the control of layer thickness, and pore size tuning. Enhanced surface hydrophilicity and surface charge are two of the most used strategies to improve the performance of ceramic membranes for oily wastewater treatment. Nano-sized metal oxides such as TiO₂, ZrO₂ and Fe₂O₃ and graphene oxide are considered to be the potential candidates for ceramic membrane modification for flux enhancement and fouling alleviation. The passive antifouling ceramic membranes, e.g., photocatalytic and electrified ceramic membranes, have shown some potential in fouling control, oil rejection and flux enhancement, but have their limitations. Full article

Cellular communications take place thanks to a well-connected network of chemical–physical signals, biomolecules, growth factors, and vesicular messengers that travel inside or between cells. A deep knowledge of the extracellular vesicle (EV) system allows for a better understanding of the whole series of phenomena responsible for cell proliferation and death. To this purpose, here, a thorough immuno-phenotypic characterization of B-cell EV membranes is presented. Furthermore, the cellular membrane of B lymphocytes, Burkitt lymphoma, and human myeloid leukemic cells were characterized through cytofluorimetry assays and fluorescent microscopy analysis. Through cytotoxicity and internalization tests, the tropism of B lymphocyte-derived EVs was investigated toward the parental cell line and two different cancer cell lines. In this study, an innate capability of passive targeting of the native EVs was distinguished from the active targeting capability of monoclonal antibody-engineered EVs, able to selectively drive the vesicles, enhancing their internalization into the target cancer cells. In particular, the specific targeting ability of anti-CD20 engineered EVs towards Daudi cells, highly expressing CD20 marker on their cell membrane, was proved, while almost no internalization events were observed in HL60 cells, since they did not express an appreciable amount of the CD20 marker on their plasma membranes. Full article

In this paper, the composition, function and structure of the catalyst layer (CL) of a proton exchange membrane fuel cell (PEMFC) are summarized. The hydrogen reduction reaction (HOR) and oxygen reduction reaction (ORR) processes and their mechanisms and the main interfaces of CL (PEM|CL and CL|MPL) are described briefly. The process of mass transfer (hydrogen, oxygen and water), proton and electron transfer in MEA are described in detail, including their influencing factors. The failure mechanism of CL (Pt particles, CL crack, CL flooding, etc.) and the degradation mechanism of the main components in CL are studied. On the basis of the existing problems, a structure optimization strategy for a high-performance CL is proposed. The commonly used preparation processes of CL are introduced. Based on the classical drying theory, the drying process of a wet CL is explained. Finally, the research direction and future challenges of CL are pointed out, hoping to provide a new perspective for the design and selection of CL materials and preparation equipment. Full article

Gas-permeable membrane (GPM) technology is a possible solution to reduce ammonia (NH₃) emissions from livestock housing. This paper presents the results obtained with an NH₃-capture prototype based on the use of expanded polytetrafluoroethylene (ePTFE) membranes in real conditions in a gestating sow house and a free-range laying hen house, comparing them with the results obtained in controlled laboratory conditions for the same type of waste. The NH₃ present in the air of the livestock housing was captured by reaction with an acidic solution flowing inside the membranes. The periods of continuous operation of the pilot plant were 232 days at the pig farm and 256 days at the poultry farm. The NH₃ recovery rate at the end of those periods was 2.3 and 0.4 g TAN·m⁻²·d⁻¹ in the pig and the poultry farms, respectively. The limiting factor for the capture process was the NH₃ concentration in the air, with the highest recovery occurring in the most concentrated atmosphere. Differences in NH₃ capture were observed between seasons and farms, with capture efficiencies of 1.62 and 0.33 g·m⁻²·d⁻¹ in summer and 3.85 and 1.20 g·m⁻²·d⁻¹ in winter for pig and poultry farms, respectively. The observed differences were mainly due to the higher ventilation frequency in the summer months, which resulted in a lower NH₃ concentration inside the houses compared to the winter months. This is especially important when considering the real applicability of this technology. The results obtained suggest that GPM technology holds promise for limiting NH₃ emissions from livestock housing with NH₃ ambient concentrations close to 20 ppm or as part of manure storage facilities, given that it allows for recovery of nitrogen in a stable and concentrated solution, which can be used as a fertilizer. Full article

Ion channels are membrane proteins that play important roles in a wide range of fundamental cellular processes. Studying membrane proteins at a molecular level becomes challenging in complex cellular environments. Instead, many studies focus on the isolation and reconstitution of the membrane proteins into model lipid membranes. Such simpler, in vitro, systems offer the advantage of control over the membrane and protein composition and the lipid environment. Rhodopsin and rhodopsin-like ion channels are widely studied due to their light-interacting properties and are a natural candidate for investigation with fluorescence methods. Here we review techniques for synthesizing liposomes and for reconstituting membrane proteins into lipid bilayers. We then summarize fluorescence assays which can be used to verify the functionality of reconstituted membrane proteins in synthetic liposomes. Full article

Mechanosensitive channels respond to mechanical forces exerted on the cell membrane and play vital roles in regulating the chemical equilibrium within cells and their environment. High-resolution structural information is required to understand the gating mechanisms of mechanosensitive channels. Protein-lipid interactions are essential for the structural and functional integrity of mechanosensitive channels, but detergents cannot maintain the crucial native lipid environment for purified mechanosensitive channels. Recently, detergent-free systems have emerged as alternatives for membrane protein structural biology. This report shows that while membrane-active polymer, SMA2000, could retain some native cell membrane lipids on the transmembrane domain of the mechanosensitive-like YnaI channel, the complete structure of the transmembrane domain of YnaI was not resolved. This reveals a significant limitation of SMA2000 or similar membrane-active copolymers. This limitation may come from the heterogeneity of the polymers and nonspecific interactions between the polymers and the relatively large hydrophobic pockets within the transmembrane domain of YnaI. However, this limitation offers development opportunities for detergent-free technology for challenging membrane proteins. Full article

Electrofiltration, an electric field-assisted membrane process, has been a research topic of growing popularity due to its ability to improve membrane performance by providing in situ antifouling conditions in a membrane system. The number of reports on electrofiltration have increased exponentially over the past two decades. These reports explored many innovations, such as novel configurations of an electric field, engineered membrane materials, and interesting designs of foulant compositions and membrane modules. Recent electrofiltration literature focused mainly on compiling results without a comprehensive comparative analysis across different works. The main objective of this critical review is to, first, organize, compare and contrast the results across various electrofiltration studies; second, discuss various types of mechanisms that could be incorporated into electrofiltration and their effect on membrane system performance; third, characterize electrofiltration phenomenon; fourth, interpret the effects of various operational conditions on the performance of electrofiltration; fifth, evaluate the state-of-the-art knowledge associated with modeling efforts in electrofiltration; sixth, discuss the energy costs related to the implementation of electrofiltration; and finally, identify the current knowledge gaps that hinder the transition of the lab-scale observations to industry-scale electrofiltration as well as the future prospects of electrofiltration. Full article

Herein, a novel form of bicomponent nanofiber membrane containing stereo-complex polylactic acid (SC-PLA) was successfully produced by the side-by-side electrospinning of Poly (L-lactic acid) (PLLA) and Poly (D-lactic acid) (PDLA). We demonstrate that through these environmentally sustainable materials, highly efficient nanofiber assemblies for filtration can be constructed at very low basis weight. The physical and morphological structure, crystalline structure, hydrophobicity, porous structure, and filtration performance of the fibrous membranes were thoroughly characterized. It was shown that the fabricated polylactic acid (PLA) side-by-side fiber membrane had the advantages of excellent hydrophobicity, small average pore size, high porosity, high filtration efficiency, low pressure drop as well as superior air permeability. At the very low basis weight of 1.1 g/m², the filtration efficiency and pressure drop of the prepared side-by-side membrane reached 96.2% and 30 Pa, respectively. Overall, this biomass-based, biodegradable filtration material has the potential to replace the fossil fuel-based polypropylene commercial meltblown materials for the design and development in filtration, separation, biomedical, personal protection and other fields. Full article

A novel cellulose acetate-based monophasic hybrid skinned amine-functionalized CA-SiO₂-(CH₂)₃NH₂ membrane was synthesized using an innovative method which combines the phase inversion and sol-gel techniques. Morphological characterization was performed by scanning electron microscopy (SEM), and the chemical composition was analyzed by Fourier transform infrared spectroscopy in attenuated total reflection mode (ATR-FTIR). The characterization of the monophasic hybrid CA-SiO₂-(CH₂)₃NH₂ membrane in terms of permeation properties was carried out in an in-house-built single hemodialysis membrane module (SHDMM) under dynamic conditions. Permeation experiments were performed to determine the hydraulic permeability (Lp), molecular weight cut-off (MWCO) and the rejection coefficients to urea, creatinine, uric acid, and albumin. SEM confirmed the existence of a very thin (<1 µm) top dense layer and a much thicker bottom porous surface, and ATR-FTIR showed the main bands belonging to the CA-based membranes. Permeation studies revealed that the Lp and MWCO of the CA-SiO₂-(CH₂)₃NH₂ membrane were 66.61 kg·h⁻¹·m⁻²·bar⁻¹ and 24.5 kDa, respectively, and that the Lp was 1.8 times higher compared to a pure CA membrane. Furthermore, the CA-SiO₂-(CH₂)₃NH₂ membrane fully permeated urea, creatinine, and uric acid while completely retaining albumin. Long-term filtration studies of albumin solutions indicated that fouling does not occur at the surface of the CA-SiO₂-(CH₂)₃NH₂ membrane. Full article

Ion-exchange membranes (IEMs) are increasingly used in dialysis and electrodialysis processes for the extraction, fractionation and concentration of valuable components, as well as reagent-free control of liquid media pH in the food industry. Fouling of IEMs is specific compared to that observed in the case of reverse or direct osmosis, ultrafiltration, microfiltration, and other membrane processes. This specificity is determined by the high concentration of fixed groups in IEMs, as well as by the phenomena inherent only in electromembrane processes, i.e., induced by an electric field. This review analyzes modern scientific publications on the effect of foulants (mainly typical for the dairy, wine and fruit juice industries) on the structural, transport, mass transfer, and electrochemical characteristics of cation-exchange and anion-exchange membranes. The relationship between the nature of the foulant and the structure, physicochemical, transport properties and behavior of ion-exchange membranes in an electric field is analyzed using experimental data (ion exchange capacity, water content, conductivity, diffusion permeability, limiting current density, water splitting, electroconvection, etc.) and modern mathematical models. The implications of traditional chemical cleaning are taken into account in this analysis and modern non-destructive membrane cleaning methods are discussed. Finally, challenges for the near future were identified. Full article

The use of poly(vinylidene fluoride) (PVDF) microfiltration (MF) membranes to purify oily water has received much attention. However, it is challenging to obtain high-performance PVDF microfiltration membranes due to severe surface fouling and rapid decline of permeability. This study explored a new approach to fabricate high-performance PVDF/silica (SiO₂) composite membrane via the use of a polymer solution featuring lower critical solution temperature (LCST) characteristics and the non-solvent thermally induced phase separation method (NTIPS). Coupling with morphological observations, the membrane formation kinetics were analyzed in depth to understand the synergistic effect between the LCST solution properties and fabrication conditions in NTIPS. Utilizing such a synergistic effect, the transition from finger-like macrovoid pores to bi-continuous highly connected pores could be flexibly tuned by increasing the PVDF concentration and the weight ratio of SiO₂/PVDF in the dope solution and by raising the coagulation temperature to above the LCST of the solution. The filtration experiments with surfactant-stabilized oil-water emulsion showed that the permeation flux of the PVDF/SiO₂ composite membranes was higher than 318 L·m⁻²·h⁻¹·bar⁻¹ and the rejection above 99.2%. It was also shown that the PVDF/SiO₂ composite membranes, especially those fabricated above the LCST, demonstrated better hydrophilicity, which resulted in significant enhancement in the anti-fouling properties for oil/water emulsion separation. Compared to the benchmark pure PVDF membrane in oily water purification, the optimal composite membrane T70 was demonstrated via the 3-cycle filtration experiments with a significantly improved flux recovery ratio (F_rr) and minimal reduced irreversible fouling (R_ir). Overall, with the developed method in this work, facile procedure to tune the membrane morphology and pore structure was demonstrated, resulting in high performance composite membranes suitable for oil/water emulsion separation. Full article

The prediction of membrane failure in full-scale water purification plants is an important but difficult task. Although previous studies employed accelerated laboratory-scale tests of membrane failure, it is not possible to reproduce the complex operational conditions of full-scale plants. Therefore, we aimed to develop prediction models of membrane failure using actual membrane failure data. Because membrane filtration systems are repairable systems, nonhomogeneous Poisson process (NHPP) models, i.e., power law and log-linear models, were employed; the model parameters were estimated using the membrane failure data from a full-scale plant operated for 13 years. Both models were able to predict cumulative failures for forthcoming years; nonetheless, the power law model showed higher stability and narrower confidence intervals than the log-linear model. By integrating two membrane replacement criteria, namely deterioration of filtrate water quality and reduction of membrane permeability, it was possible to predict the time to replace all the membranes on a water purification plant. Finally, the NHPP models coupled with a nonparametric bootstrap method provided a method to select membrane modules for earlier replacement than others. Although the criteria for membrane replacement may vary among membrane filtration plants, the NHPP models presented in this study could be applied to any other plant with membrane failure data. Full article

Processes, such as biogas upgrading and natural gas sweetening, make CO₂/CH₄ separation an environmentally relevant and current topic. One way to overcome this separation issue is the application of membranes. An increase in separation efficiency can be achieved by applying mixed-matrix membranes, in which filler materials are introduced into polymer matrices. In this work, we report the covalent triazine framework CTF-biphenyl as filler material in a matrix of the glassy polyimide Matrimid^®. MMMs with 8, 16, and 24 wt% of the filler material are applied for CO₂/CH₄ mixed-gas separation measurements. With a CTF-biphenyl loading of only 16 wt%, the CO₂ permeability is more than doubled compared to the pure polymer membrane, while maintaining the high CO₂/CH₄ selectivity of Matrimid^®. Full article

In this study, a simple method for the fabrication of highly diffusive, adsorptive and conductive eco-friendly polyelectrolyte membranes (PEMs) with sulfonate functionalized pectin and poly(vinyl alcohol)(PVA) was established. The graft-copolymers were synthesized by employing the use of potassium persulfate as a free radical initiator from pectin (PC), a carbohydrate polymer with 2-acrylamido-2-methyl-1-propanesulphonic acid (AMPS) and sodium 4-vinylbenzene sulphonate (SVBS). The PEMs were fabricated from the blends of pectin graft-copolymers (PC-g-AMPS and PC-g-SVBS) and PVA by using a solution casting method, followed by chemical crosslinking with glutaraldehyde. The composite PEMs were fabricated by mixing phosphomolybdic acid with the aforementioned blends. The PEMs were successfully characterized by FTIR, XRD, SEM, and EDAX studies. They were assessed for the controlled release of an anti-cancer drug (5-fluorouracil) and the removal of toxic metal ions (Cu²⁺) from aqueous media. Furthermore, the composite PEMs were evaluated for fuel cell application. The 5-fluorouracil release capacity of the PEMs was found to be 93% and 99.1% at 300 min in a phosphate buffer solution (pH = 7.4). The highest Cu²⁺ removal was observed at 206.7 and 190.1 mg/g. The phosphomolybdic acid-embedded PEMs showed superior methanol permeability, i.e., 6.83 × 10⁻⁵, and 5.94 × 10^−5, compared to the pristine PEMs. Furthermore, the same trend was observed for the proton conductivities, i.e., 13.77 × 10⁻³, and 18.6 × 10⁻³ S/cm at 30 °C. Full article

The present study deals with the combination of ethanol steam reforming over a monolithic catalyst and hydrogen separation by membrane in a lab-scale catalytic membrane reactor (CMR). The catalyst was comprised of honeycomb thin-walled Fechralloy substrate loaded with Ni + Ru/Pr_0.35Ce_0.35Zr_0.35O₂ active component. The asymmetric supported membrane consisted of a thin Ni-Cu alloy–Nd tungstate nanocomposite dense permselective layer deposited on a hierarchically structured asymmetric support. It has been shown that the monolithic catalyst-assisted CMR is capable of increasing the driving potential for hydrogen permeation through the same membrane as compared with that of the packed bed catalyst by increasing the retentate hydrogen concentration. Important operating parameters responsible for the low carbon deposition rate as well as the amount of hydrogen produced from 1 mol of ethanol, such as the temperature range of 700–900 °C, the water/ethanol molar ratio of 4 in the feed, have been determined. Regarding the choice of the reagent concentration (ethanol and steam in Ar), its magnitude may directly interfere with the effectiveness of the reaction-separation process in the CMR. Full article

Graphene-based membranes are promising candidates for efficient organic solvent nanofiltration (OSN) processes because of their unique structural characteristics, such as mechanical/chemical stability and precise molecular sieving. Recently, to improve organic solvent permeance and selectivity, nanopores have been fabricated on graphene planes via chemical and physical methods. The nanopores serve as an additional channel for facilitating ultrafast solvent permeation while filtering organic molecules by size exclusion. This review summarizes the recent developments in nanoporous graphene (NG)-based membranes for OSN applications. The membranes are categorized depending on the membrane structure: single-layer NG, multilayer NG, and graphene-based composite membranes hybridized with other porous materials. Techniques for nanopore generation on graphene, as well as the challenges faced and the perspectives required for the commercialization of NG membranes, are also discussed. Full article

Electrodialysis (ED) was first established for water desalination and is still highly recommended in this field for its high water recovery, long lifetime and acceptable electricity consumption. Today, thanks to technological progress in ED processes and the emergence of new ion-exchange membranes (IEMs), ED has been extended to many other applications in the food industry. This expansion of uses has also generated several problems such as IEMs’ lifetime limitation due to different ageing phenomena (because of organic and/or mineral compounds). The current commercial IEMs show excellent performance in ED processes; however, organic foulants such as proteins, surfactants, polyphenols or other natural organic matters can adhere on their surface (especially when using anion-exchange membranes: AEMs) forming a colloid layer or can infiltrate the membrane matrix, which leads to the increase in electrical resistance, resulting in higher energy consumption, lower water recovery, loss of membrane permselectivity and current efficiency as well as lifetime limitation. If these aspects are not sufficiently controlled and mastered, the use and the efficiency of ED processes will be limited since, it will no longer be competitive or profitable compared to other separation methods. In this work we reviewed a significant amount of recent scientific publications, research and reviews studying the phenomena of IEM fouling during the ED process in food industry with a special focus on the last decade. We first classified the different types of fouling according to the most commonly used classifications. Then, the fouling effects, the characterization methods and techniques as well as the different fouling mechanisms and interactions as well as their influence on IEM matrix and fixed groups were presented, analyzed, discussed and illustrated. Full article

Palladium and palladium alloy membranes are superior materials for hydrogen purification, removal, or reaction processes. Sieverts’ Law suggests that the flux of hydrogen through such membranes is proportional to the difference between the feed and permeate side partial pressures, each raised to the 0.5 power (n = 0.5). Sieverts’ Law is widely applied in analyzing the steady state hydrogen permeation through Pd-based membranes, even in some cases where the assumptions made in deriving Sieverts’ Law do not apply. Often permeation data are fit to the model allowing the pressure exponent (n) to vary. This study experimentally assessed the validity of Sieverts’ Law as hydrogen was separated from other gases and theoretically modelled the effects of pressure and temperature on the assumptions and hence the accuracy of the 0.5-power law even with pure hydrogen feed. Hydrogen fluxes through Pd and Pd-Ag alloy foils from feed mixtures (5–83% helium in hydrogen; 473–573 K; with and without a sweep gas) were measured to study the effect of concentration polarization (CP) on hydrogen permeance and the applicability of Sieverts’ Law under such conditions. Concentration polarization was found to dominate hydrogen transport under some experimental conditions, particularly when feed concentrations of hydrogen were low. All mixture feed experiments showed deviation from Sieverts’ Law. For example, the hydrogen flux through Pd foil was found to be proportional to the partial pressure difference (n ≈ 1) rather than being proportional to the difference in the square root of the partial pressures (n = 0.5), as suggested by Sieverts’ Law, indicating the high degree of concentration polarization. A theoretical model accounting for Langmuir adsorption with temperature dependent adsorption equilibrium coefficient was made and used to assess the effect of varying feed pressure from 1–136 atm at fixed temperature, and of varying temperature from 298 to 1273 K at fixed pressure. Adsorption effects, which dominate at high pressure and at low temperature, result in pressure exponents (n) values less than 0.5. With better understanding of the transport steps, a qualitative analysis of literature (n) values of 0.5, 0.5 < n < 1, and n > 1, was conducted suggesting the role of each condition or step on the hydrogen transport based on the empirically fit exponent value. Full article

This article shows the optimization of the reverse osmosis process in seawater desalination plants, taking the example of the Canary Islands, where there are more than 320 units of different sizes, both private and public. The objective is to improve the energy efficiency of the system in order to save on operation costs as well as reduce the carbon and ecological footprints. Reverse osmosis membranes with higher surface area have lower energy consumption, as well as energy recovery systems to recover the brine pressure and introduce it in the system. Accounting for the operation, maintenance and handling of the membranes is also important in energy savings, in order to improve the energy efficiency. The energy consumption depends on the permeate water quality required and the model of the reverse osmosis membrane installed in the seawater desalination plant, as it is shown in this study. Full article

The study of the effects associated with the compatibility of the components of the hybrid filler with polymer matrix, which ultimately decide on achieving mixed matrix membranes (MMMs) with better gas separation properties, is essential. Herein, a facile solution casting process of simple incorporating CeO₂@GO hybrid inorganic filler material is implemented. Significant improvements in material and physico-chemical properties of the synthesized membranes were observed by SEM, XRD, TGA, and stress-strain measurements. Usage of graphene oxide (GO) with polar groups on the surface enabled forming bonds with ceria (CeO₂) nanoparticles and CTA polymer and provided the homogeneous dispersion of the nanofillers in the hybrid MMMs. Moreover, increasing GO loading concentration enhanced both gas permeation in MMMs and CO₂ gas uptakes. The best performance was achieved by the membrane containing 7 wt.% of GO with CO₂ permeability of 10.14 Barrer and CO₂/CH₄ selectivity 50.7. This increase in selectivity is almost fifteen folds higher than the CTA-CeO₂ membrane sample, suggesting the detrimental effect of GO for enhancing the selectivity property of the MMMs. Hence, a favorable synergistic effect of CeO₂@GO hybrid fillers on gas separation performance is observed, propounding the efficient and feasible strategy of using hybrid fillers in the membrane for the potential biogas upgrading process. Full article

Water resource pollution by nitrate-nitrogen, mainly caused by anthropogenic causes, induces eutrophication of water resources, and indicates the degree of organic pollution. Therefore, this study devised a method for coating PFSA ionomer with excellent chemical resistance without disassembling the module to improve the removal rate of nitrate-nitrogen in water by using a cyclic coating method on a commercially available nanofiltration membrane (NF membrane) module. Nafion was prepared as a supercritical fluid dispersion using a high-temperature and high-pressure reactor, and the particle size and the degree of dispersion of the dispersion were analyzed by DLS. The crystallinity was confirmed through XRD by drying the dispersion in the liquid state. After the dispersion was prepared as a membrane according to the heat treatment conditions, the characteristics according to the particle size were analyzed by tensile strength and TEM. The nitrate-nitrogen removal rate of the NF membrane module coated with the dispersion was increased by 93% compared to that before coating. Therefore, the result showed that the cycle coating method devised in this study could efficiently coat the already commercialized module and improve performance. Full article

To improve membrane fouling management, the NaClO-assisted backwash has been developed to improve permeability maintenance and reduce the need for intensive chemical cleanings. This study is aimed to focus on the efficiency of NaClO-assisted backwash in real UF pilot scale and with periodic classic backwash (CB) and air backwash (AB). The impacts on hydraulic filtration performance, physicochemical properties of membrane material under different addition frequencies of NaClO, and the performance of chlorinated CB and AB will be discussed. In result, 10 mg Cl₂ L⁻¹ NaClO addition in backwash water is confirmed to greatly improve the overall filtration performance and backwash cleaning efficiency. One condition stands out from the other due to better control of irreversible fouling, less NaClO consumption in 10 years prediction, sustainable and adaptable filtration performance, and less potential damage on the physicochemical properties of the membrane. Additionally, it can be inferred from this experiment that frequent contact with NaClO induced some degradation on the PES-made UF membrane surface properties. To retain the best state of UF membrane on anti-fouling and qualified production, the optimized condition with more frequent NaClO contact was not suggested for long-term filtration. Full article

Heat pump systems can simultaneously produce cooling energy for space cooling in hotels, office and residential buildings and heat for desalination using membrane distillation (MD). The MD technique uses a heat input at a temperature compatible with the levels of heat pump condensers (<60 °C). A heat pump prototype coupled with an air-gap membrane distillation unit was constructed and tested. This paper presents the experimental study on a lab-scale prototype and details the two operating modes “continuous” and “controlled” simulating an air conditioning system and a food storage, respectively. The experimental results enable to analyze the performance of the prototype and the physical phenomena involved. Finally, the study shows that this system could be a promising solution to help supplying freshwater to people in hot regions of the world. Full article

The development of a low-cost and environmentally-friendly procedure for the fabrication of silicon carbide (SiC) membranes while achieving good membrane performance is an important goal, but still a big challenge. To address this challenge, herein, a colloidal coating suspension of sub-micron SiC powders was prepared in aqueous media by employing aluminum nitrate nonahydrate as a sintering additive and was used for the deposition of a novel SiC membrane layer onto a SiC tubular support by dip-coating. The sintering temperature influence on the structural morphology was studied. Adding aluminum nitrate nonahydrate reduced the sintering temperature of the as-prepared membrane compared to conventional SiC membrane synthesis. Surface morphology, pore size distribution, crystalline structure, and chemical and mechanical stability of the membrane were characterized. The membrane showed excellent corrosion resistance in acidic and basic medium for 30 days with no significant changes in membrane properties. The pure water permeance of the membrane was measured as 2252 L h⁻¹ m⁻² bar⁻¹. Lastly, the final membrane with 0.35 µm mean pore size showed high removal of oil droplets (99.7%) in emulsified oil-in-water with outstanding permeability. Hence, the new SiC membrane is promising for several industrial applications in the field of wastewater treatment. Full article

CO₂ capture and utilization (CCU) is a promising approach in controlling the global discharge of greenhouse gases (GHG). This study details the experimental investigation of CO₂ utilization in membrane-based water treatment systems for lowering the potential of ionic precipitation on membrane surface and subsequent scale development. The CO₂ utilization in feed water reduces the water pH that enables the dissociation of salts in their respective ions, which leave the system as a concentrate. This study compares the efficiency of CO₂ and other antifouling agents (CA-1, CA-2, and CA-3) for fouling control in four different membrane-based wastewater reclamation operations. These systems include Schemes 1, 2, 3, and 4, which were operated with CA-1, CA-2, CA-3, and CO₂ as antiscalants, respectively. The flux profile and percent salt rejection achieved in Scheme 4 confirmed the higher efficiency of CO₂ utilization compared with other antifouling agents. This proficient role of CO₂ in fouling inhibition is further endorsed by the surface analysis of used membranes. The SEM, EDS, and XRD examination confirmed the higher suitability of CO₂ utilization in controlling scale deposition compared with other antiscalants. The cost estimation also supported the CO₂ utilization for environmental friendly and safe operation. Full article

Integral membrane proteins (IMPs) fulfill important physiological functions by providing cell–environment, cell–cell and virus–host communication; nutrients intake; export of toxic compounds out of cells; and more. However, some IMPs have obliterated functions due to polypeptide mutations, modifications in membrane properties and/or other environmental factors—resulting in damaged binding to ligands and the adoption of non-physiological conformations that prevent the protein from returning to its physiological state. Thus, elucidating IMPs’ mechanisms of function and malfunction at the molecular level is important for enhancing our understanding of cell and organism physiology. This understanding also helps pharmaceutical developments for restoring or inhibiting protein activity. To this end, in vitro studies provide invaluable information about IMPs’ structure and the relation between structural dynamics and function. Typically, these studies are conducted on transferred from native membranes to membrane-mimicking nano-platforms (membrane mimetics) purified IMPs. Here, we review the most widely used membrane mimetics in structural and functional studies of IMPs. These membrane mimetics are detergents, liposomes, bicelles, nanodiscs/Lipodisqs, amphipols, and lipidic cubic phases. We also discuss the protocols for IMPs reconstitution in membrane mimetics as well as the applicability of these membrane mimetic-IMP complexes in studies via a variety of biochemical, biophysical, and structural biology techniques. Full article

This review paper systematically evaluates current progress on the development and performance of photocatalytic nanofiber membranes often used in the removal of micropollutants from water systems. It is demonstrated that nanofiber membranes serve as excellent support materials for photocatalytic nanoparticles, leading to nanofiber membranes with enhanced optical properties, as well as improved recovery, recyclability, and reusability. The tremendous performance of photocatalytic membranes is attributed to the photogenerated reactive oxygen species such as hydroxyl radicals, singlet oxygen, and superoxide anion radicals introduced by catalytic nanoparticles such as TiO₂ and ZnO upon light irradiation. Hydroxyl radicals are the most reactive species responsible for most of the photodegradation processes of these unwanted pollutants. The review also demonstrates that self-cleaning and antimicrobial nanofiber membranes are useful in the removal of microbial species in water. These unique materials are also applicable in other fields such as wound dressing since the membrane allows for oxygen flow in wounds to heal while antimicrobial agents protect wounds against infections. It is demonstrated that antimicrobial activities against bacteria and photocatalytic degradation of micropollutants significantly reduce membrane fouling. Therefore, the review demonstrates that electrospun photocatalytic nanofiber membranes with antimicrobial activity form efficient cost-effective multifunctional composite materials for the removal of unwanted species in water and for use in various other applications such as filtration, adsorption and electrocatalysis. Full article

Membrane separation is a compelling technology for hydrogen separation. Among the different types of membranes used to date, the mixed-matrix membranes (MMMs) are one of the most widely used approaches for enhancing separation performances and surpassing the Robeson upper bound limits for polymeric membranes. In this review, we focus on the recent progress in MMMs for hydrogen separation. The discussion first starts with a background introduction of the current hydrogen generation technologies, followed by a comparison between the membrane technology and other hydrogen purification technologies. Thereafter, state-of-the-art MMMs, comprising emerging filler materials that include zeolites, metal-organic frameworks, covalent organic frameworks, and graphene-based materials, are highlighted. The binary filler strategy, which uses two filler materials to create synergistic enhancements in MMMs, is also described. A critical evaluation on the performances of the MMMs is then considered in context, before we conclude with our perspectives on how MMMs for hydrogen separation can advance moving forward. Full article

The unique functions of nanofibers (NFs) are based on their nanoscale cross-section, high specific surface area, and high molecular orientation, and/or their confined polymer chains inside the fibers. The introduction of ion-exchange (IEX) groups on the surface and/or inside the NFs provides de novo ion-exchangers. In particular, the combination of large surface areas and ionizable groups in the IEX-NFs improves their performance through indices such as extremely rapid ion-exchange kinetics and high ion-exchange capacities. In reality, the membranes based on ion-exchange NFs exhibit superior properties such as high catalytic efficiency, high ion-exchange and adsorption capacities, and high ionic conductivities. The present review highlights the fundamental aspects of IEX-NFs (i.e., their unique size-dependent properties), scalable production methods, and the recent advancements in their applications in catalysis, separation/adsorption processes, and fuel cells, as well as the future perspectives and endeavors of NF-based IEMs. Full article

Due to the high affinity of ceria (CeO₂) towards carbon dioxide (CO₂) and the high thermal and mechanical properties of cellulose triacetate (CTA) polymer, mixed-matrix CTA-CeO₂ membranes were fabricated. A facile solution-casting method was used for the fabrication process. CeO₂ nanoparticles at concentrations of 0.32, 0.64 and 0.9 wt.% were incorporated into the CTA matrix. The physico-chemical properties of the membranes were evaluated by SEM-EDS, XRD, FTIR, TGA, DSC and strain-stress analysis. Gas sorption and permeation affinity were evaluated using different single gases. The CTA-CeO₂ (0.64) membrane matrix showed a high affinity towards CO₂ sorption. Almost complete saturation of CeO₂ nanoparticles with CO₂ was observed, even at low pressure. Embedding CeO₂ nanoparticles led to increased gas permeability compared to pristine CTA. The highest gas permeabilities were achieved with 0.64 wt.%, with a threefold increase in CO₂ permeability as compared to pristine CTA membranes. Unwanted aggregation of the filler nanoparticles was observed at a 0.9 wt.% concentration of CeO₂ and was reflected in decreased gas permeability compared to lower filler loadings with homogenous filler distributions. The determined gas selectivity was in the order CO₂/CH₄ > CO₂/N₂ > O₂/N₂ > H₂/CO₂ and suggests the potential of CTA-CeO₂ membranes for CO₂ separation in flue/biogas applications. Full article

The reverse electrodialysis (RED) stack-harnessing salinity gradient power mainly consists of ion exchange membranes (IEMs). Among the various types of IEMs used in RED stacks, pore-filling ion exchange membranes (PIEMs) have been considered promising IEMs to improve the power density of RED stacks. The compositions of PIEMs affect the electrical resistance and permselectivity of PIEMs; however, their effect on the performance of large RED stacks have not yet been considered. In this study, PIEMs of various compositions with respect to the RED stack were adopted to evaluate the performance of the RED stack according to stack size (electrode area: 5 × 5 cm² vs. 15 × 15 cm²). By increasing the stack size, the gross power per membrane area decreased despite the increase in gross power on a single RED stack. The electrical resistance of the PIEMs was the most important factor for enhancing the power production of the RED stack. Moreover, power production was less sensitive to permselectivities over 90%. By increasing the RED stack size, the contributions of non-ohmic resistances were significantly increased. Thus, we determined that reducing the salinity gradients across PIEMs by ion transport increased the non-ohmic resistance of large RED stacks. These results will aid in designing pilot-scale RED stacks. Full article

The mammalian SLC7 family comprises the L-amino acid transporters (LATs) and the cationic amino acid transporters (CATs). The relevance of these transporters is highlighted by their involvement in several human pathologies, including inherited rare diseases and acquired diseases, such as cancer. In the last four years, several crystal or cryo-EM structures of LATs and CATs have been solved. These structures have started to fill our knowledge gap that previously was based on the structural biology of remote homologs of the amino acid–polyamine–organocation (APC) transporters. This review recovers this structural and functional information to start generating the molecular bases of the transport cycle of LATs. Special attention is given to the known transporter conformations within the transport cycle and the molecular bases for substrate interaction and translocation, including the asymmetric interaction of substrates at both sides of the plasma membrane. Full article

Environmental crisis and water contamination have led to worldwide exploration for advanced technologies for wastewater treatment, and one of them is photocatalytic degradation. A one-dimensional hollow nanofiber with enhanced photocatalytic properties is considered a promising material to be applied in the field. Therefore, we synthesized titanium dioxide hollow nanofibers (THNF) with extended surface area, light-harvesting properties and an anatase–rutile heterojunction via a template synthesis method and followed by a calcination process. The effect of calcination temperature on the formation and properties of THNF were determined and the possible mechanism of THNF formation was proposed. THNF nanofibers produced at 600 °C consisted of a mixture of 24.2% anatase and 75.8% rutile, with a specific surface area of 81.2776 m²/g. The hollow nanofibers also outperformed the other catalysts in terms of photocatalytic degradation of MB dye, at 85.5%. The optimum catalyst loading, dye concentration, pH, and H₂O₂ concentration were determined at 0.75 g/L, 10 ppm, pH 11, and 10 mM, respectively. The highest degradation of methylene blue dye achieved was 95.2% after 4 h of UV irradiation. Full article

The objective of this work was to evaluate obtaining LiOH directly from brines with high LiCl concentrations using bipolar membrane electrodialysis by the analysis of Li⁺ ion transport phenomena. For this purpose, Neosepta BP and Fumasep FBM bipolar membranes were characterized by linear sweep voltammetry, and the Li⁺ transport number in cation-exchange membranes was determined. In addition, a laboratory-scale reactor was designed, constructed, and tested to develop experimental LiOH production tests. The selected LiCl concentration range, based on productive process concentrations for Salar de Atacama (Chile), was between 14 and 34 wt%. Concentration and current density effects on LiOH production, current efficiency, and specific electricity consumption were evaluated. The highest current efficiency obtained was 0.77 at initial concentrations of LiOH 0.5 wt% and LiCl 14 wt%. On the other hand, a concentrated LiOH solution (between 3.34 wt% and 4.35 wt%, with a solution purity between 96.0% and 95.4%, respectively) was obtained. The results of this work show the feasibility of LiOH production from concentrated brines by means of bipolar membrane electrodialysis, bringing the implementation of this technology closer to LiOH production on a larger scale. Moreover, being an electrochemical process, this could be driven by Solar PV, taking advantage of the high solar radiation conditions in the Atacama Desert in Chile. Full article

A core component of energy storage systems like vanadium redox flow batteries (VRFB) is the polymer electrolyte membrane (PEM). In this work, the frequently used perfluorosulfonic-acid (PFSA) membrane Nafion™ 117 and a novel poly (vinylidene difluoride) (PVDF)-based membrane are investigated. A well-known problem in VRFBs is the vanadium permeation through the membrane. The consequence of this so-called vanadium crossover is a severe loss of capacity. For a better understanding of vanadium transport in membranes, the uptake of vanadium ions from electrolytes containing V_dimer(IV–V) and for comparison also V(II), V(III), V(IV), and V(V) by both membranes was studied. UV/VIS spectroscopy, X-ray absorption near edge structure spectroscopy (XANES), total reflection X-ray fluorescence spectroscopy (TXRF), inductively coupled plasma optical emission spectrometry (ICP-OES), and micro X-ray fluorescence spectroscopy (microXRF) were used to determine the vanadium concentrations and the species inside the membrane. The results strongly support that V_dimer(IV–V), a dimer formed from V(IV) and V(V), enters the nanoscopic water-body of Nafion™ 117 as such. This is interesting, because as of now, only the individual ions V(IV) and V(V) were considered to be transported through the membrane. Additionally, it was found that the V_dimer(IV–V) dimer partly dissociates to the individual ions in the novel PVDF-based membrane. The V_dimer(IV–V) dimer concentration in Nafion™ was determined and compared to those of the other species. After three days of equilibration time, the concentration of the dimer is the lowest compared to the monomeric vanadium species. The concentration of vanadium in terms of the relative uptake λ = n(V)/n(SO₃) are as follows: V(II) [λ = 0.155] > V(III) [λ = 0.137] > V(IV) [λ = 0.124] > V(V) [λ = 0.053] > V_dimer(IV–V) [λ = 0.039]. The results show that the V_dimer(IV–V) dimer needs to be considered in addition to the other monomeric species to properly describe the transport of vanadium through Nafion™ in VRFBs. Full article

Recently, the demand for the recovery of valuable solutes from organic solvents/water mixtures has increased in various fields. Furthermore, due to the abundance of heat-sensitive valuable solutes, the demand for non-heated concentration technologies has increased. In this study, the direct contact membrane distillation (DCMD) using hydrophobic polyvinylidene difluoride (PVDF) hollow fiber membranes was investigated to confirm the possibility of recovering valuable solutes from organic solvents/water mixtures as a non-heated process. The DCMD with 1000 ppm NaCl aqueous solution achieved 0.8 kg/m²·h of vapor flux and >99.9% of NaCl retention, even at feed and coolant temperatures of 25 and 10 °C, respectively. Furthermore, when DCMD was conducted under various conditions, including feed temperatures of 25, 35 and 45 °C, and organic solvent concentration of 15, 30 and 50 wt%, using ethanol/water and acetonitrile/water mixtures containing 1000 ppm NaCl. A surfactant was also used as a valuable solute, in addition to NaCl. As a result, it was found that the total vapor flux increased with increasing temperature and concentration of organic solvents, as the partial vapor pressure of the organic solvents increased. Additionally, no solute leaked under any condition, even when the surfactant was used as a valuable solute. Full article

A promising solution for membrane fouling reduction in membrane bioreactors (MBRs) could be the adjustment of operating parameters of the MBR, such as hydraulic retention time (HRT), food/microorganisms (F/M) loading and dissolved oxygen (DO) concentration, aiming to modify the sludge morphology to the direction of improvement of the membrane filtration. In this work, these parameters were investigated in a step-aerating pilot MBR that treated municipal wastewater, in order to control the filamentous population. When F/M loading in the first aeration tank (AT₁) was ≤0.65 ± 0.2 g COD/g MLSS/d at 20 ± 3 °C, DO = 2.5 ± 0.1 mg/L and HRT = 1.6 h, the filamentous bacteria were controlled effectively at a moderate filament index of 1.5–3. The moderate population of filamentous bacteria improved the membrane performance, leading to low transmembrane pressure (TMP) at values ≤ 2 kPa for a great period, while at the control MBR the TMP gradually increased reaching 14 kPa. Soluble microbial products (SMP), were also maintained at low concentrations, contributing additionally to the reduction of ΤΜP. Finally, the step-aerating MBR process and the selected imposed operating conditions of HRT, F/M and DO improved the MBR performance in terms of fouling control, facilitating its future wider application. Full article

The objective of this study is to clarify the pore structure of ECMO membranes by using our approach and theoretically validate the risk of SARS-CoV-2 permeation. There has not been any direct evidence for SARS-CoV-2 leakage through the membrane in ECMO support for critically ill COVID-19 patients. The precise pore structure of recent membranes was elucidated by direct microscopic observation for the first time. The three types of membranes, polypropylene, polypropylene coated with thin silicone layer, and polymethylpentene (PMP), have unique pore structures, and the pore structures on the inner and outer surfaces of the membranes are completely different anisotropic structures. From these data, the partition coefficients and intramembrane diffusion coefficients of SARS-CoV-2 were quantified using the membrane transport model. Therefore, SARS-CoV-2 may permeate the membrane wall with the plasma filtration flow or wet lung. The risk of SARS-CoV-2 permeation is completely different due to each anisotropic pore structure. We theoretically demonstrate that SARS-CoV-2 is highly likely to permeate the membrane transporting from the patient’s blood to the gas side, and may diffuse from the gas side outlet port of ECMO leading to the extra-circulatory spread of the SARS-CoV-2 (ECMO infection). Development of a new generation of nanoscale membrane confirmation is proposed for next-generation extracorporeal membrane oxygenator and system with long-term durability is envisaged. Full article

The formation of porous structures from polymer solutions at the surface in contact with various solid surfaces via a thermally-induced phase separation (TIPS) process is investigated. The pore formation process at the bulk and the surface of the poly(methyl methacrylate)/cyclohexanol solution is simulated with a model based on the phase field method. When the compatibilities between the polymer-rich phase formed by the phase separation and the solid surface are high or low, surface porosity decreases. In contrast, for the solid surface having similar compatibilities with the polymer and solvent, high surface porosity is achieved. This indicates that the compatibility between the solid surface and polymer solution is important, and that optimal compatibility results in high surface porosity. The knowledge obtained in this work is useful to design the coagulation bath component in the membrane preparation process by TIPS for achieving high surface porosity. Full article

Various pollutants of different sizes are directly (e.g., water-borne diseases) and indirectly (e.g., accumulation via trophic transfer) threatening our water health and safety. To cope with this matter, multifaceted approaches are required for advanced wastewater treatment more efficiently. Wastewater treatment using mixed matrix membranes (MMMs) could provide an excellent alternative since it could play two roles in pollutant removal by covering adsorption and size exclusion of water contaminants simultaneously. This paper provides an overview of the research progresses and trends on the emerging materials used to prepare MMMs for pollutant removal from water in the recent five years. The transition of the research trend was investigated, and the most preferred materials to prepare MMMs were weighed up based on the research trend. Various application examples where each emerging material was used have been introduced along with specific mechanisms underlying how the better performance was realized. Lastly, the perspective section addresses how to further improve the removal efficiency of pollutants in an aqueous phase, where we could find a niche to spot new materials to develop environmentally friendly MMMs, and where we could further apply MMMs. Full article

Three different zeolite nanocrystals (SAPO-34, PS-MFI and ETS-10) were incorporated into the polymer matrix (Matrimid^® 5218) as polymer precursors, with the aim of fabricating mixed-matrix carbon molecular sieve membranes (CMSMs). These membranes are investigated for their potential for air separation process. Based on our gas permeation results, incorporating porous materials is feasible to improve O₂ permeability, owing to the creation of additional porosities in the resulting mixed-matrix CMSMs. Owing to this, the performance of the CMSM with 30 wt% PS-MFI loading is able to surpass the upper bound limit. This study demonstrates the feasibility of zeolite nanocrystals in improving O₂/N₂ separation performance in CMSMs. Full article

In this study, silver/silver oxide nanoparticles (Ag/Ag₂O NPs) were successfully biosynthesized using Phoenix dactylifera L. aqueous leaves extract. The effect of different plant extract/precursor contractions (volume ratio, v/v%) on Ag/Ag₂O NP formation, their optical properties, and photocatalytic activity towards azo dye degradation, i.e., Congo red (CR) and methylene blue (MB), were investigated. X-ray diffraction confirmed the crystalline nature of Ag/Ag₂O NPs with a crystallite size range from 28 to 39 nm. Scanning electron microscope images showed that the Ag/Ag₂O NPs have an oval and spherical shape. UV–vis spectroscopy showed that Ag/Ag₂O NPs have a direct bandgap of 2.07–2.86 eV and an indirect bandgap of 1.60–1.76 eV. Fourier transform infrared analysis suggests that the synthesized Ag/Ag₂O NPs might be stabilized through the interactions of -OH and C=O groups in the carbohydrates, flavonoids, tannins, and phenolic acids present in Phoenix dactylifera L. Interestingly, the prepared Ag/Ag₂O NPs showed high catalytic degradation activity for CR dye. The photocatalytic degradation of the azo dye was monitored spectrophotometrically in a wavelength range of 250–900 nm, and a high decolorization efficiency (84.50%) was obtained after 50 min of reaction. As a result, the use of Phoenix dactylifera L. aqueous leaves extract offers a cost-effective and eco-friendly method. Full article

Membrane proteins work within asymmetric bilayers of lipid molecules that are critical for their biological structures, dynamics and interactions. These properties are lost when detergents dislodge lipids, ligands and subunits, but are maintained in native nanodiscs formed using styrene maleic acid (SMA) and diisobutylene maleic acid (DIBMA) copolymers. These amphipathic polymers allow extraction of multicomponent complexes of post-translationally modified membrane-bound proteins directly from organ homogenates or membranes from diverse types of cells and organelles. Here, we review the structures and mechanisms of transmembrane targets and their interactions with lipids including phosphoinositides (PIs), as resolved using nanodisc systems and methods including cryo-electron microscopy (cryo-EM) and X-ray diffraction (XRD). We focus on therapeutic targets including several G protein-coupled receptors (GPCRs), as well as ion channels and transporters that are driving the development of next-generation native nanodiscs. The design of new synthetic polymers and complementary biophysical tools bodes well for the future of drug discovery and structural biology of native membrane:protein assemblies (memteins). Full article