Cytotoxic Podophyllotoxin Type-Lignans from the Steam Bark of Bursera fagaroides var. fagaroides
Abstract
:1. Introduction
2. Results and Discussion
Compound | KB | PC-3 | MCF-7 | HF-6 |
---|---|---|---|---|
HA | 9.6 × 10−2 ± 0.07 | 2.5 × 10−1 ± 0.03 | 6.6 ± 0.01 | 7.1 × 10−3 ± 0.1 |
F-1 | 6.0 × 10−3 ± 0.08 | 1.0 × 10−5 ± 0.006 | 8.8 × 10−1 ± 0.03 | 4.3 × 10−3 ± 0.04 |
F-2 | 1.3 × 10−1 ± 0.02 | 1.0 × 10−5 ± 0.004 | 8.2 × 10−1 ± 0.03 | 3.6 × 10−2 ± 0.02 |
F-1-1 | 3.94 × 10−1 ± 0.08 | 1.0 × 10−5 ± 0.1 | 8.1 ± 0.1 | 8.0 × 10−5 ± 0.03 |
F-1-2 | 3.5 × 10−1 ± 0.02 | 7.8 × 10−4 ± 0.06 | 1.3 ± 0.08 | 6.5 × 10−3 ± 0.01 |
F-2-1 | 1.9 × 10−1 ± 0.01 | 4.2 × 10−3 ± 0.02 | >20 | 3.5 × 10−2 ± 0.02 |
F-2-2 | 3.2 ± 0.01 | 2.0 ± 0.1 | >20 | 2.9 ± 0.05 |
F-2-3 | 1.0 × 10−2 ± 0.01 | 5.5 × 10−3 ± 0.01 | 2.5 × 10−7 ± 0.03 | 2.6 × 10−3 ± 0.001 |
1 | 1.91 × 10−6 ± 0.01 | 0.95 ± 0.005 | 1.04 × 10−5 ± 0.031 | 1.8 × 10−4 ± 0.01 |
2 | 0.189 ± 0.01 | 0.085 ± 0.005 | 0.798 ± 0.01 | 3.8 × 10−2 ± 0.01 |
3 | 1.0 × 10−5 ± 0.02 | 1.0 × 10−5 ± 0.004 | 1.02 × 10−4 ± 0.005 | 0.40 ± 0.01 |
4 | 0.4 ± 0.03 | 1.7 × 10−3 ± 0.01 | 0.4 ± 0.01 | 0.68 ± 0.01 |
5 | 1.5 ± 0.01 | 2.0 × 10−3 ± 0.003 | 1.25 ± 0.01 | 1.23 ± 0.01 |
6 | 2.89 ± 0.009 | 2.0 × 10−3 ± 0.005 | 3.68 ± 0.08 | 2.89 ± 0.006 |
7 | 1.03 ± 0.01 | 5.0 × 10−3 ± 0.005 | >4 | 2.41 ± 0.004 |
Camptothecin | 1.58 × 10−3 ± 0.01 | 0.96 ± 0.006 | 1.28 × 10−4 ± 0.01 | 5.5 × 10−6 ± 0.01 |
Podophyllotoxin | 8.7 × 10−5 ± 0.003 | 0.85 ± 0.009 | 9.9 × 10−5 ± 0.005 | 7.6 × 10−3 ± 0.05 |
Etoposide | 25 × 10−3 ± 0.002 | 5.6 × 10−3 ± 0.0005 | 0.54 ± 0.009 | 0.091 ± 0.02 |
3. Experimental
3.1. General
3.2. Plant Material
3.3. Extraction and Isolation
3.4. Spectral Data
3.5. Cytotoxicity Assay
3.6. Antitumor Activity
3.7. Statistical Analysis
4. Conclusions
Acknowledgments
References
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Rojas-Sepúlveda, A.M.; Mendieta-Serrano, M.; Mojica, M.Y.A.; Salas-Vidal, E.; Marquina, S.; Villarreal, M.L.; Puebla, A.M.; Delgado, J.I.; Alvarez, L. Cytotoxic Podophyllotoxin Type-Lignans from the Steam Bark of Bursera fagaroides var. fagaroides. Molecules 2012, 17, 9506-9519. https://doi.org/10.3390/molecules17089506
Rojas-Sepúlveda AM, Mendieta-Serrano M, Mojica MYA, Salas-Vidal E, Marquina S, Villarreal ML, Puebla AM, Delgado JI, Alvarez L. Cytotoxic Podophyllotoxin Type-Lignans from the Steam Bark of Bursera fagaroides var. fagaroides. Molecules. 2012; 17(8):9506-9519. https://doi.org/10.3390/molecules17089506
Chicago/Turabian StyleRojas-Sepúlveda, Andrés M., Mario Mendieta-Serrano, Mayra Y. Antúnez Mojica, Enrique Salas-Vidal, Silvia Marquina, María Luisa Villarreal, Ana María Puebla, Jorge I. Delgado, and Laura Alvarez. 2012. "Cytotoxic Podophyllotoxin Type-Lignans from the Steam Bark of Bursera fagaroides var. fagaroides" Molecules 17, no. 8: 9506-9519. https://doi.org/10.3390/molecules17089506