Peptidomimetics: Synthetic Tools for Drug Discovery and Development
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 251
Special Issue Editor
Interests: retroviruses; HIV-1; protein–protein interactions; Brd4-mediated cancers; drug discovery; small-molecule inhibitors; antivirals
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Peptidomimetic-based drug discovery is a rapidly expanding and powerful avenue for the discovery of novel therapeutics for a wide range of malignancies. Through the use of small protein-like chains that mimic the essential pharmacophores of naturally occurring protein–protein and protein–peptide interactions, drugs can be developed to exploit these key interfaces. Peptidomimetics have been utilized in targeted chemotherapy, immunosuppression, antiviral therapy, and the modulation of receptor–ligand interactions among many other biological interventions in humans and animals. Improvements to naturally occurring protein ligands can be derived from rational drug design and/or molecular modeling to combat issues encountered with natural peptides, including limited bioavailability and stability. The goal of this Special Issue is to bring together the expertise and knowledge related to utilizing and adapting peptidomimetic-based approaches for drug discovery and development. We anticipate submissions covering a variety of topics from molecular modeling, drug design, synthetic chemistry, biochemical and biophysical interaction studies, and cell-based inhibition or viability approaches utilizing peptidomimetic compounds.
Dr. Ross Larue
Guest Editor
Manuscript Submission Information
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Keywords
- peptidomimetics
- drug discovery
- therapeutics
- protein ligands
- peptide mimics
- small molecule drug design
- drug screening
- targeting protein interfaces
