The Role of Bioactive Compounds on the Promotion of Neurite Outgrowth
Abstract
:Abbreviations
Ntrk1: neurotrophic tyrosine kinase receptor type 1 | NGF: Nerve growth Factor, |
B-Raf: Serine/threonine-protein kinase | GTPP: Green tea polyphenol |
MEKK: mitogen-activated protein kinase kinase kinase | CREB: cAMP response element-binding |
MEK: mitogen-activated protein kinase kinase | Rap1: Ras-Proximate-1 |
ERK1/2: extracellular signal-regulated kinase | Ras: GTPasep21ras |
p38-MAPK: p38 mitogen-activated protein kinase | ROS: Reactive oxygen species |
1. Introduction
Main Biological Source | Compounds | Effective dose | Activity | Ref. |
---|---|---|---|---|
Panax ginseng | Ginsenoside Rb1 | 40 mg | Neuritogenesis in rats | [21] |
Panax ginseng | Ginsenoside Rg1 | 10 mM | Survival of dopaminergic neurons | [22] |
Curcuma longa | Curcumin | 10 & 20 μM/ 0.2 mg | Neurite outgrowth in PC12 cells/Neurogenesis in mouse | [23,24] |
Withania somnifera | Withanoside IV & VI | 1 μM | Axon & dendritic extension in rat cortical neurons | [4] |
Camellia sinensis | EGCG | 0.1–1 μM | Neurite outgrowth in PC12 cells | [25] |
Picrorhiza scrophulariiflora | Picroside I & II | 60 μM | Potentiating NGF induced neurite outgrowth in PC12D cells | [26] |
Propolis | Artepillin C | 10, 20 & 50 μM | Potentiating NGF induced neurite outgrowth | [16] |
Rehmannia glutinosa | Catalpol | 5, 15 & 50 mg | Increase in the number of mouse tyrosine hydroxylase positive cells | [27] |
Citrus depressa | Nobiletin | 100 μM | Neurite outgrowth in PC12 cells | [28] |
Sargassum macrocarpum | Sargaquinoic acid | 1.25–100 ng | Potentiating NGF induced neurite outgrowth in PC12D cells | [29] |
Tripterygium wilfordii | Tripchlorolide | 10−10 M | Neurite outgrowth & survival of dopaminergic neurons. | [30] |
Scutellaria baicalensis | Baicalein | 5 μg/ 50 & 200 mg | Neurite outgrowth in PC12cells/Increase & survival of rat TH-positive cells | [31] |
2. Natural Herbs and their Active Constituents with Neuritogenic Activity
2.1. Ginsenosides from ginseng
2.2. Curcumin from Curcuma longa
2.3. Withanosides from Withania somnifera
2.4. Green Tea Polyphenols from Camellia sinensis
2.5. Picrosides from Picrorhiza scrophulariiflora
3. Other Miscellaneous Compounds and Extracts from Natural Sources that Show Neuritogenic Activity
4. Conclusions
Acknowledgments
References
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More, S.V.; Koppula, S.; Kim, I.-S.; Kumar, H.; Kim, B.-W.; Choi, D.-K. The Role of Bioactive Compounds on the Promotion of Neurite Outgrowth. Molecules 2012, 17, 6728-6753. https://doi.org/10.3390/molecules17066728
More SV, Koppula S, Kim I-S, Kumar H, Kim B-W, Choi D-K. The Role of Bioactive Compounds on the Promotion of Neurite Outgrowth. Molecules. 2012; 17(6):6728-6753. https://doi.org/10.3390/molecules17066728
Chicago/Turabian StyleMore, Sandeep Vasant, Sushruta Koppula, In-Su Kim, Hemant Kumar, Byung-Wook Kim, and Dong-Kug Choi. 2012. "The Role of Bioactive Compounds on the Promotion of Neurite Outgrowth" Molecules 17, no. 6: 6728-6753. https://doi.org/10.3390/molecules17066728