Next Article in Journal
Overexpression of the Pdx-1 Homeodomain Transcription Factor Impairs Glucose Metabolism in Cultured Rat Hepatocytes
Previous Article in Journal
Anti-carcinogenic Effects of the Flavonoid Luteolin
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Communication

Diastereoselective Synthesis of Cyclopentanediols by InCl3/Al Mediated Intramolecular Pinacol Coupling Reaction in Aqueous Media

1
Department of Chemistry, Zhejiang University, Hangzhou, 310027, P.R. China
2
Zhejiang Hisun Pharm. Co. Ltd. Taizhou, 318000, P.R. China
*
Author to whom correspondence should be addressed.
Molecules 2008, 13(10), 2652-2658; https://doi.org/10.3390/molecules13102652
Submission received: 2 August 2008 / Revised: 14 October 2008 / Accepted: 15 October 2008 / Published: 27 October 2008

Abstract

:
A “green” and practical intramolecular pinacol coupling reaction promoted by InCl3/Al catalysts in aqueous media has been developed. Under mild conditions, a novel class of polysubstituted cyclopentane-1,2-diols have been obtained with excellent diastereoselectivity.

Graphical Abstract

Introduction

In organic synthesis, the formation of carbon-carbon bonds is one of the most fundamental and important operations in the construction of functional molecules. Pinacol coupling, which involves the homo- or cross reductive dimerization of two carbonyls represents one of the most classical ways of generating carbon-carbon bonds [1]. Since its discovery in 1859 [2], the pinacol coupling reaction has been a focal point in synthetic chemistry not only for its carbon-carbon bond generating power, but also for the wide utility of the 1,2-diols obtained from these reactions. These 1,2-diols are valuable synthons in the synthesis of biologically active natural products or molecular fragments [3,4].
After the first report over a century ago, numerous modified pinacol coupling methods have been developed. Instead of the early use of sodium as catalyst, a variety of other metals or metal/Lewis acids such as Zn [5], Mg [6], Ti [7], Sm [8,9], Cr [10], In [11], and VCl3/Al [12], etc. have been proven to be efficient metal sources for pinacol coupling reactions. Hirao et al. [12] reported the main pinacol coupling protocol that is successful in water. Recently, another water-mediated pinacol coupling process has been reported by Hosono and co-workers [13]. However, most of the reported catalyst systems have unfavorable properties due to the toxicity of the metal catalyst(s) and/or the use of toxic organic solvents as reaction media. Therefore, environmentally benign methodologies to produce this valuable reaction are highly desirable. Unlike the corresponding intermolecular reactions, intramolecular pinacol coupling reactions furnish cyclized diols, which usually limits their applications [14]. Much fewer systematic intramolecular pinacol coupling methods are available than their intermolecular counterparts [15,16].
Indium as a nontoxic metal has been extensively studied due to its versatile catalytic activity and tolerance to water and air. A number of organic reactions have been successfully achieved in water or in aqueous media employing indium or indium salts as catalysts [17,18]. It is also our interest to explore broader application of indium as a practical metal catalyst [19,20,21]. In our previous work studying indium catalysis, we developed InCl3/Al catalyzed pinacol coupling reactions in aqueous media, in which a class of vicinal diols derived from aromatic aldehydes, ketones and aldehyde-ketone cross coupling have been synthesized in good yields [22]. In order to further explore the scope of this catalyst system, we have also investigated the intramolecular coupling reactions of 1,5-dicarbonyl substrates, and we present here our results from this study.

Results and Discussion

Screening of reaction temperature

Based on the results of our intermolecular pinacol coupling method, we applied the InCl3/Al co-catalyst system to the intramolecular coupling reaction of 1,3,5-triphenylpentane-1,5-dione, which contains a 1,5-dicarbonyl skeleton. At the presence of 1 equivalent mol InCl3 (0.5 mol scale) and 3.5 equivalent mol of aluminum powder, the substrate was heated at 80 oC for 8 h in 4 mL EtOH/H2O (1:1) to gave the target diol 2a in 51 % isolated yield. We then optimized the temperature on this model reaction, and found that at 70 oC, the pinacol coupling product was formed as the main product after 8 h, and it could be isolated in 65 % yield with column chromatography on silica gel. It is noteworthy that at room temperature, the reaction also proceeded well, but much longer time is required for satisfactory conversion.

Investigation of the scope of the InCl3/Al catalyzed intramolecular pinacol coupling

With the proper conditions in hand, we than turned to examine the scope of application of this protocol for the intramolecular pinacol coupling reaction. A group of 1,5-dicarbonyl substrates analogous to 1,3,5-triphenylpentane-1,5-diketone were subjected to the reaction. The representative results are summarized in Table 1. Symmetrical aromatic 1,5-diketones with diversified functional groups furnished the corresponding five-membered vicinal 1,2-diols in moderate to good yields. While alkyl, alkoxy as well as halogen substitutions were tolerated by this catalyst system, the amino group didn’t give the expected product. Unsymmetrical 1,5-diketones and 1,4-ketones (entries 13 and 14) were also subjected to the reaction conditions, but unfortunately none of the corresponding pinacols were observed under the standard conditions. What should be noted is that most of the substrates gave the corresponding diols with excellent diastereoselectivity, as only one diastereoisomer was observed after chromatography purification. However, the highly symmetrical structure of the products and the lack of vicinal hydrogen atom make it impossible to identify their relative configuration by 1H-NMR [23]. Further work on this issue is presently in progress in our group.
Figure 1. Intramolecular pinacol coupling of aromatic 1,5-diketones.
Figure 1. Intramolecular pinacol coupling of aromatic 1,5-diketones.
Molecules 13 02652 g001
Table 1. InCl3/Al mediated intramolecular pinacol coupling or various aromatic 1,5-diketones.a
Table 1. InCl3/Al mediated intramolecular pinacol coupling or various aromatic 1,5-diketones.a
EntryDiketoneProductYield (%)bd. e. (%)c
R1R2
1HH2a65> 99
2H4-CH32b78> 99
3H4-CH3O2c7558
4H4-Cl2d62> 99
54-CH3H2e80> 99
64-ClH2f83> 99
74-CH3OH2g88> 99
82-ClH2h6144
94-CH34-CH32i90> 99
104-FH2j79> 99
114-N(CH3)2H-trace-
12 Molecules 13 02652 i001---
13d
14e Molecules 13 02652 i002nr
a Reaction conditions: 0.5 mmol 1, 0.5 mmol InCl3, 1.8 mmol aluminum powder and 0.5 g NH4Cl mixed in 4 mL solvent (VEtOH:VH2O=1:1) and stirred at 70 oC for 8 h. b Isolated yield. c Diastereomeric excess was calculated from the 1H-NMR of products based on clearly distinguishable signals. d Complex mixture of reduced products were formed in the reaction, but no target diol was observed in the reaction mixture by ESI-MS. e No conversion was observed.

Experimental

General

All 1,5-dicarbonyl compounds were synthesized following literature procedures [24,25]. InCl3·4H2O was dehydrated by reflux in SOCl2 prior to use, and all other chemicals used in the experiments were obtained from commercial sources and used without further purification. The reactions were carried out under an open atmosphere. Melting points were determined using an XT-4 apparatus and were not corrected. 1H- and 13C-NMR spectra were recorded in CDCl3 on a Bruker AVANCE DMX-500 spectrometer at 500 and 125 MHz, respectively. Chemical shifts are reported in ppm (δ), relative to an internal tetramethylsilane (TMS) standard. Mass spectra were recorded on a Bruker Esquire 3000plus mass spectrometer (Bruker-Franzen Analytik GmbH Breman, Germany) equipped with an ESI interface and ion trap analyzer.

General procedure of the intramolecular pinacol coupling reaction

1,5-Dicarbonyl compound (0.5 mmol), InCl3 (0.5 mmol), Al powder (1.8 mmol) and NH4Cl (0.5 g) were placed in a vessel, mixed solvent (H2O: EtOH=1:1, 4 mL) was added and the mixture was stirred at 70 oC for 8 h. The completion of the reaction was monitored with TLC. After cooling down to rt, the mixture was extracted with ethyl ether (3×10 mL). The combined organic layer was dried overnight with anhydrous sodium sulphate. After removal of solvent, the residue was subjected to silica gel chromatography to give the corresponding product.
1,2,4-Triphenylcyclopentane-1,2-diol (2a). White solid; m.p. 133-135 oC; 1H-NMR: δ = 7.34 (d, 4H, J = 5.5 Hz), 7.25 (t, 1H, J = 6.0 Hz), 7.00 (t, 10H, J = 8.0), 4.06-3.98 (m, 1H), 3.41 (s, 2H), 2.75 (dd, 2H, J1 = 10.4 Hz, J2 = 3.4 Hz), 2.52 (dd, 2H, J1 = 8.9 Hz, J2 = 5.0 Hz); 13C-NMR: δ = 144.4, 143.4, 128.8, 127.6, 127.5, 127.4, 127.3, 127.1, 85.8, 46.5, 38.7; IR (KBr, cm-1): 3420, 3310, 3026, 2924, 1496, 1278, 1191, 940. ESI-MS [M+Na]+: m/z 353. HRMS: Calcd. for C23H22O2Na [M+Na]+: 353.1512; Found, 353.1513.
4-Phenyl-1,2-dip-tolylcyclopentane-1,2-diol (2b). White solid; m.p. 155-157 oC; 1H-NMR: δ = 7.32 (d, 4H, J = 5.7 Hz) 7.20 (t, 1H, J = 5.9 Hz), 6.87 (d, 4H, J = 8.0 Hz), 6.77 (d, 4H, J = 7.9 Hz), 4.02-3.97 (m, 1H), 3.28 (s, 2H), 2.72 (dd, 2H, J1 = 10.2 Hz, J2 = 3.5 Hz), 2.51 (dd, 2H, J1 = 9.0 Hz, J2 = 4.9 Hz), 2.09 (s, 6H); 13C-NMR: δ = 144.6, 140.5, 136.5, 128.8, 128.3, 127.3, 126.5, 126.4, 85.7, 45.8, 38.5, 21.2; IR (KBr, cm-1): 3467, 3301, 1922, 1514, 1281, 1190, 941; ESI-MS [M+Na]+: m/z 381; HRMS: Calcd. for C25H26O2Na [M+Na]+: 381.1825; Found, 381.1828.
1,2-bis(4-Methoxyphenyl)-4-phenylcyclopentane-1,2-diol (2c). White solid; m.p. 128-129 oC; 1H-NMR: δ = 7.28 (d, 4H, J = 6.5 Hz), 6.83 (t, 2H, J = 8.0 Hz), 6.52-6.47 (m, 7H); 3.93-3.80 (m, 1H), 3.69 (s, 2H), 3.38 (s, 6H), 2.64 (dd, 2H, J1 = 10.0 Hz, J2 = 3.8 Hz), 2.43 (dd, 2H, J1 = 9.0 Hz, J2 = 4.9 Hz); 13C-NMR: δ =144.9, 128.9, 127.9, 127.2, 126.2, 119.0, 113.1, 112.8, 111.5, 85.6, 55.2, 45.2, 38.3. IR (KBr, cm-1): 3466, 3303, 2926, 1601, 1489, 1290, 1169, 1047, 962; ESI-MS [M+Na]+: m/z 413; HRMS: Calcd. for C25H26O4Na [M+Na]+: 413.1723; Found, 413.1714.
1,2-bis(4-Chlorophenyl)-4-phenylcyclopentane-1,2-diol (2d). White solid; m.p. 147-150 oC; 1H-NMR: δ= 7.43-7.38 (m, 4H), 7.32 (t, 1H, J = 6.8 Hz), 7.05 (d, 4H, J = 8.6 Hz), 7.00 (d, 4H, J = 8.6 Hz), 4.14-4.06 (m, 1H), 3.38 (s, 2H), 2.76 (dd, 2H, J1 = 10.0 Hz, J2 = 3.9 Hz), 2.60 (dd, 2H, J1 = 9.0 Hz, J2 = 5.0 Hz); 13C-NMR: δ = 143.9, 141.7, 133.3, 129.0, 127.9, 127.8, 127.2, 126.7, 85.4, 45.5, 38.4; IR (KBr, cm-1): 3462, 3292, 1949, 1600, 1493, 1278, 1095, 939; ESI-MS [M+Na]+: m/z 421; HRMS: Calcd. for C23H20Cl2O2Na [M+Na]+: 421.0733; Found, 421.0717.
1,2-Diphenyl-4-p-tolylcyclopentane-1,2-diol (2e). White solid; m.p. 145-147 oC; 1H-NMR: δ = 7.20 (d, 2H, J = 8.0 Hz), 7.11 (d, 2H, J = 10.0 Hz), 6.96-6.90 (m, 10H), 4.00-3.93 (m, 1H), 3.27 (s, 2H), 2. 71 (dd, 2H, J1 = 10.2 Hz, J2 = 4.0 Hz), 2.48 (dd, 2H, J1 = 8.8 Hz, J2 = 5.5 Hz), 2.27 (s, 3H); 13C-NMR: δ = 143.7, 141.6, 136.2, 129.8, 127.8, 127.4, 127.3, 126.7, 86.2, 46.1, 38.6, 21.5; IR (KBr, cm-1): 3470, 3300, 2923, 1516, 1369, 1058, 943; ESI-MS [M+Na]+: m/z 367. HRMS Calcd. for C24H24O2Na [M+Na]+: 367.1669; Found, 367.1661.
4-(4-Chlorophenyl)-1,2-diphenylcyclopentane-1,2-diol (2f). White solid; m.p. 142-145 oC; 1H-NMR : δ = 7.29 (d, 2H, J = 8.1 Hz), 7.24 (d, 2H, J = 8.1 Hz), 6.94 (s, 10H), 3.97-3.93 (m, 1H), 3.46 (s, 2H), 2.66 (dd, 2H, J1 = 10.7 Hz, J2 = 1.6 Hz), 2.48 (dd, 2H, J1 = 9.1 Hz, J2 = 4.4 Hz); 13C-NMR: δ = 143.2, 142.9, 132.1, 128.9, 128.6, 127.6, 127.2, 126.4, 85.8, 45.4, 38.1; IR (KBr, cm-1): 3467, 3294, 2922, 1493, 1092, 1014, 945; ESI-MS [M+Na]+: m/z 387; HRMS: Calcd. for C23H21ClO2Na [M+Na]+: 387.1122; Found, 387.1122.
4-(4-Methoxyphenyl)-1,2-diphenylcyclopentane-1,2-diol (2g). White solid; m.p. 122-125 oC; 1H-NMR: δ = 7.36 (d, 2H, J = 8.5 Hz), 7.25 (d, 2H, J = 9.5 Hz), 7.09-7.02 (m, 8H), 6.97 (d, 2H, J = 8.6 Hz), 4.10-4.03 (m, 1H), 3.86 (s, 3H), 3.39 (s, 2H), 2.80 (dd, 2H, J1 = 10.2 Hz, J2 = 3.9 Hz), 2.60 (dd, 2H, J1 =8.8 Hz, J2 = 5.4 Hz); 13C-NMR: δ = 143.2, 142.3, 131.9, 128.2, 127.6, 127.1, 126.5, 114.2, 86.1, 55.6, 46.0, 38.0; IR (KBr, cm-1): 3464, 3300, 2952, 1610, 1514, 1180, 1059, 938; ESI-MS [M+Na]+: m/z 383; HRMS: Calcd. for C24H24O3Na [M+Na]+: 383.1618; Found, 383.1608.
4-(2-Chlorophenyl)-1,2-diphenylcyclopentane-1,2-diol (2h). White solid; m.p. 132-135 oC; 1H-NMR: δ = 7.48 (d, 1H, J = 8.0 Hz), 7.40-7.38 (m, 1H), 7.30-7.27 (m, 1H), 7.10-7.08 (m, 1H), 7.01-6.98 (m, 10H), 4.36-4.27 (m, 1H), 3.34 (s, 2H), 2.70 (dd, 2H, J1 = 10.2 Hz, J2 = 3.8 Hz), 2.56 (dd, 2H, J1 = 8.7 Hz, J2 = 5.4 Hz); 13C-NMR: δ = 143.2, 130.3, 129.4, 128.6, 127.8, 127.5, 127.4, 127.1, 126.7, 126.5, 85.6, 44.1, 36.7; IR (KBr, cm-1): 3549, 3462, 3061, 2981, 1601, 1489, 1083, 941; ESI-MS [M+Na]+: m/z 387; HRMS: Calcd. for C23H21ClO2Na [M+Na]+: 387.1122; Found, 387.1113.
1,2,4-tri-p-Tolylcyclopentane-1,2-diol (2i). White solid; m.p. 146-149 oC; 1H-NMR: δ = 7.21 (d, 2H, J = 7.8 Hz), 7.12 (d, 2H, J = 7.8 Hz), 6.86 (d, 4H, J = 8.2 Hz), 6.76 (d, 4H, J =8.0 Hz), 3.95-3.91 (m, 1H), 3.31 (s, 2H), 2.66 (dd, 2H, J1 = 10.1 Hz, J2 = 3.7 Hz), 2.45 (dd, 2H, J1 = 9.0 Hz, J2 = 4.9 Hz), 2.30 (s, 3H), 2.12 (s, 6H); 13C-NMR: δ = 141.5, 140.6, 136.5, 135.8, 129.4, 128.2, 127.2, 126.5, 85.7, 45.8, 38.1, 21.3, 21.2; IR (KBr, cm-1): 3469, 3283, 3026, 2920, 1514, 1190, 1022, 943; ESI-MS [M+Na]+: m/z 395. HRMS: Calcd. for C26H28O2Na [M+Na]+: 395.1982; Found, 395.1974.
4-(4-Fluorophenyl)-1,2-diphenylcyclopentane-1,2-diol (2j). White solid; m.p. 163-165 oC; 1H-NMR: δ = 7.68 (d, 2H, J = 8.0 Hz), 7.54 (d, 2H, J = 8.0 Hz), 7.05 (d, 10H, J = 5.1 Hz), 4.18-4.14 (m, 1H), 3.48 (s, 2H), 2.83 (dd, 2H, J1 = 10.3 Hz, J2 = 3.5 Hz), 2.65 (dd, 2H, J1 = 8.9 Hz, J2 = 5.0 Hz); 13C-NMR: δ = 147.3, 143.1, 127.7, 127.6, 127.3, 126.4, 125.8, 125.7, 85.7, 45.4, 38.6; IR (KBr, cm-1): 3450, 3185, 2930, 1510, 1089, 943; ESI-MS [M+Na]+: m/z 371; HRMS: Calcd. for C23H21FO2Na [M+Na]+: 371.1418; Found, 371.1423.

Acknowledgements

This work was financially supported by the Natural Science Foundation of China (grant no. 20775069).

References

  1. Kahn, B. E.; Rieke, R. D. Carbonyl coupling reactions using transition metals, lanthanides, and actinides. Chem. Rev. 1988, 88, 733–745. [Google Scholar] [CrossRef]
  2. Fittig, R. Ueber einige metamorphosen des acetones de essigisäure. Justus Leibigs Ann. Chem. 1859, 110, 13–45. [Google Scholar]
  3. McMurry, J. E.; Rico, J. G.; Shih, Y. N. Synthesis and stereochemistry of sarcophytol B: An anticancer cembranoid. Tetrahedron Lett. 1989, 30, 1173–1176. [Google Scholar] [CrossRef]
  4. McMurry, J. E.; Dushin, R. G. Total synthesis of (+-)-isolobophytolide and (+-)-crassin by tatanium-induced carbonyl coupling. J. Am. Chem. Soc. 1990, 112, 6942–6949. [Google Scholar] [CrossRef]
  5. Li, T.-Y.; Cui, W.; Liu, J.-G.; Zhao, J.-Z.; Wang, Z.-M. A highly dl-stereoselective pinacolization of aromatic aldehydes mediated by TiCl4-Zn. Chem. Commun. 2000, 139–140. [Google Scholar]
  6. Handy, S. T.; Omune, D. A. Chelation effect on the pathway between intramolecular hydrodimerization and pinacol coupling. Org. Lett. 2005, 7, 1553–1555. [Google Scholar] [CrossRef]
  7. Yamamoto, Y.; Hattori, R.; Itoh, K. Highly trans-selective intramolecular pinacol coupling of diols catalyzed bulky Cp2TiPh. Chem. Commun. 1999, 825–826. [Google Scholar] [CrossRef]
  8. Ueda, T.; Kanomata, N.; Machida, H. Synthesis of planar-chiral paracyclophanes via samarium (II)-catalyzed intramolecular pinacol coupling. Org. Lett. 2005, 7, 2365–2368. [Google Scholar] [CrossRef]
  9. Molander, G. A.; Kenny, C. Intramolecular reductive coupling reactions promoted by samarium diiodide. J. Am. Chem. Soc. 1989, 111, 8236–8246. [Google Scholar] [CrossRef]
  10. Svatos, A.; Boland, W. Reductive pinacol coupling reactions of aromatic carbonyl compounds catalytic in chromium(II). Synlett. 1998, 549. [Google Scholar] [CrossRef]
  11. Nair, V.; Ros, S.; Jayan, C. N.; Rath, N. P. Indium/indium trichloride mediated pinacol cross-coupling reaction of aldehydes and chalcones in aqueous media: a facile stereoselective synthesis of substituted but-3-ene-1,2-diols. Tetrahedron Lett. 2002, 43, 8967–8969. [Google Scholar] [CrossRef]
  12. Xu, X.; Hirao, T. Vanadium-catalyzed pinacol coupling reaction in water. J. Org. Chem. 2005, 70, 8594–8596. [Google Scholar] [CrossRef]
  13. Buchammagari, H.; Toda, Y.; Hirano, M.; Hososno, H.; Takeuchi, D.; Osakada, K. Room temperature-stable electride as a synthetic organic reagent: application to pinacol coupling reaction in aqueous media. Org. Lett. 2007, 9, 4287–4289. [Google Scholar] [CrossRef]
  14. Corey, E. J.; Danheiser, R. L.; Chandrasekaran, S. New reagent for the intermolecular and intramolecular pinacolic coupling of ketones and aldehydes. J. Org. Chem. 1976, 41, 260–265. [Google Scholar]
  15. Hays, D. S.; Fu, G. C. Metal hydride mediated intramolecular pinacol couplings of dialdehydes and ketoaldehydes. J. Am. Chem. Soc. 1995, 117, 7283–7284. [Google Scholar] [CrossRef]
  16. Yamamoto, Y.; Hattori, R.; Itoh, K. Highly trans-selective intramolecular pinacol coupling of dials catalyzed by bulky Cp2TiPh. Chem. Commun. 1999, 825–826. [Google Scholar] [CrossRef]
  17. Li, C.-J.; Chan, T.-H. Organic syntheses using indium-mediated and catalyzed reactions in aqueous media. Tetrahedron 1999, 55, 11149–11176. [Google Scholar] [CrossRef]
  18. Auge, J.; Lubin-Germain, N.; Uziel, J. Recent advances in indium-promoted organic reactions. Synthesis 2007, 1739–1764. [Google Scholar]
  19. Wang, C.-Y.; Su, H.; Yang, D.-Y. Regio- and stereoselective dimerization of terminal alkynes to enynes in InCl3-NaBH4 system. Synlett. 2004, 561–563. [Google Scholar]
  20. Wang, C.-Y.; Yan, L.; Zheng, Z.-G.; Yang, D.-Y.; Pan, Y.-J. Synthesis of (E)-alkenes via hydroindation of C=C in InCl3-NaBH4 system. Tetrahedron 2006, 62, 7712–7717. [Google Scholar] [CrossRef]
  21. Wang, C.-Y.; Wan, J.-P.; Zheng, Z.-G.; Pan, Y.-J. A new InCl3-catalyzed reduction of anthrones and anthraquinones by using aluminum powder in aqueous media. Tetrahedron 2007, 63, 5071–5075. [Google Scholar] [CrossRef]
  22. Wang, C.-Y.; Pan, Y.-J.; Wu, A.-X. InCl3/Al mediated pinacol coupling reactions of aldehydes and ketones in aqueous media. Tetrahedron 2007, 63, 429–434. [Google Scholar] [CrossRef]
  23. Hirsch, S. S.; Bailey, W. J. Base-catalyzed alkylation of cyclopentadiene rings with alcohols and amines. J. Org. Chem. 1978, 43, 4090. [Google Scholar] [CrossRef]
  24. Yanagisawa, A.; Takahashi, H.; Arai, T. One-pot synthesis of 1,5-diketones catalyzed by barium isopropoxide. Tetrahedron 2007, 63, 8581–8585. [Google Scholar] [CrossRef]
  25. Rong, L.-C.; Li, X.-Y.; Wang, H.-Y.; Shi, D.-Q.; Tu, S.-J. Solvent-free Michael addition reaction of cyclohexanone with chalcone. Chin. J. Org. Chem. 2007, 27, 1292–1295. [Google Scholar]
  • Sample Availability: Samples of compounds 2a-2j are available from the authors.

Share and Cite

MDPI and ACS Style

Chen, Y.; Wan, J.; Wang, C.; Sun, C. Diastereoselective Synthesis of Cyclopentanediols by InCl3/Al Mediated Intramolecular Pinacol Coupling Reaction in Aqueous Media. Molecules 2008, 13, 2652-2658. https://doi.org/10.3390/molecules13102652

AMA Style

Chen Y, Wan J, Wang C, Sun C. Diastereoselective Synthesis of Cyclopentanediols by InCl3/Al Mediated Intramolecular Pinacol Coupling Reaction in Aqueous Media. Molecules. 2008; 13(10):2652-2658. https://doi.org/10.3390/molecules13102652

Chicago/Turabian Style

Chen, Yunhua, Jieping Wan, Chunyan Wang, and Cuirong Sun. 2008. "Diastereoselective Synthesis of Cyclopentanediols by InCl3/Al Mediated Intramolecular Pinacol Coupling Reaction in Aqueous Media" Molecules 13, no. 10: 2652-2658. https://doi.org/10.3390/molecules13102652

Article Metrics

Back to TopTop