Sulfated Zirconia-Catalyzed Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) Under Solventless Conditions: Competitive Multicomponent Biginelli vs. Hantzsch Reactions
Abstract
:Introduction
Results and Discussion
Surface area | 105.73 m2·g-1 |
Entry | R | X | 4 Yield (%) |
---|---|---|---|
1 | C6H5 | O | 94 |
2 | 2-(CH3)C6H4 | O | 80 |
3 | 4-(CH3)C6H4 | O | 80 |
4 | 5-(CH3)-2-Furyl | O | 83 |
5 | C6H5 | S | 98 |
6 | 2-(CH3)C6H4 | S | 90 |
7 | 4-(CH3)C6H4 | S | 86 |
8 | 4-(OCH3)C6H4 | S | 98 |
9 | 2-Furyl | S | 88 |
Entry | R | Yield (%) | |||
4 | 5 | 4 | 5 | ||
100°C | 150°C | ||||
1 | C6H5 | 84 | 10 | 52 | 41 |
2 | 2-(CH3)C6H4 | 78 | 16 | 35 | 16 |
3 | 4-(CH3)C6H4 | 71 | 6 | 42 | 51 |
4 | 5-(CH3)-2-Furyl | 50 | 32 | 25 | 64 |
5 | 2-Furyl | 59 | 20 | 34 | 63 |
6 | 2-(OCH3)C6H4 | 70 | 21 | 22 | 57 |
7 | 4-(OCH3)C6H4 | 57 | 5 | 57 | 37 |
Conclusions
Experimental
General
Procedure for the preparation of sulfated zirconia catalysts.
General procedure for the synthesis of DHPs (4) and DHMPs (5).
Acknowledgements
References
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- Sample Availability: Available from the authors.
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Angeles-Beltrán, D.; Lomas-Romero, L.; Lara-Corona, V.H.; González-Zamora, E.; Negrón-Silva, G. Sulfated Zirconia-Catalyzed Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) Under Solventless Conditions: Competitive Multicomponent Biginelli vs. Hantzsch Reactions. Molecules 2006, 11, 731-738. https://doi.org/10.3390/11100731
Angeles-Beltrán D, Lomas-Romero L, Lara-Corona VH, González-Zamora E, Negrón-Silva G. Sulfated Zirconia-Catalyzed Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) Under Solventless Conditions: Competitive Multicomponent Biginelli vs. Hantzsch Reactions. Molecules. 2006; 11(10):731-738. https://doi.org/10.3390/11100731
Chicago/Turabian StyleAngeles-Beltrán, Deyanira, Leticia Lomas-Romero, Victor H. Lara-Corona, Eduardo González-Zamora, and Guillermo Negrón-Silva. 2006. "Sulfated Zirconia-Catalyzed Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) Under Solventless Conditions: Competitive Multicomponent Biginelli vs. Hantzsch Reactions" Molecules 11, no. 10: 731-738. https://doi.org/10.3390/11100731