Application of the Solid-Phase Julia–Lythgoe Olefination in Vitamin D Side-Chain Construction
Abstract
:Introduction
Results and Discussion
Conclusions
Experimental
General
Synthesis
(a) Potassium thiolate of thiophenol resin 2
(b) Substition of tosylate 3
(c) (1S,3aR,4S,7aS)-4-(tert-Butyldimethylsilyl)oxy-7a-methyl-1-[(1S)-1-methyl-2-(phenylsulfonyl)-ethyl]octahydro-1H-indene (4) [13]
(d) α-Sulfonyl carbanion of sulfone 4
(e) (1R,3aR,4S,7aR)-1-[(1S)-3-Benzoyloxy-1,5-dimethyl-2-(phenylsulfonyl)hex-4-en-1-yl]-4-(tert-butyldimethylsilyl)oxy-7a-methyloctahydro-1H-indene (5)
(f) (1R,3aR,4S,7aR)-4-(tert-Butyldimethylsilyl)oxy-1-[(1R,2E)-1,5-dimethylhexa-2,4-dien-1-yl]-7a-methyloctahydro-1H-indene (6)
Acknowledgements
References and Notes
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- Sample Availability: No samples available.
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D'herde, J.N.; De Clercq, P.J. Application of the Solid-Phase Julia–Lythgoe Olefination in Vitamin D Side-Chain Construction. Molecules 2006, 11, 655-660. https://doi.org/10.3390/11080655
D'herde JN, De Clercq PJ. Application of the Solid-Phase Julia–Lythgoe Olefination in Vitamin D Side-Chain Construction. Molecules. 2006; 11(8):655-660. https://doi.org/10.3390/11080655
Chicago/Turabian StyleD'herde, Jo N., and Pierre J. De Clercq. 2006. "Application of the Solid-Phase Julia–Lythgoe Olefination in Vitamin D Side-Chain Construction" Molecules 11, no. 8: 655-660. https://doi.org/10.3390/11080655