Unsymmetrical Mesoporphyrinic Complexes of Copper (II) and Zinc (II). Microwave-Assisted Synthesis, Spectral Characterization and Cytotoxicity Evaluation
Abstract
:1. Introduction
2. Results and Discussion
2.1. Infrared Spectra
Characteristic vibration | Wavenumber of the IR band (cm−1) | |
---|---|---|
Zn(II)TCMPOHp | Cu(II)TCMPOHp | |
νO-H | 3490 m | 3489 m |
νC-H | 2919 m | 2920 m |
νC-H from -O-CH3 | 2850 m | 2850 m |
νC=O | 1716 m | 1718 m |
νC-N | 1595 s | 1596 s |
νC=N | 1451 m | 1453 m |
νC-H pyrrole | 1390 m | 1384 w |
νC-O | 1158 m | 1157 m |
δC-H | 1029 m | 1032 w |
γC-C | 859 w | 857 w |
γC-Npyrrole | 790 m | 789 m |
2.2. Absorption and Fluorescence Spectra
Solvent | λmax (nm) [lgε (L mol−1 cm−1)] | ||
---|---|---|---|
Soret band | Q bands | ||
B(0,0) | Qy(0,0) | Qx(1,0) | |
5-(4-hydroxyphenyl)-10, 15, 20–tris-(4-carboxymethylphenyl)–21,23-Zn(II) porphine | |||
MeOH | 424.5 [5.732] | 557.7 [4.342] | 598.8 [4.049] |
EtOH | 426.0 [5.723] | 558.6 [4.310] | 599.7 [3.964] |
iso-PrOH | 426.7 [5.693] | 558.6 [4.283] | 600.0 [4.033] |
CH2Cl2 | 421.9 [5.659] | 549.1 [4.282] | 588.6 [3.602] |
DMF | 428.9 [5.713] | 560.7 [4.301] | 601.8 [4.033] |
DMSO | 431.5 [4.954] | 562.8 [4.246] | 603.6 [4.028] |
MeOH | 414.2 [5.532] | 538.6 [4.260] | - |
EtOH | 414.5 [5.571] | 538.9 [4.283] | - |
iso-PrOH | 414.8 [5.540] | 538.9 [4.259] | - |
CH2Cl2 | 417.1 [5.649] | 540.1 [4.356] | - |
DMF | 418.8 [5.555] | 541.3 [4.298] | 578.1(sh) |
DMSO | 422.9 [5.507] | 545.2 [4.203] | 587.4 [3.477] |
Solvent | λmax (nm) [If] (a.u.) | |
---|---|---|
Qx(0,0) | Qx(0,1) | |
MeOH | 605.2 [379.3] | 651.8 [63.2] |
EtOH | 606.8 [740.2] | 651.6 [118.0] |
iso-PrOH | 607.0 [776.8] | 653.1 [126.4] |
CH2Cl2 | 608.9 [585.5] | 653.5 [130.7] |
DMF | 609.7 [490.7] | 654.9 [81.5] |
DMSO | 610.9 [380.8] | 656.0 [49.9] |
2.3. Dark Cytotoxicity Tests
3. Experimental
3.1. Materials and Methods
3.2. Synthesis of 5-(4-hydroxyphenyl)-10, 15, 20–tris-(4-carboxymethylphenyl)–21, 23-Zn(II)-porphine (Zn(II)TCMPOHP)
3.3. Synthesis of 5-(4-hydroxyphenyl)-10, 15, 20–tris-(4-carboxymethylphenyl)–21, 23-Cu(II)-porphine (Cu(II)TCMPOHP)
4. Conclusions
Acknowledgements
References and Notes
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Boscencu, R. Unsymmetrical Mesoporphyrinic Complexes of Copper (II) and Zinc (II). Microwave-Assisted Synthesis, Spectral Characterization and Cytotoxicity Evaluation. Molecules 2011, 16, 5604-5617. https://doi.org/10.3390/molecules16075604
Boscencu R. Unsymmetrical Mesoporphyrinic Complexes of Copper (II) and Zinc (II). Microwave-Assisted Synthesis, Spectral Characterization and Cytotoxicity Evaluation. Molecules. 2011; 16(7):5604-5617. https://doi.org/10.3390/molecules16075604
Chicago/Turabian StyleBoscencu, Rica. 2011. "Unsymmetrical Mesoporphyrinic Complexes of Copper (II) and Zinc (II). Microwave-Assisted Synthesis, Spectral Characterization and Cytotoxicity Evaluation" Molecules 16, no. 7: 5604-5617. https://doi.org/10.3390/molecules16075604