Impact of Fecal Microbiota Transplantation on Human Health

Dear Colleagues,

Fecal microbiota transplantation (FMT) consists in the infusion of a feces suspension obtained from a healthy donor into the intestinal tract of a recipient patient. The principle of FMT is the reconstitution of a eubiotic state in an altered intestinal bacterial community or providing potentially protective bacteria against local and systemic pathologies.

Therefore, the restoration of a eubiotic state is not only indicated in intestinal infectious diseases but also in noninfectious diseases. In fact, a normal bacterial community provides protection against an inflammatory status that may have potential systemic effects. Conversely, overexpressed bacterial communities can stimulate inflammatory processes, triggering neurodegenerative disorders such as Parkinson’s disease, amyolateral sclerosis, multiple sclerosis, and autism.

As is evident in the literature, the potential therapeutic options are numerous when considering the capability of FMT to modulate an eventual dysbiotic status, as described in intestinal bowel diseases, cardiovascular diseases, immunity disorders, hepatic encephalopathy, psychiatric conditions, and others.

The aim of this Topic Collection is to provide current and thoughtful scientific evidence of the clinical impact of FMT on human health.

Thus, we especially welcome interventional and observational studies aiming to improve the knowledge of FMT’s effects on systemic health and of its use for the treatment of local and systemic diseases. Review studies, including those that use conceptual frameworks for any of the aforementioned topics, will also be welcomed.

Dr. Luca Masucci
Dr. Gianluca Quaranta
Collection Editors

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