Cocrystallization for Drug Delivery
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".
Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 218
Special Issue Editor
Interests: solid-state characterization; drug-excipient compatibility; solid dispersions; co-crystals; dissolution studies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Pharmaceutical cocrystals are currently a hot topic in the pharmaceutical industry due to their ability to improve the solubility, stability, in vitro dissolution rate, and bioavailability of poorly soluble drugs. This is especially interesting for BCS class II drugs. Additionally, multidrug cocrystals have been studied to improve the potential applications of cocrystals and increase the therapeutic efficacy of combined drugs. Several strategies have been reported for preparing cocrystals, and different methods are then carried out for complete solid-state characterization. An important step is to understand the behavior of cocrystals as supersaturating drug delivery systems, studying drug supersaturation and precipitation processes and the influence of precipitation inhibitors. This way, cocrystals can be considered promising active pharmaceutical ingredients for better formulations with improved therapeutic efficacy.
This Special Issue aims to present recent advances in cocrystallization for drug delivery, covering all aspects from cocrystal synthesis to in vivo studies. Both reviews and research manuscripts are welcome to be submitted, thus contributing to this exciting field of investigation.
Prof. Dr. Paulo Renato De Oliveira
Guest Editor
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Keywords
- cocrystals
- multidrug cocrystals
- cocrystallization
- solid-state characterization
- pharmaceutical forms
- scale-up technologies
- dissolution
- supersaturation
- precipitation inhibitors
- stability
