Farnesol, a Potential Efflux Pump Inhibitor in Mycobacterium smegmatis
Abstract
:Introduction
Results
MIC results
Compound | MIC (μg/mL) | Concentration as modulator (μg/mL) | Modulation factor (EtBr) | FICI |
---|---|---|---|---|
Farnesol | 64 | 8 | 2 | 0.625 |
16 | 8 | 0.375 | ||
32 | 8 | 0.625 | ||
Chlorpromazine | 32 | 8 | 1 | 1.25 |
16 | 4 | 0.75 | ||
Reserpine | 256 | 32 | 2 | 0.625 |
64 | 4 | 0.5 | ||
Verapamil | 300 | 32 | 1 | 1.107 |
64 | 2 | 0.713 | ||
CCCP | 25 | 16 | 2 | 1.14 |
Checkerboard synergy assay results
EtBr efflux inhibition
Discussion
Experimental
Chemicals
Strain and culture conditions
Determination of antibacterial susceptibility
Checkerboard synergy assay
Measurement of EtBr accumulation
Measurement of EtBr efflux
Conclusions
Acknowledgements
- Samples Availability: Samples of the compound farnesol is available from the authors.
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Share and Cite
Jin, J.; Zhang, J.-Y.; Guo, N.; Sheng, H.; Li, L.; Liang, J.-C.; Wang, X.-L.; Li, Y.; Liu, M.-Y.; Wu, X.-P.; et al. Farnesol, a Potential Efflux Pump Inhibitor in Mycobacterium smegmatis. Molecules 2010, 15, 7750-7762. https://doi.org/10.3390/molecules15117750
Jin J, Zhang J-Y, Guo N, Sheng H, Li L, Liang J-C, Wang X-L, Li Y, Liu M-Y, Wu X-P, et al. Farnesol, a Potential Efflux Pump Inhibitor in Mycobacterium smegmatis. Molecules. 2010; 15(11):7750-7762. https://doi.org/10.3390/molecules15117750
Chicago/Turabian StyleJin, Jing, Ji-Yu Zhang, Na Guo, Hui Sheng, Lei Li, Jun-Chao Liang, Xue-Lin Wang, Yang Li, Ming-Yuan Liu, Xiu-Ping Wu, and et al. 2010. "Farnesol, a Potential Efflux Pump Inhibitor in Mycobacterium smegmatis" Molecules 15, no. 11: 7750-7762. https://doi.org/10.3390/molecules15117750