Synthesis, Singlet Oxygen Photogeneration and DNA Photocleavage of Porphyrins with Nitrogen Heterocycle Tails
Abstract
:1. Introduction
2. Results and Discussion
2.1. Photogeneration of 1O2
2.2. DNA photocleavage ability
3. Experimental
3.1. Materials and methods
3.2. Synthesis routes and procedures
3.2.1. Preparation of porphyrin 1
3.2.2. Preparation of porphyrin 2
3.2.3. Preparation of porphyrin 3
3.2.4. Preparation of porphyrin 4
3.2.5. Preparation of porphyrin 5
3.2.6. Preparation of porphyrin 6
3.2.7. Preparation of porphyrin 7
3.2.8. Preparation of porphyrin 8
3.3. Measurement of singlet oxygen production rate
3.4. DNA photocleavage assay
4. Conclusions
Acknowledgments
References and Notes
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Sample Availability: Samples of the porphyrin 1-8 and some intermediates are available from the authors. |
Porphyrin | M | X | Y | Ar |
---|---|---|---|---|
1 | 2H | O | CH | -Ph |
2 | Cu | O | CH | -Ph |
3 | 2H | O | N | |
4 | 2H | O | N | |
5 | Zn | O | N | -Ph |
6 | 2H | S | N | |
7 | 2H | S | N | |
8 | 2H | O | N |
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Zheng, Y.-M.; Wang, K.; Li, T.; Zhang, X.-L.; Li, Z.-Y. Synthesis, Singlet Oxygen Photogeneration and DNA Photocleavage of Porphyrins with Nitrogen Heterocycle Tails. Molecules 2011, 16, 3488-3498. https://doi.org/10.3390/molecules16053488
Zheng Y-M, Wang K, Li T, Zhang X-L, Li Z-Y. Synthesis, Singlet Oxygen Photogeneration and DNA Photocleavage of Porphyrins with Nitrogen Heterocycle Tails. Molecules. 2011; 16(5):3488-3498. https://doi.org/10.3390/molecules16053488
Chicago/Turabian StyleZheng, Yun-Man, Kai Wang, Tian Li, Xiu-Lan Zhang, and Zao-Yin Li. 2011. "Synthesis, Singlet Oxygen Photogeneration and DNA Photocleavage of Porphyrins with Nitrogen Heterocycle Tails" Molecules 16, no. 5: 3488-3498. https://doi.org/10.3390/molecules16053488