Next Article in Journal
Stereodynamic Investigation of Labile Stereogenic Centres in Dihydroartemisinin
Next Article in Special Issue
Pd(II)/HPMoV-Catalyzed Direct Oxidative Coupling Reaction of Benzenes with Olefins
Previous Article in Journal
Synthesis of syn-γ-Amino-β-hydroxyphosphonates by Reduction of β-Ketophosphonates Derived from L-Proline and L-Serine
Previous Article in Special Issue
Palladium-Catalyzed Heck Coupling Reaction of Aryl Bromides in Aqueous Media Using Tetrahydropyrimidinium Salts as Carbene Ligands
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 15
Issue 3
10.3390/molecules15031303
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Reductive Heck Reactions of N-Methyl-substituted Tricyclic Imides

by
Gokce Goksu
1,
Nuket Ocal
1,* and
Dieter E. Kaufmann
2,*
1
Department of Chemistry, Faculty of Art and Sciences, Davutpasa Campus, Yildiz Technical University, 34210 Esenler-Istanbul, Turkey
2
Institute of Organic Chemistry, Leibnizstr. 6, Clausthal University of Technology, D-38678 Clausthal-Zellerfeld, Germany
*
Authors to whom correspondence should be addressed.
Molecules 2010, 15(3), 1302-1308; https://doi.org/10.3390/molecules15031303
Submission received: 30 January 2010 / Revised: 10 February 2010 / Accepted: 2 March 2010 / Published: 4 March 2010
(This article belongs to the Special Issue Heck Coupling)
Browse Figures
Versions Notes

Abstract

:
The palladium-catalyzed hydroarylation of N-methyl-substituted tricyclic imides was studied in order to find a new stereoselective access to a series of new exo-aryl(hetaryl)-substituted tricyclic N-methylimides.

1. Introduction

The imide moiety is an integral structural part of various important bioactive molecules such as fumaramidmycin, granulatimide, isogranulatimide and rebeccamycin. These molecules are reported to exhibit antitumor, anti-inflammatory and antimicrobial activities [1,2,3]. A literature search reveals that certain compounds with antitumor activity, and in particular molecules able to interact with DNA, are characterized by the presence of both an extended π-system and an imide function.
On the other hand, derivatives of the tricyclic anhydride exo-5,6-dehydronorcantharidin (2, Figure 1) are also pharmacologically active [4]. Norcantharidin shows a comparable activity with cantharidin (1, Figure 1) which is the major effective ingredient in pharmaceuticals for the treatment of certain malignant tumors in China. Compound 2 has been widely employed in clinical practice, as it is less toxic and much easier to synthesize [5,6]. Furthermore, in connection with an additional imide unit this type of structure has recently become an intense research topic in heterocyclic chemistry because of its anti-tumor, anti-virus, analgesic, sedative and fungicidal activities.
Molecules 15 01302 g001 550
Figure 1. Cantharidin (1) and exo-5,6-dehydronorcantharidin (2).
Figure 1. Cantharidin (1) and exo-5,6-dehydronorcantharidin (2).
Molecules 15 01302 g001
Therefore, we became interested in bioactive cantharidin analogues that represent aryl-modified bicyclic imide systems. We first synthesized endo-N-phenylbicyclo[2.2.1]hept-5-ene-2,3-dicarboximide as the starting material for reductive Heck reactions. In the presence of triphenylarsine as a ligand [7] the palladium-catalyzed hydroarylation of the easily accessible, unsaturated tricyclic N-phenyl (or phenyl-substituted) imides has been proven to be a stereoselective, versatile and high-yield approach for the synthesis of the corresponding aryl and heteroaryl derivatives [8,9]. In this paper, we synthesized various N-methyl derivatives of the unsaturated imides by a hydroarylation procedure to check the effect on both, the reactivity of the starting materials as well as the bioactivity of the products.

2. Results and Discussion

Our synthesis started with the Diels-Alder reaction of cyclopentadiene and N-methylmaleimide in dry benzene under reflux to give N-methylbicyclo[2.2.1]hept-5-ene-2-endo,3-endo-dicarboximide (3) as colorless crystals in a yield of 93% [10]. The same reaction was successfully applied to the reaction of furan with N-methylmaleimide to give both diastereomers, N-methyl-7-oxabicyclo[2.2.1]hept-5-ene-2-endo,3-endo-dicarboximide (4) and N-methyl-7-oxabicyclo[2.2.1]hept-5-ene-2-exo,3-exo-di-carboximide (5) in good yieldsafter chromatographic separation [11] (Scheme 1).
Molecules 15 01302 g002 550
Scheme 1. Synthesis of 3–5.
Scheme 1. Synthesis of 3–5.
Molecules 15 01302 g002
Treatment of 3 with 1-iodobenzene, 4-chloro-1-iodobenzene and 2-iodothiophene under reductive Heck conditions gave the 6, 7 and 8 pure products as exo-isomers after chromatographic separation on silica gel in isolated yields of 70–94% (Scheme 2).
Molecules 15 01302 g003 550
Scheme 2. Synthesis of 6–11.
Scheme 2. Synthesis of 6–11.
Molecules 15 01302 g003
The same reductive Heck arylation conditions were successfully applied to the reaction of 4 with 4-methoxy-1-iodobenzene, 2-chloro-1-iodobenzene and 1-iodonaphthalene to give the new exo-arylated heterocycles 9, 10 and 11 in good yields after chromatographic separation (Scheme 2). We also synthesized 12, 13 and 14 from 5 with 2-chloro-5-iodopyridine, 1-iodobenzene and 4-chloro-1-iodobenzene prepared asnew 8-exo-compounds under the same hydroarylation conditions (Scheme 3).
Molecules 15 01302 g004 550
Scheme 3. Synthesis of 12–14.
Scheme 3. Synthesis of 12–14.
Molecules 15 01302 g004
The new structures were assigned by their 1H-NMR data. The stereochemistry was inferred from their NMR spectra including diagnostic spin-spin interactions. The exo-position of the C-8 substituent was confirmed by the fact that H8 showed no significant interaction with H1. The geminal protons at C-9 were identified by vicinal coupling to H1. Additionally, H-H COSY spectra showed cross peaks between H2 and H6 and between H8 and H9, respectively. In addition to the 13C-NMR, DEPT and FTIR spectral data which were in agreement with the proposed structures, the mass spectra of all new compounds showed the expected molecular ion peaks. The data show that independently from the stereochemistry of the starting imide moiety, hydroarylation leads to the formation of the exo-arylated products, exclusively.

3. Experimental Section

3.1. General

All the reactions were carried out under nitrogen atmosphere unless otherwise indicated. Reactions were monitored by thin-layer chromatography (TLC). Visualization of the developed chromatograms were performed either with UV light or KMnO4 stain. Products were purified by silica gel chromatography with a solvent gradient of ethyl acetate/n-hexane to afford the title compounds. IR spectra were obtained with a Perkin Elmer FT-IR instrument and absorption frequencies are reported in cm-1. Melting points were determined with a Gallenkamp digital thermometer. NMR spectra were determined with a Varian-INOVA-500 MHz NMR. 2D NMR experimental studies were measured with a Bruker Ac-400 MHz NMR. TMS (tetramethylsilane) was used as an internal standard and CDCl3 was used as the solvent. Signal multiplicities in the NMR spectra are reported as follows: s-singlet, brs-broad singlet, d-doublet, dd-doublet of doublets, m-multiplet. Mass spectra were measured with Agilent 6890N GC-System-5973 IMSD.

3.2. General procedure for reductive Heck reactions

A solution of Pd(OAc)2 (5.6 mg, 0.025 mmol) and AsPh3 (33.7 mg, 0.11 mmol) in anhydrous DMF (3 mL) was stirred under nitrogen at 65 °C for 15 min. Then, alkene (1.0 mmol), Et3N (488 μL, 3.5 mmol), aryl(hetaryl) iodide (1.5 mmol) and HCOOH (138 mg, 3 mmol) were added sequentially. The reaction mixture was stirred for 8–24 h. After cooling to room temperature EtOAc and brine were added, the organic layer was separated, dried over MgSO4, filtered, and the solvent evaporated. The residue was purified by column chromatography (SiO2).
Molecules 15 01302 i001
N-Methyl-exo-8-phenylbicyclo[2.2.1]heptane-3-endo,5-endo-dicarboximide (6). Colorless solid, m.p. 108–110 °C, yield: 70%. IR (ATR) υ: 3029, 2968, 2891, 1763, 1686, 1601, 1491, 1472, 1449, 1427, 1376, 1273, 1258, 1181, 1118, 979, 770, 746 cm-1; 1H-NMR δ: 1.50 (d, J = 10.7 Hz, 1H, H10a), 1.68 (ddd, J = 15.6, 10.7, 1.9 Hz, 1H, H10s), 1.77–1.83 (m, 2H, H9x and H9n), 2.68 (dd, J = 8.7, 5.8 Hz, 1H, H8n), 2.80–2.84 (m, 2H, H1 and H7), 2.95 (s, 3H, N-CH3), 3.08 (ddd, J = 14.6, 10.7, 1.9 Hz, 1H, H2), 3.14 (dd, J = 8.7, 4.8 Hz, 1H, H6), 7.08–7.13 (m, 3H, Har), 7.19–7.23 (m, 2H, Har) ppm; 13C-NMR δ: 24.65, 32.76, 39.58, 39.82, 42.09, 45.93, 48.76, 49.34, 126.40, 127.26, 128.66, 144.64, 178.34, 178.36 ppm; GC-MS m/z: 255 (M+), 143, 113, 66.
N-Methyl-exo-8-(4-chlorophenyl)bicyclo[2.2.1]heptane-3-endo,5-endo-dicarboximide (7). Colorless solid, m.p. 120–123 °C, yield: 84%. IR (ATR) υ: 2970, 2906, 1768, 1687, 1492, 1454, 1427, 1379, 1275, 1259, 1182, 1138, 1126, 1091, 986, 830, 812, 798 cm-1; 1H-NMR δ: 1.50 (d, J = 9.7 Hz, 1H, H10a), 1.65–1.77 (m, 3H, H10s, H9x and H9n), 2.63–2.67 (m, 1H, H8n), 2.77 (d, J = 4.8 Hz, 1H, H1), 2.82 (brs, 1H, H7), 2.95 (s, 3H, N-CH3), 3.08 (ddd, J = 9.7, 5.8, 2.8 Hz, 1H, H2), 3.14 (dd, J = 9.7, 5.8 Hz, 1H, H6), 7.04 (d, J = 8.7 Hz, 2H, Har), 7.17 (d, J = 8.7 Hz, 2H, Har) ppm; 13C-NMR δ: 24.68, 32.85, 39.52, 39.78, 41.59, 45.88, 48.65, 49.24, 128.60, 128.74, 132.20, 143.12, 178.15, 178.21 ppm; GC-MS m/z: 289 (M+), 177, 152, 138, 113, 66.
N-Methyl-exo-8-(2-thienyl)bicyclo[2.2.1]heptane-3-endo,5-endo-dicarboximide (8). Colorless solid, m.p. 93–96 °C, yield: 94%. IR (ATR) υ: 3068, 2972, 2886, 1762, 1688, 1470, 1430, 1378, 1310, 1272, 1255, 1181, 1119, 1079, 980, 937, 796, 742 cm-1; 1H-NMR δ: 1.54 (d, J = 10.7 Hz, 1H, H10a), 1.76 (brd, J = 5.8 Hz, 2H, H9x and H9n), 1.89 (d, J = 10.7 Hz, 1H, H10s), 2.81 (brd, J = 4.3 Hz, 2H, H1 and H7), 2.87–2.90 (m, 1H, H8n), 2.94 (s, 3H, N-CH3), 3.07 (dd, J = 8.7, 4.8 Hz, 1H, H2), 3.12 (dd, J = 8.7, 4.8 Hz, 1H, H6), 6.71 (d, J = 3.9 Hz, 1H, Har), 6.84 (dd, J = 4.8, 3.4 Hz, 1H, Har), 7.06 (dd, J = 4.8, 0.9 Hz, 1H, Har) ppm; 13C-NMR δ: 24.68, 35.26, 38.27, 39.49, 39.99, 47.26, 48.48, 48.93, 123.56, 123.64, 126.98, 149.61, 178.01, 178.07 ppm; GC-MS m/z: 261 (M+), 149, 113, 66.
N-Methyl-exo-8-(4-methoxyphenyl)-10-oxabicyclo[2.2.1]heptane-3-endo,5-endo-dicarboximide (9). Colorless solid, m.p. 151–153 °C, yield: 91%. IR (ATR) υ: 3041, 2960, 2903, 1766, 1689, 1611, 1512, 1463, 1427, 1374, 1274, 1244, 1180, 1132, 1032, 996, 948, 892, 829 cm-1; 1H-NMR δ: 1.83 (dt, J = 13.6, 4.8 Hz, 1H, H9x), 2.03 (dd, J = 13.6, 8.7 Hz, 1H, H9n), 2.80 (dd, J = 8.7, 4.8 Hz, 1H, H8n), 2.97 (s, 3H, N-CH3), 3.40–3.44 (m, 2H, H2 and H6), 3.70 (s, 3H, -OCH3), 4.65 (brs, 1H, H7), 4.96 (brs, 1H, H1), 6.74 (d, J = 8.7 Hz, 2H, Har), 7.08 (d, J = 8.7 Hz, 2H, Har) ppm; 13C-NMR δ: 25.07, 37.49, 43.96, 51.59, 51.81, 55.48, 78.11, 84.20, 114.18, 128.48, 136.62, 158.72, 175.63, 175.72 ppm; GC-MS m/z: 287 (M+), 259, 147, 68.
N-Methyl-exo-8-(2-chlorophenyl)-10-oxabicyclo[2.2.1]heptane-3-endo,5-endo-dicarboximide (10). Colorless solid, m.p. 122–123 °C, yield: 65%. IR (ATR) υ: 3019, 2973, 2948, 1775, 1693, 1471, 1432, 1379, 1311, 1274, 1129, 994, 954, 835 cm-1; 1H-NMR δ: 1.76–1.80 (m, 1H, H9x), 2.12 (dd, J = 13.6, 8.7 Hz, 1H, H9n), 2.99 (s, 3H, N-CH3), 3.42 (dd, J = 8.7, 4.8 Hz, 1H, H8n), 3.45-3.47 (m, 2H, H2 and H6), 4.80 (brd, J = 4.8 Hz, 1H, H1), 4.98 (brs, 1H, H7), 7.08–7.16 (m, 2H, Har), 7.26 (d, J = 8.7 Hz, 1H, Har), 7.32 (d, J = 8.7 Hz, 1H, Har) ppm; 13C-NMR δ: 23.85, 35.24, 39.43, 50.38, 50.54, 77.10, 81.65, 126.28, 126.44, 126.92, 128.32, 132.45, 140.07, 173.90, 174.37 ppm; GC-MS m/z: 291 (M+), 256, 228, 151, 112, 68.
N-Methyl-exo-8-(1-naphthyl)-10-oxabicyclo[2.2.1]heptane-3-endo,5-endo-dicarboximide (11). Colorless solid, m.p. 170–172 °C, yield: 62%. IR (ATR) υ: 2987, 2964, 1770, 1690, 1597, 1508, 1428, 1375, 1314, 1271, 1136, 1065, 1001, 954, 894, 802, 786 cm-1; 1H-NMR δ: 2.06–2.16 (m, 2H, H9x and H9n), 3.05 (s, 3H, N-CH3), 3.48–3.56 (m, 2H, H2 and H6), 3.72 (dd, J = 8.7, 4.8 Hz, H8n), 4.83 (d, J = 5.8 Hz, 1H, H7), 5.04 (t, J = 5.8 Hz, 1H, H1), 7.36–7.38 (m, 2H, Har), 7.40–7.44 (m, 1H, Har), 7.48–7.51 (m, 1H, Har), 7.66 (d, J = 6.1, 2.9 Hz, 1H, Har), 7.78 (d, J = 8.7 Hz, 1H, Har), 7.86 (d, J = 8.7 Hz, 1H, Har) ppm; 13C-NMR δ: 25.20, 35.22, 39,75, 51.82, 51.83, 78.36, 83.26, 122.92, 123.39, 125.66, 125.93, 126.77, 127.71, 129.23, 131.57, 134.10, 138.74, 175.73, 176.04 ppm; GC-MS m/z: 307 (M+), 167, 152, 112, 68.
N-Methyl-exo-8-(6-chloro-3-pyridinyl)-10-oxabicyclo[2.2.1]heptane-3-exo,5-exo-dicarboximide (12). Colorless solid, m.p. 202–204 °C, yield: 41%. IR (ATR) υ: 3060, 2993, 1770, 1688, 1566, 1454, 1433, 1381, 1282, 1266, 1130, 1028, 1003, 887, 828, 784 cm-1; 1H-NMR δ: 1.80 (dt, J = 13.1, 4.8 Hz, 1H, H9x), 2.20 (dd, J = 13.1, 8.7 Hz, 1H, H9n), 2.91 (s, 3H, N-CH3), 2.95 (d, J = 6.8 Hz, 1H, H2), 2.98 (d, J = 4.8 Hz, 1H, H8n), 3.00 (d, J = 6.8 Hz, 1H, H6), 4.68 (s, 1H, H7), 4.98 (d, J = 5.3 Hz, 1H, H1), 7.22 (s, 1H, Har), 7.53 (dd, J = 8.7, 2.4 Hz, 1H, Har), 8.18 (d, J = 2.4 Hz, 1H, Har) ppm; 13C-NMR δ: 25.38, 40.29, 44.35, 49.86, 50.12, 79.21, 84.51, 124.72, 137.51, 138.74, 148.74, 150.42, 176.43, 176.74 ppm; GC-MS m/z: 292 (M+), 180, 153, 117, 68.
N-Methyl-exo-8-phenyl-10-oxabicyclo[2.2.1]heptane-3-exo,5-exo-dicarboximide (13). Colorless solid, m.p. 137–138 °C, yield: 79%. IR (ATR) υ: 3062, 2956, 1768, 1683, 1479, 1431, 1386, 1288, 1136, 1008, 986, 888, 837, 763, 745 cm-1; 1H-NMR δ: 1.89 (dt, J = 12.6, 4.8 Hz, 1H, H9x), 2.15 (dd, J = 12.6, 8.7 Hz, 1H, H9n), 2.90 (s, 3H, N-CH3), 2.91-2.98 (m, 3H, H8n, H2 and H6), 4.72 (s, 1H, H7), 4.93 (d, J = 4.8 Hz, 1H, H1), 7.13–7.17 (m, 3H, Har), 7.19–7.23 (m, 2H, Har) ppm; 13C-NMR δ: 25.29, 40.29, 47.59, 50.01, 50.43, 79.28, 84.92, 127.06, 127.33, 128.90, 144.30, 176.94, 177.25 ppm; GC-MS m/z: 257 (M+), 157, 117, 68.
N-Methyl-exo-8-(4-chlorophenyl)-10-oxabicyclo[2.2.1]heptane-3-exo,5-exo-dicarboximide (14). Colorless solid, m.p. 174–175 °C, yield: 82%. IR (ATR) υ: 2991, 1770, 1692, 1491, 1432, 1376, 1283, 1183, 1131, 1089, 1000, 979, 883, 823, 808, 779 cm-1; 1H-NMR δ: 1.82 (dt, J = 12.6, 4.8 Hz, 1H, H9x), 2.16 (dd, J = 12.6, 8.7 Hz, 1H, H9n), 2.90 (s, 3H, N-CH3), 2.92 (d, J = 6.8 Hz, 1H, H2), 2.94 (d, J = 4.8 Hz, 1H, H8n), 2.96 (d, J = 6.8 Hz, 1H, H6), 4.68 (s, 1H, H7), 4.94 (d, J = 4.8 Hz, 1H, H1), 7.10 (d, J = 8.7 Hz, 2H, Har), 7.18 (d, J = 8.7 Hz, 2H, Har) ppm; 13C-NMR δ: 25.32, 40.35, 46.99, 49.95, 50.30, 79.22, 84.80, 128.70, 129.01, 132.91, 142.80, 176.78, 177.06 ppm; GC-MS m/z: 291 (M+), 191, 151, 112, 68.

4. Conclusions

In summary, in the presence of triphenylarsine as a ligand the palladium-catalyzed hydroarylation of the readily accessible N-substituted tricyclic imides 3, 4 and 5 was shown to be a stereoselective, versatile and high yield approach to the synthesis of aryl and heteroaryl derivatives of tricyclic imides 6–14. The above approach has been proved very useful for the construction of novel heterocycles of potential pharmacological interest.

Acknowledgements

We gratefully acknowledge financial support of this work by the Yildiz Technical University scientific research projects coordination department (Project No. 28-01-02-04).
  • Samples Availability: Samples of the compounds are available from the authors.

References and Notes

  1. Brana, M.F.; Gradillas, A.; Gomez, A.; Acero, N.; Llinares, F.; Munoz-Mingarrro, D.; Abradelo, C.; Rey-Stolle, F.; Yuste, M.; Campos, J.; Gallo, M.A.; Espinosa, A. Synthesis, biological activity, and quantitative structure−activity relationship study of azanaphthalimide and arylnaphthalimide derivatives. J. Med. Chem. 2004, 47, 2236–2242. [Google Scholar]
  2. Sondhi, S.M.; Rani, R.; Roy, P.; Agrawal, S.K.; Saxena, A.K. Microwave-assisted synthesis of N-substituted cyclic imides and their evaluation for anticancer and anti-inflammatory activities. Bioorg. Med. Chem. Lett. 2009, 19, 1534–1538. [Google Scholar]
  3. Kossakowski, J.; Jarocka, M. Synthesis of new N-substituted cyclic imides with an expected anxiolytic activity. XVII. Derivatives of 1-ethoxybicyclo[2.2.2]oct-5-one-2,3-dicarboximide. II Farmaco 2001, 56, 785–789. [Google Scholar]
  4. Hart, M.E.; Chamberlin, A.R.; Walkom, C.; Sakoff, J.A.; McCluskey, A. Modified norcantharidins: synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity. Bioorg. Med. Chem. Lett. 2004, 14, 1969–1973. [Google Scholar] [CrossRef]
  5. Deng, L.; Yongzhou, H. 1,3-Dipolar cycloaddition reaction: synthesis and configuration of norcantharidin derivatives of substituted aromatic amines. J. Heterocycl. Chem. 2007, 44, 597–601. [Google Scholar] [CrossRef]
  6. Deng, L.-P.; Liu, F.-M.; Wang, H.-Y. 1,3-Dipolar cycloaddition reaction: synthesis of novel 5,6-dehydronorcantharidin derivatives of substituted aromatic amines with potential antitumor activities. J. Heterocycl. Chem. 2005, 42, 13–18. [Google Scholar] [CrossRef]
  7. Namyslo, J.C.; Kaufmann, D.E. Triphenylarsine as an efficient ligand in the Pd-catalyzed synthesis of Epibatidine and analogs. Synlett 1999, 114–116. [Google Scholar]
  8. Goksu, G.; Gul, M.; Ocal, N.; Kaufmann, D.E. Hydroarylation of bicyclic, unsaturated dicarboximides: access to aryl-substituted, bridged perhydroisoindoles. Tetrahedron Lett. 2008, 49, 2685–2688. [Google Scholar] [CrossRef]
  9. Celik, C.; Kulu, I.; Ocal, N.; Kaufmann, D.E. Domino-Heck reactions of carba- and oxabicyclic, unsaturated dicarboximides: Synthesis of aryl-substituted, bridged perhydroisoindole derivatives. Helv. Chim. Acta 2009, 92, 1092–1101. [Google Scholar] [CrossRef]
  10. Birney, D.; Lim, T.-K.; Koh, Joanne H.P.; Pool, B.R.; White, J.M. Structural investigations into the retro-Diels-Alder reaction. Experimental and theoretical studies. J. Am. Chem. Soc. 2002, 124, 5091–5099. [Google Scholar]
  11. By, G.; Yit, W.; Pool, B.R.; White, J.M. Structural studies on cycloadducts of furan, 2-methoxyfuran, and 5-trimethylsilylcyclopentadiene with maleic anhydride and N-methylmaleimide. J. Org. Chem. 2008, 73, 151–156. [Google Scholar]

Share and Cite

MDPI and ACS Style

Goksu, G.; Ocal, N.; Kaufmann, D.E. Reductive Heck Reactions of N-Methyl-substituted Tricyclic Imides. Molecules 2010, 15, 1302-1308. https://doi.org/10.3390/molecules15031303

AMA Style

Goksu G, Ocal N, Kaufmann DE. Reductive Heck Reactions of N-Methyl-substituted Tricyclic Imides. Molecules. 2010; 15(3):1302-1308. https://doi.org/10.3390/molecules15031303

Chicago/Turabian Style

Goksu, Gokce, Nuket Ocal, and Dieter E. Kaufmann. 2010. "Reductive Heck Reactions of N-Methyl-substituted Tricyclic Imides" Molecules 15, no. 3: 1302-1308. https://doi.org/10.3390/molecules15031303

APA Style

Goksu, G., Ocal, N., & Kaufmann, D. E. (2010). Reductive Heck Reactions of N-Methyl-substituted Tricyclic Imides. Molecules, 15(3), 1302-1308. https://doi.org/10.3390/molecules15031303

Article Metrics

Back to TopTop