Search Results (1,007)

This research evaluates Battery Energy Storage Systems (BESS) and Compressed Air Vessels (CAV) as complementary solutions for enhancing micro-grid resilience, flexibility, and sustainability. BESS units ranging from 5 to 400 kWh were modeled using a Nonlinear Autoregressive Neural Network with Exogenous Inputs (NARX) neural network, achieving high SOC prediction accuracy with R² > 0.98 and MSE as low as 0.13 kWh². Larger batteries (400–800 kWh) effectively reduced grid purchases and redistributed surplus energy, improving system efficiency. CAVs were tested in pumped-storage mode, achieving 33.9–57.1% efficiency under 0.5–2 bar and high head conditions, offering long-duration, low-degradation storage. Waterhammer-induced CAV storage demonstrated reliable pressure capture when Reynolds number ≤ 75,000 and Volume Fraction Ratio, VFR > 11%, with a prototype reaching 6142 kW and 170 kWh at 50% air volume. CAVs proved modular, scalable, and environmentally robust, suitable for both energy and water management. Hybrid systems combining BESS and CAVs offer strategic advantages in balancing renewable intermittency. Machine learning and hydraulic modeling support intelligent control and adaptive dispatch. Together, these technologies enable future-ready micro-grids aligned with sustainability and grid stability goals. Full article

To address the challenge of laser beam distortion induced by thermal effects in high-power slab laser amplifiers, a coupled thermal–mechanical–optical model for a face-pumped Yb:YAG multi-pass amplifier was developed. The thermal effects under different thermal management strategies were systematically investigated using the finite element method. Firstly, the temperature distribution, thermal stress, and deformation within the Yb:YAG crystal were analyzed and compared under both room-temperature (293 K) and cryogenic (150 K) cooling conditions using a microchannel cooling structure. The results demonstrate that under a pump power of 100 W and room-temperature cooling, the peak temperature of the gain medium reaches 363 K, with a peak thermal stress of 1.04 MPa and a maximum thermal deformation of 1.44 μm. In contrast, under cryogenic cooling at 150 K, the maximum temperature is reduced to 188 K, and both thermal stress and deformation exhibit a more uniform distribution within the pumped region. Subsequently, the thermal lensing of bonded and non-bonded Yb:YAG crystals was compared and analyzed by ray-tracing. It was found that under a pump power of 100 W, the thermal focal lengths of non-bonded Yb:YAG are 1112 mm and 2559 mm at cooling temperatures of 293 K and 150 K, respectively. For bonded crystals with a 3 mm undoped YAG thickness under identical pumping and cooling conditions, the corresponding thermal focal lengths measure 1508 mm and 3044 mm. When the undoped YAG thickness increases to 6 mm, the thermal focal lengths further extend to 1789 mm and 4206 mm, respectively. Full article

The elbow suction conduit plays a decisive role in determining inflow conditions, thereby influencing a pump’s efficiency and cavitation characteristics. The complex three-dimensional swirling and separating flow makes pinpointing the sources and mechanisms of energy dissipation challenging. This study aims to accurately diagnose the sources of hydraulic losses within the elbow suction conduit and conduct effective geometric optimization to enhance overall pump performance. Entropy production theory was integrated with three-dimensional Reynolds-averaged Navier-Stokes simulations to quantitatively analyze the irreversible energy dissipation in different parts of the conduit. Results reveal that energy dissipation is predominantly concentrated at the inlet section, wall surfaces, outer curvature of the bend, and the inner conical diffuser. Key geometric parameters were systematically optimized. Compared to the baseline design, the optimized configuration not only reduced entropy generation induced by wall shear and turbulent fluctuations but also improved the spatio-temporal uniformity of the outflow. Consequently, this translated directly into enhanced overall pump performance: the optimized design shows a 0.34% increase in efficiency and a 3.6% reduction in the inception cavitation coefficient at the rated condition, leading to lower energy consumption and enhanced operational reliability. The effectiveness of entropy production analysis for the hydraulic optimization of pumps was demonstrated. Full article

The Bell–Bloom magnetometer is promising for mobile applications, but its accuracy is limited by heading errors. A recently identified source of such error is a phase shift in the magnetic resonance, which arises from the superposition of two signals, i.e., the primary resonance from synchronous pumping and a secondary resonance, 90° out-of-phase, driven by the AC light shift of the pump laser. Through Bloch equation modeling and experiment, we uncover a counter-intuitive mechanism: although initiated by the AC light shift, the phase shift’s magnitude is determined solely by the pump light’s average power (DC component) and is independent of its AC modulation. This occurs because the amplitude ratio of the two resonances depends exclusively on the DC-power-induced atomic polarization. Based on this insight, we propose a novel DC compensation scheme by adding a continuous counter-polarized beam to cancel the net DC pumping. Theoretically, this simultaneously suppresses both the AC-light-shift-induced phase shift and the DC-light-shift-induced frequency shift. The scheme’s advantage is its simplified approach to polarization control, avoiding the need for high-speed polarization modulation or major hardware changes as the beams share the same optical path. This makes it highly suitable for demanding mobile applications like aerial magnetic surveying and wearable bio-magnetic sensing in unshielded environments. Full article

A coupled CFD-DEM model was adopted to investigate the floating ice accumulation mechanism and its disturbance to the flow field in the pump house of coastal nuclear power plants in cold regions. Based on numerical simulations, the motion, accumulation, and flow interaction characteristics of floating ice under various release positions and heights were analyzed. The results indicate that the release height significantly governs the accumulation morphology and hydraulic response. The release height critically determines ice accumulation patterns and hydraulic responses. For inlet scenarios, lower heights induce a dense, wedge-shaped accumulation at the coarse trash rack, increasing thickness by 57.69% and shifting the accumulation 38.16% inlet-ward compared to higher releases. Conversely, higher releases enhance dispersion, expanding disturbances to the central pump house and intensifying flow heterogeneity. In bottom release cases, lower heights form wall-adhering accumulations, while higher releases cause ice to rise into mid-upper layers, thereby markedly intensifying local vortices (peak intensity 79.68, approximately 300% higher). Spatial release locations induce 2.7–4.8-fold variations in flow disturbance intensity across monitoring points. These findings clarify the combined impact of the release height and location on the ice accumulation and flow field dynamics, offering critical insights for the anti-ice design and flow safety assessment of pump houses. Full article

Harmonic-assisted phase amplification was investigated in a 300-µm-thick Nd:GdVO₄ laser with coated end mirrors in the self-mixing interference scheme. The key event is the self-induced hybrid skew cosh Gaussian (abbreviated as skew ch-G)-type transverse mode oscillation in a thin-slice solid-state laser with wide-aperture laser-diode pumping. The present hybrid skew-chG mode was proved to be formed by the locking of nearly frequency-degenerate TEM₀₀ and annular fields. The resultant modal-interference-induced gain modulation at the beat frequency between the two modal fields, which is far above the relaxation oscillation frequency, increased the experimental self-mixing modulation bandwidth accordingly. Fifty-fold phase amplification was achieved in a strong optical feedback regime. Full article

With the growing global demand for renewable energy, the pump as turbine (PAT) exhibits significant potential in the micro-hydropower sector. To reveal its internal unsteady flow characteristics and energy loss mechanisms, this study analyzes the internal flow field of an ultra-low specific speed pump as turbine (USSPAT) by employing a combined approach of entropy generation theory and dynamic mode decomposition (DMD). The results indicate that the outlet pressure pulsation characteristics are highly dependent on the flow rate. Under low flow rate conditions, pulsations are dominated by low-frequency vortex bands induced by rotor-stator interaction (RSI), whereas at high flow rates, the blade passing frequency (BPF) becomes the absolute dominant frequency. Energy losses within the PAT are primarily composed of turbulent and wall dissipation, concentrated in the impeller and volute, particularly at the impeller inlet, outlet, and near the volute tongue. DMD reveals that the flow field is governed by a series of stable modes with near-zero growth rates, whose frequencies are the shaft frequency (25 Hz) and its harmonics (50 Hz, 75 Hz, 100 Hz). These low-frequency modes, driven by RSI, contain the majority of the fluctuation energy. Therefore, this study confirms that RSI between the impeller and the volute is the root cause of the dominant pressure pulsations and periodic energy losses. This provides crucial theoretical and data-driven guidance for the design optimization, efficient operation, and stability control of PAT. Full article

Background: Alpha-linolenic acid (ALA) is an essential fatty acid from the omega-3 family that plays an important role in skin homeostasis. It is known for its anti-inflammatory properties, which can contribute to wound healing. Neurotrophins, such as Brain-Derived Neurotrophic Factor (BDNF), may also play an important role in the skin, influencing nerve regeneration and pain modulation. Objectives: This article aims to explore the therapeutic effect of ALA on wound healing in streptozotocin-induced hyperglycemic mice, with an emphasis on the involvement of neurotrophins. Methods: We used keratinocyte cultures exposed or not to ALA and male C57BL6-J mice, which were randomly divided into four groups: non-hyperglycemic treated with vehicle; non-hyperglycemic treated with ALA; hyperglycemic treated with vehicle; and hyperglycemic treated with ALA. The treatment was administered continuously via a subcutaneous osmotic pump. Results: We found that controlled ALA administration potentiates the wound healing process in hyperglycemic mice by accelerating the inflammatory phase and promoting early granulation tissue formation (73.2% ± 0.7 vs. 92.2% ± 2.8 on day 7, n = 5; p < 0.05). This is supported by the balance between the expression of vimentin, CD31, and MMP-9. Furthermore, ALA modulates proteins linked to peripheral neurogenesis and gliogenesis, such as BDNF, NTRK2, SOX-10, CNTF, CTNFR, and STAT-3. It may also promote wound healing and nerve regeneration at the wound site in hyperglycemic animals. In non-hyperglycemic mice, ALA improves the quality of scars but does not accelerate the wound healing process, even with the positive modulation of certain genes relevant to skin healing. Conclusions: Alpha-linolenic acid improves skin wound healing and increases gene expression related to nerve regeneration in wounds of hyperglycemic mice. Full article

Background: Swallowed topical corticosteroids (STCs) are used as the first-line therapy for eosinophilic esophagitis (EoE) and have been extensively studied in randomized controlled trials (RCTs); however, the presentation and doses varied widely among the studies. Aim: The goal of this study was to compare the safety and effectiveness of the different STC-based options in EoE patients. Methods: We performed a literature search for RCTs, spanning a time period from database inception to July 2024, in order to compare the efficacy and safety of all STCs used to induce or maintain EoE remission each other and also with placebo or proton pump inhibitors (PPIs) in a network meta-analysis. Outcomes are expressed as pooled risk ratios (RRs) of failure and 95% confidence intervals (CIs), and we aimed to evaluate histological remission at <15–20 eosinophils per high-power field (eos/hpf), <5–6 eos/hpf, and <1 eos/hpf. The effect sizes for symptomatic improvement and the mean differences for endoscopic EREFS improvement with 95% CIs were also measured. Adverse events were evaluated using RRs, and these included oropharyngeal and esophageal candidiasis and adrenal suppression. Results: Twenty studies involving 1455 patients with active EoE reported on STC effectiveness to induce remission; three additional studies on 232 patients assessed the maintenance of remission. Budesonide 1 mg orodispersible tablets ranked highest in SUCRA in terms of all histological remission endpoints. Budesonide from inhalation devices was the only option superior to placebo in improving symptoms. Budesonide viscous suspension was the only option superior to placebo in improving endoscopy. No therapy was significantly associated with the risk of any adverse event. Significant inconsistencies and small study effects were detected in multiple comparisons. Conclusions: Budesonide orodispersible tablets were the best option for achieving EoE histological remission, but not symptomatic or endoscopic improvement. STC formulations were as safe as placebo or PPI. Full article

Inorganic nitrite contributes to the nitrosation of biomolecules and exerts antioxidant effects. The proton pump inhibitor omeprazole has pro-oxidant effects, inhibits the formation of nitroso species in the stomach, and abrogates the blood pressure-lowering effects of orally administered nitrite. Here, we examine whether a two-week treatment with nitrite leads to tissue nitrosation that scales with local thiol concentrations and whether oral nitrite treatment can prevent the pro-oxidant effects of omeprazole. Male Sprague–Dawley rats received daily doses of omeprazole 10 mg/kg i.p. (or vehicle) and sodium nitrite 15 mg/kg by gavage (or water) for 14 days. Animals were euthanized 6 h after the last nitrite dose, and blood and tissues (brain, heart, and liver) were collected for biochemical analyses. We found that nitrite treatment increased liver nitrite and total nitroso species (RxNO) concentrations approximately eight-fold (with minor increases in other organs), and omeprazole treatment attenuated these effects. Nitrite treatment selectively elevated non-protein thiol concentrations in the liver, but not in animals also receiving omeprazole. Tissue thiol elevation was associated with increased nitrosation of hepatic proteins, which was prevented by omeprazole. Nitrite upregulated mRNA expression of microsomal glutathione S-transferase-1 (Mgst1) and decreased superoxide and hydrogen peroxide production, especially in rats co-treated with omeprazole. While omeprazole increased liver xanthine oxidoreductase (XOR), nitrite treatment attenuated this effect. These results demonstrate that oral nitrite treatment robustly elevates nitrite and RxNO concentrations in the liver, and these effects are associated with increased hepatic glutathione production and an upregulation of Mgst1 expression, counteracting the pro-oxidant effects induced by omeprazole. Full article

This study investigates the steady-state behavior of a four-way opposed diaphragm pump. Simulations and experimental results confirm that peak stress locations align with observed damage sites. During the return stroke, diaphragm flipping induces tension at the flow-fixed interface edges, creating stress concentrations that contribute to fatigue and failure. Particle image velocimetry (PIV) shows that, under constant flow, increased voltage enhances umbrella valve opening, accelerates movement, broadens flow distribution, and disrupts symmetry. At 90°, valve-edge velocity exhibits sharp, high-amplitude oscillations and a narrow, elongated return region. Vortices near the valve port interfere with fluid motion, causing pressure fluctuations and potential sealing issues or increased opening resistance. Higher flow rates intensify vortex strength and shift their position, generating diaphragm pressure differentials that alter flow direction and velocity, reducing stability and inducing secondary vortices. Compared to a modified diaphragm, the standard type shows more complex vortex structures, greater flow instability, and dynamic response degradation under identical pressure and varying flow. These fragmented vortices further disrupt flow, affecting pump performance. The findings provide design insights for diaphragm pump optimization. Full article

Background/Objectives: Sepsis-induced cholestasis is caused by the release of inflammatory cytokines from lipopolysaccharide (LPS), a component of Gram-negative bacteria. No established therapy exists for this condition. We ascertained the anticholestatic potential of obeticholic acid (OCA), a potent FXR agonist, in a rat model of LPS-induced cholestasis. Methods: Male Wistar rats were randomized into Control, OCA (20 mg/kg/day, i.p., 6 days), LPS (total dose of 6.5 mg/kg, i.p., in the last 2 days, respectively), and OCA + LPS groups. Then, we assessed the serum cholestasis marker, alkaline phosphatase (ALP), and taurocholate-stimulated bile salt output. mRNA/protein levels of the main apical and sinusoidal uptake and efflux carriers were assessed by either or both RT-qPCR and Western blot. Bsep and Mrp2 localization was assessed by immunohistochemistry followed by confocal microscopy and image analysis. Inflammatory cytokines were measured in serum by ELISA. Results: OCA significantly attenuates inflammatory cytokine release and normalizes serum ALP in LPS-treated rats. OCA also increased the biliary output of the Bsep substrate, taurocholate, and partially improved total Bsep at both mRNA and protein levels. Furthermore, OCA fully normalizes Bsep in the canalicular plasma membrane fraction, suggesting improved membrane localization, a finding further confirmed by confocal microscopy. OCA sustained the beneficial downregulation of uptake transporters Ntcp and Oatp2 or the upregulation of the efflux pump Mrp3, both of which serve to minimize hepatocellular bile-salt accumulation. Conclusions: OCA prevents bile-salt accumulation in LPS-induced cholestasis by enhancing Bsep expression and localization, and by mitigating inflammation. This makes OCA a promising therapeutic candidate for sepsis-induced cholestasis. Full article

The Messara Basin, a critical agricultural region in Crete, Greece, faces escalating geohazards, particularly land subsidence driven by intensive groundwater abstraction. Historical radar interferometry (1992–2009) indicated subsidence up to 20 mm·yr⁻¹, while recent European Ground Motion Service data (2016–2021) show mean vertical velocities reaching −31.2 mm·yr⁻¹. This study provides the first integrated hydrogeological assessment for the Basin, based on systematic field surveys, borehole inventories, and four coordinated campaigns (2021–2023) that established a basin-wide monitoring network of 767 stations. The dataset supports delineation of recharge zones, identification of potentiometric depressions, and mapping of aquifer-stress areas. Results show strong seasonality and extensive cones of depression, with local heads declining to ~−50 m below sea level. Land-use change (1990–2018 CORINE data; 2000–2020 agricultural censuses) combined with updated geological mapping highlights the vulnerability of post-Alpine formations, especially Quaternary and Plio–Pleistocene deposits, to deformation. The combined evidence links pumping-induced head decline with spatially coherent subsidence, delineates hotspots of aquifer stress, and identifies zones of elevated compaction risk. These findings provide a decision-ready baseline to support sustainable groundwater management, including enhanced monitoring, targeted demand controls, and managed aquifer-recharge trials. Full article

Arsenic (As) toxicity drives the evolution of resistance mechanisms in environmental microorganisms. Bacteria of the Bacillus genus are frequently identified in isolates from arsenic-contaminated sites, highlighting the importance of understanding the molecular mechanisms related to this bacterial genus. Bacillus subtilis, a soil microorganism and Gram-positive model paradigm, employs multiple strategies to counteract As toxicity, including biosorption, redox transformation, active efflux, and inducible genetic regulation. This review provides a comprehensive analysis of the physiological and molecular mechanisms involved in arsenic response in B. subtilis and related species, focusing on the ars and ase operons. The ars operon, located within the mobile SKIN element, encodes a reductase (ArsC), an Acr3-type efflux pump (ArsB), a carbon–arsenic lyase (ArsI/YqcK), and a transcriptional repressor (ArsR), all co-regulated in response to arsenic. In turn, the ase operon contributes to resistance via an ArsB-type efflux system (AseA) and its own regulatory protein (AseR) but lacks an arsenate reductase. Additionally, genes such as aioAB, arrAB, and arsD are discussed, along with evidence for extracellular detoxification and cell surface immobilization of As. Studies on environmental Bacillus species are examined, pointing out the evolutionary implications of As resistance and the biotechnological potential for remediation of contaminated sites. Full article

Endometrial cancer is one of the most common malignancies of the female reproductive system, with incidence rising globally due to population ageing and life-style-related risk factors. Calcium (Ca²⁺) is a ubiquitous second messenger regulating diverse physiological processes, and its dysregulation has been increasingly implicated in carcinogenesis, including endometrial. Altered expression and function of Ca²⁺ channels, pumps, exchangers, and binding proteins disrupt the finely tuned balance of Ca²⁺ influx, efflux, and intracellular storage, leading to aberrant signalling that promotes tumour proliferation, migration, survival, and metastasis. This review summarises current knowledge on the molecular “Ca²⁺ toolkit” in the human uterus, highlighting the role of voltage-gated calcium channels (VGCCs), transient receptor potential (TRP) channels, store-operated calcium entry (SOCE) components, Na⁺/Ca²⁺ exchangers, purinergic receptors, P-type ATPases (SERCA, SPCA, PMCA), ryanodine (RyR) and inositol 1,4,5-trisphosphate (IP₃R) receptors, and mitochondrial Ca²⁺ uniporter (MCU) complexes in endometrial cancer progression. Multiple Ca²⁺-handling proteins, including CACNA1D, CACNA2D1, TRPV4, TRPV1, TRPM4, MCU, and RyR1, exhibit cancer-associated overexpression or functional changes, correlating with poor prognosis and aggressive disease features. Emerging evidence supports the therapeutic potential of targeting Ca²⁺ homeostasis using small-molecule inhibitors, ion channel modulators or gene-silencing strategies. These interventions may restore Ca²⁺ balance, induce apoptosis or autophagy, and suppress metastatic behaviour. While no clinical trials have yet explicitly focused on Ca²⁺ modulation in endometrial cancer, the diversity of dysregulated Ca²⁺ pathways offers a rich landscape for novel therapeutic strategies. Targeting key components of the Ca²⁺ signalling network holds promise for improving outcomes in endometrial cancer. Full article