Synthesis of Dimethyl Aryl Acylsulfonium Bromides from Aryl Methyl Ketones in a DMSO-HBr System
Abstract
:1. Introduction
2. Results and Discussion
Entry | Aryl Acetone | Product | Yield (%) |
---|---|---|---|
a | | | 69 |
b | | | 57 |
c | | | 71 |
d | | | 62 |
e | | | 75 |
f | | | 55 |
g | | | 57 |
h | | | 48 |
Entry | Molar Ratio Methyl Ketone/HBr | Time (h) | Temp. (°C) | Yield (%)b |
---|---|---|---|---|
1 | 1:3 | 6 | 40 | 41 |
2 | 1:3 | 10 | 40 | 69 |
3 | 1:3 | 12 | 40 | 56 |
4 | 1:3 | 10 | 55 | 45 |
5 | 1:1 | 12 | 40 | 12 |
6 | 1:5 | 6 | 40 | 61 |
3. Experimental
3.1. General
3.2. General Procedure for the Synthesis of Sulfonium Salts 3a–h
4. Conclusions
Acknowledgments
Conflicts of Interest
References
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Cao, Z.; Shi, D.; Qu, Y.; Tao, C.; Liu, W.; Yao, G. Synthesis of Dimethyl Aryl Acylsulfonium Bromides from Aryl Methyl Ketones in a DMSO-HBr System. Molecules 2013, 18, 15717-15723. https://doi.org/10.3390/molecules181215717
Cao Z, Shi D, Qu Y, Tao C, Liu W, Yao G. Synthesis of Dimethyl Aryl Acylsulfonium Bromides from Aryl Methyl Ketones in a DMSO-HBr System. Molecules. 2013; 18(12):15717-15723. https://doi.org/10.3390/molecules181215717
Chicago/Turabian StyleCao, Zhiling, Dahua Shi, Yingying Qu, Chuanzhou Tao, Weiwei Liu, and Guowei Yao. 2013. "Synthesis of Dimethyl Aryl Acylsulfonium Bromides from Aryl Methyl Ketones in a DMSO-HBr System" Molecules 18, no. 12: 15717-15723. https://doi.org/10.3390/molecules181215717