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10.3390/molecules14010573
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Article

Antiosteoporotic Activity of Anthraquinones from Morinda officinalis on Osteoblasts and Osteoclasts

by
Yan-Bin Wu
1,2,
Cheng-Jian Zheng
2,
Lu-Ping Qin
2,
Lian-Na Sun
2,
Ting Han
2,
Lei Jiao
2,
Qiao-Yan Zhang
2,* and
Jin-Zhong Wu
3,*
1
Department of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350108, P.R. China
2
Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, P.R. China
3
Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350108, P.R. China
*
Authors to whom correspondence should be addressed.
Molecules 2009, 14(1), 573-583; https://doi.org/10.3390/molecules14010573
Submission received: 16 December 2008 / Revised: 17 January 2009 / Accepted: 22 January 2009 / Published: 23 January 2009
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Abstract

Bioactivity-guided fractionation led to the successful isolation of antiosteoporotic components, i.e. physicion (1), rubiadin-1-methyl ether (2), 2-hydroxy-1-methoxy- anthraquinone (3), 1,2-dihydroxy-3-methylanthraquinone (4), 1,3,8-trihydroxy-2-methoxy- anthraquinone (5), 2-hydroxymethyl-3-hydroxyanthraquinone (6), 2-methoxyanthraquinone (7) and scopoletin (8) from an ethanolic extract of the roots of Morinda officinalis. Compounds 4-8 are isolated for the first time from M. officinalis. Among them, compounds 2 and 3 promoted osteoblast proliferation, while compounds 4, 5 increased osteoblast ALP activity. All of the isolated compounds inhibited osteoclast TRAP activity and bone resorption, and the inhibitory effects on osteoclastic bone resorption of compounds 1 and 5 were stronger than that of other compounds. Taken together, antiosteoporotic activity of M. officinalis and its anthraquinones suggest therapeutic potential against osteoporosis.
Keywords: Morinda officinalis; Anthraquinones; Osteoblast; Osteoclast; Osteoporosis Morinda officinalis; Anthraquinones; Osteoblast; Osteoclast; Osteoporosis

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MDPI and ACS Style

Wu, Y.-B.; Zheng, C.-J.; Qin, L.-P.; Sun, L.-N.; Han, T.; Jiao, L.; Zhang, Q.-Y.; Wu, J.-Z. Antiosteoporotic Activity of Anthraquinones from Morinda officinalis on Osteoblasts and Osteoclasts. Molecules 2009, 14, 573-583. https://doi.org/10.3390/molecules14010573

AMA Style

Wu Y-B, Zheng C-J, Qin L-P, Sun L-N, Han T, Jiao L, Zhang Q-Y, Wu J-Z. Antiosteoporotic Activity of Anthraquinones from Morinda officinalis on Osteoblasts and Osteoclasts. Molecules. 2009; 14(1):573-583. https://doi.org/10.3390/molecules14010573

Chicago/Turabian Style

Wu, Yan-Bin, Cheng-Jian Zheng, Lu-Ping Qin, Lian-Na Sun, Ting Han, Lei Jiao, Qiao-Yan Zhang, and Jin-Zhong Wu. 2009. "Antiosteoporotic Activity of Anthraquinones from Morinda officinalis on Osteoblasts and Osteoclasts" Molecules 14, no. 1: 573-583. https://doi.org/10.3390/molecules14010573

APA Style

Wu, Y.-B., Zheng, C.-J., Qin, L.-P., Sun, L.-N., Han, T., Jiao, L., Zhang, Q.-Y., & Wu, J.-Z. (2009). Antiosteoporotic Activity of Anthraquinones from Morinda officinalis on Osteoblasts and Osteoclasts. Molecules, 14(1), 573-583. https://doi.org/10.3390/molecules14010573

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