Nanotechnology-Enabled Strategies to Enhance Topical Bioavailability, 3rd Edition

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 1018

Special Issue Editors


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Guest Editor
Department of Pharmaceutical Technology, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
Interests: topical bioavailability; solid-state preformulation; nanoparticles
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Department of Pharmaceutical Physics, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy Timisoara, 2nd EftimieMurgu Sq., 300041 Timişoara, Romania
2. Research Center for Pharmaco-Toxicological Evaluations, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania
Interests: nanodelivery systems; stimuli-controlled release; bioavailability; in vitro assessments using cell monolayer and 3D human reconstructed microtissues
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The design and development of new topical formulations are trending topics, especially in the biomedical field, as they can be conceived to not only address protective and cosmetic needs, but also target therapeutic outcomes.

Because one of the main functions of human skin is protection—the skin acts as a barrier to the penetration of various external factors—the penetration of active substances through the skin is impaired, thus limiting their therapeutic potential. To overcome this, innovative strategies are required to increase skin permeability by means of penetration promoters.

In this regard, modern nanotechnology-based formulations are under development, such as derived liposomal formulations (transferosomes, ethosomes, cubosomes, nanostructured lipid carriers or other lipid-based nanocarriers), nanogels, nanoemulsions, cyclodextrin-based formulations and other modern approaches.

For the current Special Issue, original research and review articles addressing recent advances in nanopharmaceutical formulations with enhanced topical bioavailability and complex biological in vitro and/or in vivo profiles are welcome for submission.

Dr. Lenuţa Şuta
Dr. Claudia Geanina Watz
Guest Editors

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Keywords

  • nanotechnology-based formulations
  • drug-in nanocarriers
  • cyclodextrin-in nanocarriers
  • polymer-based nanocarriers
  • topical drug-delivery systems
  • bioavailability enhancement
  • drug release in vitro and in vivo
  • skin models
  • biological assessments

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Published Papers (1 paper)

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Review

31 pages, 2088 KiB  
Review
SLNs and NLCs for Skin Applications: Enhancing the Bioavailability of Natural Bioactives
by Diana Antonia Safta, Cătălina Bogdan and Mirela-Liliana Moldovan
Pharmaceutics 2024, 16(10), 1270; https://doi.org/10.3390/pharmaceutics16101270 - 28 Sep 2024
Viewed by 580
Abstract
Natural bioactives are mixtures of compounds extracted from plants with physicochemical properties that are usually not favorable for penetrating the skin’s complex barrier. Nanoparticles have important advantages both in dermatology and cosmetology: improved solubility and stability of encapsulated phytocompounds, controlled and sustained skin [...] Read more.
Natural bioactives are mixtures of compounds extracted from plants with physicochemical properties that are usually not favorable for penetrating the skin’s complex barrier. Nanoparticles have important advantages both in dermatology and cosmetology: improved solubility and stability of encapsulated phytocompounds, controlled and sustained skin delivery, and enhanced skin permeation, leading to an improved bioavailability. This review focuses on two generations of lipid-based nanoparticles: solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs). An extensive overview on the recent studies on SLNs and NLCs entrapping essential oils, oils, herbal extracts, and phytocompounds for topical applications is presented, emphasizing their composition, physicochemical characterization, efficacy, and methodologies used to evaluate them. This review also summarizes topical systems containing natural bioactives incorporated into SLNs and NLCs, commercially available products and registered patents in the field. SLNs and NLCs turn out to be effective nanocarriers for skin applications, offering significantly improved encapsulation efficiency, stability, and bioactives delivery. However, their full potential is underexplored. Future applications should study the encapsulation potential of new natural bioactives and show more specialized solutions that address specific requirements; an improved product performance and a pleasant sensory profile could lead to increased customer compliance with the product use. Full article
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