The Development of New Drug Delivery Systems to Treat Tumors Affecting the Central Nervous System

Dear Colleagues,

Tumors affecting the central nervous system (CNS, brain, and spinal cord) present an incidence of 321,731 new cases, being responsible for 248,500 deaths annually. Moreover, these tumors are the most common solid neoplasms and the leading cause of death from cancer in children, accounting for approximately 20% of childhood cancers. The advances observed in recent years, both in diagnostic and therapeutic aspects, improved the clinical outcomes; however, they are still insufficient, and some CNS tumors such as glioblastoma are still considered clinically unmet due to the lack of effective therapeutic options. The presence of the blood–brain barrier limits the doses of chemotherapy that can reach the tumors, leading to unsatisfactory therapeutic activity. For this reason, surgical resection is still a common therapeutic approach to treat CNS tumors. However, due to the complex nature and biological importance of the CNS, some tumors are non-operable, and/or total resection is not possible without affecting the normal and vital functions. This emphasizes the need for new and improved therapeutic approaches for the management and treatment of CNS tumors. This Special Issue intends to explore the most recent drug delivery systems developed to treat tumors affecting the central nervous system that could bring new hope for treatment.

Dr. Diana Rafael
Dr. Fernanda Andrade
Guest Editors

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