Plant Extracts with Antihyperglycemic and Antidiabetic Effects

Dear Colleagues,

Diabetes mellitus is a chronic metabolic disease marked by high blood sugar levels due to abnormal insulin synthesis or action. Currently, the global prevalence of diabetes is 9.3%; this figure will reach 10.2% by 2030 and 10.9% by 2045. Globally, about 50% of diabetes cases are undiagnosed, owing to the unawareness of symptoms, the majority of which come from low- and middle-income countries. Furthermore, poor blood D-glucose control in diabetic patients leads to permanent hyperglycemia. In diabetic patients, postprandial hyperglycemia is involved in plasmatic and cellular proteins which take part in the development of diabetes complications. In this regard, diabetes mellitus management requires accurate postprandial glycemic control through decreasing glucose absorption. Different treatments are currently used to manage diabetes, such as insulin, dietetic therapies, and pharmacotherapy. Since antiquity, people have used plants to perfume themselves, clothe themselves, feed themselves, and heal themselves. Indeed, thanks to the availability, low cost, and therapeutic effectiveness of these natural products, the population rate that uses medicinal plants to treat disease spills is high and estimated as 80%, according to a WHO report. Many medicinal plants are traditionally used in the management of diabetes throughout the world. Marles and Farnsworth estimated that more than 1000 plant species are being used against DM. The efficacy and safety of some plants have been sufficiently validated by clinical use over thousands of years. This Special Issue of Plants will aim to study the antihyperglycemic and antidiabetic effects of medicinal plant extracts and shed light on the possible mechanisms of these effects.

Prof. Dr. Mohamed Bouhrim
Guest Editor

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• medicinal plant
• natural products
• phenolic compounds
• in silico
• in vitro
• ex vivo
• in situ
• in vivo
• antihyperglycemic
• diabetes