Platinum-Catalyzed Hydrative Cyclization of 1,6-Diynes for the Synthesis of 3,5-Substituted Conjugated Cyclohexenones
Abstract
:1. Introduction
2. Results and Discussion
Entry | Catalyst (mol%) | CH3SO3H (mol%) | Time (h) | Yield b (%) |
---|---|---|---|---|
1 | Pt(COD)Cl2 (5) | 50 | 3 | 75 |
2 | Pt(COD)Cl2 (5) | - | 3 | Trace |
3 | Pt(COD)Cl2 (2) | 50 | 3 | 21 |
4 | Pt(PPh3)Cl2 (2) | 50 | 4 | 12 |
5 | Pd(PiPr3)Cl2 (2) | 50 | 4 | NR |
6 | Pt(COD)Cl2 (2) | 50 | 4 | Nr |
3. Experimental
3.1. General
3.2. General procedure for the hydrative cyclization of diynes
4. Conclusions
Acknowledgements
- Sample Availability: Samples of the compounds are available from the authors.
References and Notes
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Zhang, C.; Qi, J.-F.; Cui, D.-M.; Wang, Q.; Wang, X.-L. Platinum-Catalyzed Hydrative Cyclization of 1,6-Diynes for the Synthesis of 3,5-Substituted Conjugated Cyclohexenones. Molecules 2010, 15, 5045-5052. https://doi.org/10.3390/molecules15075045
Zhang C, Qi J-F, Cui D-M, Wang Q, Wang X-L. Platinum-Catalyzed Hydrative Cyclization of 1,6-Diynes for the Synthesis of 3,5-Substituted Conjugated Cyclohexenones. Molecules. 2010; 15(7):5045-5052. https://doi.org/10.3390/molecules15075045
Chicago/Turabian StyleZhang, Chen, Jian-Feng Qi, Dong-Mei Cui, Qian Wang, and Xiu-Li Wang. 2010. "Platinum-Catalyzed Hydrative Cyclization of 1,6-Diynes for the Synthesis of 3,5-Substituted Conjugated Cyclohexenones" Molecules 15, no. 7: 5045-5052. https://doi.org/10.3390/molecules15075045