Improved Synthesis of β-D-6-Methylpurine Riboside and Antitumor Effects of the β-D- and α-D-Anomers
Abstract
:Introduction
Results and Discussion
Chemistry
Biological Activity
Cell Line | IC50 (μM) | ||
---|---|---|---|
β-D-MPR | α-D-MPR | ||
A121 (ovarian) | 0.017 | 2.65 | |
A549 (non-small cell lung) | 0.006 | 1.47 | |
HT-29 (colon) | 0.034 | 4.83 | |
MCF7-S (breast) | 0.012 | 1.75 | |
MCF7-R (breast) | 0.026 | 4.08 |
Conclusions
Experimental
General.
Biology
Acknowledgements
References
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Marasco, C., Jr.; Pera, P.; Spiess, A.; Bernacki, R.; Sufrin, J. Improved Synthesis of β-D-6-Methylpurine Riboside and Antitumor Effects of the β-D- and α-D-Anomers. Molecules 2005, 10, 1015-1020. https://doi.org/10.3390/10081015
Marasco C Jr., Pera P, Spiess A, Bernacki R, Sufrin J. Improved Synthesis of β-D-6-Methylpurine Riboside and Antitumor Effects of the β-D- and α-D-Anomers. Molecules. 2005; 10(8):1015-1020. https://doi.org/10.3390/10081015
Chicago/Turabian StyleMarasco, C., Jr., P. Pera, A. Spiess, R. Bernacki, and J. Sufrin. 2005. "Improved Synthesis of β-D-6-Methylpurine Riboside and Antitumor Effects of the β-D- and α-D-Anomers" Molecules 10, no. 8: 1015-1020. https://doi.org/10.3390/10081015