Modern Diagnosis and Antimicrobial Stewardship in the Management of Helicobacter pylori Infection

Dear Colleagues,

Helicobacter pylori (H. pylori) is the major pathogen of chronic active gastritis, peptic ulcer, and gastric cancer. In 1994, the World Health Organization declared H. pylori to be a definite carcinogen for gastric cancer. More than half of the world’s population are infected with H. pylori. In H. pylori–infected stomachs, gastric atrophy and intestinal metaplasia are linked to gastric cancer development. H. pylori treatment is strongly recommended for preventing primary gastric cancer in recent guidelines. Endoscopic biopsy-based tests such as the rapid urease test, histological examination, and culture have been widely used to diagnose H. pylori infection. Recently, molecular tests and non-invasive methods including next-generation sequencing were developed to diagnose the infection status and identify H. pylori resistance against antimicrobial agents. However, the rate of H. pylori antimicrobial resistance has increased worldwide. In this era of increasing antibiotic resistance, obtaining successful H. pylori eradication is challenging. In the future, antimicrobial stewardship plays a crucial role in H. pylori treatment, decreasing the overuse and misuse of antibiotics. The forthcoming Special Issue focuses on modern approach to the diagnosis and treatment of H. pylori infection.

Prof. Dr. Jun-Hyung Cho
Guest Editor

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• Helicobacter pylori
• diagnosis
• eradication
• antibiotics resistance
• clarithromycin
• metronidazole
• molecular test
• next-generation sequencing