Antioxidant and Immunity Activities of Fufang Kushen Injection Liquid
Abstract
:1. Introduction
2. Results and Discussion
3. Experimental
3.1. Material
3.2. Animals and Grouping
3.3. Serum Ig Levels
3.4. IL-2, IL-4, IL-10, IL-6, TNF-α Levels
3.5. Measurement of Antioxidant Enzymes Activities
3.6. Statistical Analysis
4. Conclusions
Reference and Notes
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Sample Availability: Samples of the compounds are available from the authors. |
Group | IgA (mg/L) | IgM (mg/L) | IgG (mg/L) |
---|---|---|---|
NC | 147 ± 13 | 1683 ± 121 | 23156 ± 2085 |
MC | 58 ± 4 b | 1229 ± 112 b | 19352 ± 1593 b |
FFKSIL (2 mL/kg b.w.) | 86 ± 12 d | 1384 ± 141 c | 20461 ± 1837 |
FFKSIL (3 mL/kg b.w.) | 111 ± 14 d | 1433 ± 137 d | 21942 ± 1769 c |
FFKSIL (4 mL/kg b.w.) | 137 ± 14 d | 1575 ± 139 d | 22471 ± 2011 d |
Group | IL-2 (ng/mL) | IL-4 (ng/mL) | IL-10 (ng/mL) |
---|---|---|---|
NC | 6.07 ± 0.45 | 20.85 ± 1.83 | 91.48 ± 5.09 |
MC | 4.39 ± 0.28 b | 14.73 ± 1.11 b | 63.51 ± 3.17 b |
FFKSIL (2 mL/kg b.w.) | 4.98 ± 0.30 | 17.49 ± 1.32 d | 74.29 ± 3.52 c |
FFKSIL (3 mL/kg b.w.) | 5.73 ± 0.34 c | 18.88 ± 1.29 d | 82.91 ± 3.77 d |
FFKSIL (4 mL/kg b.w.) | 6.11 ± 0.29 d | 19.79 ± 1.42 d | 89.93 ± 4.29 d |
Group | IL-6 (ng/mL) | TNF-α (ng/mL) |
---|---|---|
NC | 70.54 ± 4.86 | 2.45 ± 0.18 |
MC | 89.69 ± 5.05 b | 3.87 ± 0.19 b |
FFKSIL (2 mL/kg b.w.) | 82.15 ± 4.97 c | 3.28 ± 0.22 |
FFKSIL (3 mL/kg b.w.) | 76.09 ± 4.82 c | 2.96 ± 0.21 d |
FFKSIL (4 mL/kg b.w.) | 72.13 ± 3.98 d | 2.57 ± 0.17 d |
Group | MDA | GSH | ||
---|---|---|---|---|
Serum | Gastric mucosa | Serum | Gastric mucosa | |
NC | 4.83 ± 0.29 | 3.79 ± 0.21 | 231.76 ± 18.32 | 121.04 ± 9.92 |
MC | 8.49 ± 0.53 b | 7.92 ± 0.53 b | 158.24 ± 12.14 b | 68.39 ± 4.28 b |
FFKSIL (2 mL/kg b.w.) | 7.03 ± 0.41 c | 5.82 ± 0.25 d | 188.26 ± 11.95 d | 89.37 ± 5.63 d |
FFKSIL (3 mL/kg b.w.) | 5.82 ± 0.22 d | 5.11 ± 0.31 d | 204.73 ± 13.29 d | 108.24 ± 7.04 d |
FFKSIL (4 mL/kg b.w.) | 4.71 ± 0.19 d | 4.27 ± 0.24 d | 223.18 ± 14.82 d | 119.32 ± 8.94 d |
Group | SOD | CAT | GSH-Px | |||
---|---|---|---|---|---|---|
Serum | Gastric mucosa | Serum | Gastric mucosa | Serum | Gastric mucosa | |
NC | 201.5 ± 18.38 | 174.3 ± 12.69 | 45.26 ± 2.68 | 38.29 ± 1.58 | 52.16 ± 3.52 | 47.73 ± 2.68 |
MC | 137.2 ± 11.32 b | 103.2 ± 8.49 b | 23.18 ± 1.65 b | 17.04 ± 1.21 b | 28.38 ± 1.69 b | 25.81 ± 2.01 b |
FFKSIL (2 mL/kg b.w.) | 170.5 ± 10.63 d | 139.5 ± 8.84 d | 33.29 ± 1.48 d | 24.72 ± 1.59 d | 39.91 ± 1.93 d | 31.54 ± 1.82 d |
FFKSIL (3 mL/kg b.w.) | 188.3 ± 13.29 d | 158.3 ± 10.42 d | 39.17 ± 1.77 d | 30.14 ± 1.99 d | 44.73 ± 2.64 d | 39.54 ± 1.95 d |
FFKSIL (4 mL/kg b.w.) | 197.2 ± 13.09 d | 177.2 ± 11.43 d | 48.32 ± 2.07 d | 39.12 ± 2.14 d | 49.81 ± 3.32 d | 49.03 ± 2.49 d |
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Zhou, S.-K.; Zhang, R.-L.; Xu, Y.-F.; Bi, T.-N. Antioxidant and Immunity Activities of Fufang Kushen Injection Liquid. Molecules 2012, 17, 6481-6490. https://doi.org/10.3390/molecules17066481
Zhou S-K, Zhang R-L, Xu Y-F, Bi T-N. Antioxidant and Immunity Activities of Fufang Kushen Injection Liquid. Molecules. 2012; 17(6):6481-6490. https://doi.org/10.3390/molecules17066481
Chicago/Turabian StyleZhou, Shen-Kang, Rui-Li Zhang, Yun-Feng Xu, and Tie-Nan Bi. 2012. "Antioxidant and Immunity Activities of Fufang Kushen Injection Liquid" Molecules 17, no. 6: 6481-6490. https://doi.org/10.3390/molecules17066481