Antitrypanosomal Alkaloids from the Marine Bacterium Bacillus pumilus
Abstract
:1. Introduction
2. Results and Discussion
2.1. Collection and Identification of Biological Material
2.2. Extraction, Isolation and Structural Elucidation of Compounds
2.3. Antiparasitic Activity
Compounds | L. donovani | P. falciparum | T. cruzia |
---|---|---|---|
Cyclo-(L-Leu-L-Pro) (1) | I | I | I |
3-Hydroxyacetylindole (2) | I | I | 20.6 |
N-acetyl-β-oxotryptamine (3) | I | I | 19.4 |
Cyclo-(L-Phe-L-Pro) (4) | I | I | I |
3-Formylindole (5) | I | I | 26.9 |
Nifurtimox | 1.6 |
3. Experimental
3.1. General Procedures
3.2. Biological Material Collection and Identification
3.3. Fermentation and Extraction
3.4. Isolation of Alkaloids
3.5. Spectral Data
3.6. In Vitro Biological Activity
3.6.1. Plasmodium falciparum Bioassay
3.6.2. Leishmania donovani Bioassay
3.6.3. Trypanosoma cruzi Bioassay
3.6.4. Cytotoxicity Bioassay
4. Conclusions
Acknowledgments
References
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Martínez-Luis, S.; Gómez, J.F.; Spadafora, C.; Guzmán, H.M.; Gutiérrez, M. Antitrypanosomal Alkaloids from the Marine Bacterium Bacillus pumilus. Molecules 2012, 17, 11146-11155. https://doi.org/10.3390/molecules170911146
Martínez-Luis S, Gómez JF, Spadafora C, Guzmán HM, Gutiérrez M. Antitrypanosomal Alkaloids from the Marine Bacterium Bacillus pumilus. Molecules. 2012; 17(9):11146-11155. https://doi.org/10.3390/molecules170911146
Chicago/Turabian StyleMartínez-Luis, Sergio, José Félix Gómez, Carmenza Spadafora, Héctor M. Guzmán, and Marcelino Gutiérrez. 2012. "Antitrypanosomal Alkaloids from the Marine Bacterium Bacillus pumilus" Molecules 17, no. 9: 11146-11155. https://doi.org/10.3390/molecules170911146