Scutellaria baicalensis Alleviates Cantharidin-Induced Rat Hemorrhagic Cystitis through Inhibition of Cyclooxygenase-2 Overexpression
Abstract
:1. Introduction
2. Results
2.1. Cantharidin Induced T24 Cell Death
2.2. Cantharidin Induced Rat Hemorrhagic Cystitis Through Initiating Urinary Bladder Inflammation
2.3. Anti-Inflammatory Effects of Boiling-Water Extracts of S. baicalensis (SB-WE)
2.4. Uroprotective Effects of Boiling-Water Extracts of S. baicalensis (SB-WE)
2.5. Quality Control of the Boiling-Water Extract of Scutellaria baicalensis (SB-WE)
3. Discussion
4. Experimental
4.1. Chemicals
4.2. Cell Culture
4.3. Animals
4.4. Isolation of Cantharidin
4.5. Preparation and Quality Control of the Boiling Water Extract of S. baicalensis (SB-WE)
4.6. Cytotoxicity, PGE2 and NO Inhibitory Assay
4.7. Cantharidin Induced Hemorrhagic Cystitis in Wistar Rats
4.8. Statistical Analysis
5. Conclusions
Acknowledgments
References and Notes
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Huan, S.K.-H.; Wang, K.-T.; Yeh, S.-D.; Lee, C.-J.; Lin, L.-C.; Liu, D.-Z.; Wang, C.-C. Scutellaria baicalensis Alleviates Cantharidin-Induced Rat Hemorrhagic Cystitis through Inhibition of Cyclooxygenase-2 Overexpression. Molecules 2012, 17, 6277-6289. https://doi.org/10.3390/molecules17066277
Huan SK-H, Wang K-T, Yeh S-D, Lee C-J, Lin L-C, Liu D-Z, Wang C-C. Scutellaria baicalensis Alleviates Cantharidin-Induced Rat Hemorrhagic Cystitis through Inhibition of Cyclooxygenase-2 Overexpression. Molecules. 2012; 17(6):6277-6289. https://doi.org/10.3390/molecules17066277
Chicago/Turabian StyleHuan, Steven Kuan-Hua, Kun-Teng Wang, Shauh-Der Yeh, Chia-Jung Lee, Li-Chun Lin, Der-Zen Liu, and Ching-Chiung Wang. 2012. "Scutellaria baicalensis Alleviates Cantharidin-Induced Rat Hemorrhagic Cystitis through Inhibition of Cyclooxygenase-2 Overexpression" Molecules 17, no. 6: 6277-6289. https://doi.org/10.3390/molecules17066277