Applications of Chromatography in Pharmaceutical Analysis and Forensic Toxicology

Dear Colleagues,

We are pleased to invite you to publish in this Special Issue focused on the application of chromatography techniques in pharmaceutical and forensic toxicological analysis. In this field, chromatography is one of the most used biophysical techniques that enables the separation, identification, and purification of xenobiotics and their metabolites for qualitative and quantitative analysis. In particular, High-Performance Liquid Chromatography (HPLC) and Gas Chromatography (GC) have become the most widely used approaches for pharmaceutical and toxicological purposes, most often using combined techniques such as mass spectrometry (LC-MS, LC-MS/MS, GC-MS, GC-MS/MS) due to their high sensitivity and selectivity. Purification techniques as sample pretreatment and extraction, preceding chromatography, are pivotal to provide an extract ideally free from interferences and therefore suitable for selective chromatographic analysis.

This Special Issue aims to provide an overview of articles relating to the isolation, identification, quantitation, and interpretation of pharmaceutical or potentially toxic substances and their biotransformation products in specimens of multiple origins through the applications of chromatography techniques.

The methods should be applicable to the following fields: pharmaceutical, therapeutic drug monitoring, drug metabolism and pharmacokinetics, drugs-of-abuse testing, clinical and forensic toxicology. This Special Issue focuses on different procedures, e.g., method development and validation, compounds separation, physicochemical properties and quality attributes.

Original Articles, Case Reports, Technical Notes, Reviews or Letters to the Editor covering a wide range of chromatographic procedures are welcome.

Topics include, but are not limited to, applications in the following areas:

• Forensic toxicology;
• Pharmaceutical analysis;
• Drug discovery;
• New psychoactive drugs;
• Optimization of the chromatographic conditions.

Dr. Sara Casati
Dr. Marica Orioli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• liquid chromatography
• drug analysis
• forensic analysis
• toxicological analysis
• sample preparation
• method validation
• method developement
• biological matrices
• pharmaceutical preparation