Recent Progress in Multidrug-Resistant Acinetobacter baumannii

Dear Colleagues,

According to the WHO, antibiotic resistance has become one of the major global threats to mankind due to the emergence of new resistance mechanisms by bacteria that enable them to overcome both natural and chemical elimination systems, such as the immune system and antibiotics. Since the 1940s, medical experts have warned about the aimless use of antibiotics, but the outlay on antibiotics has continued to increase.

An opportunistic pathogen called Acinetobacter baumannii is known for its high mortality rate, associated with hospital-acquired infections. In 2017, the WHO global priority list of antibiotic-resistant bacteria listed A. baumannii as a critical priority pathogen; scientists around the world will be guided on what must be accomplished so that new treatments can be found in an urgent for the treatment of antibiotic-resistant A. baumannii. The prevalence of A. baumannii infections and outbreaks emphasizes the direct need for the use of effective therapeutic agents for treating such infections. Due to the emergence of multidrug-resistant strains, existing antimicrobials like carbapenems, tigecycline, and colistin cannot provide adequate effectiveness. Alternative and novel therapeutic remedies are therefore needed. It is important to have knowledge of recent discoveries regarding the virulence factors and the mechanisms of the antimicrobial resistance of A. baumannii.

Dr. Razique Anwer
Dr. Sunil Kumar
Guest Editors

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