Synthesis and Structure-Activity Relationships of Novel Amino/Nitro Substituted 3-Arylcoumarins as Antibacterial Agents
Abstract
:1. Introduction
2. Results and Discussion
Compounds | Method A (mm) | Method B (µg/mL) | ||
---|---|---|---|---|
S. aureus | E. coli | S. aureus | E. coli | |
1 | 19 | NA | 128 | - |
2 | 25 | NA | 64 | - |
3 | 22 | NA | 32 | - |
4 | 22 | NA | 32 | - |
5 | 25 | NA | 64 | - |
6 | 32 | NA | 8 | - |
7 | 14 | NA | 256 | - |
8 | NA | NA | >512 | - |
9 | NA | NA | >512 | - |
10 | NA | NA | >512 | - |
11 | 18 | NA | 128 | - |
Oxolinic acid | 26 | 31 | 2 | <1 |
Ampicillin | 32 | 23 | 2 | 8 |
Compounds | LogP |
---|---|
1 | 3,631 |
2 | 3,729 |
3 | 4,120 |
4 | 3,607 |
5 | 3,705 |
6 | 4,096 |
7 | 4,457 |
8 | 3,729 |
9 | 3,705 |
10 | 4,120 |
11 | 1,841 |
3. Experimental
3.1. Chemistry
Procedure for the Preparation of 3-(3′-Aminophenyl)-6-Aminocoumarin (11)
4. Conclusions
Acknowledgments
References
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Matos, M.J.; Vazquez-Rodriguez, S.; Santana, L.; Uriarte, E.; Fuentes-Edfuf, C.; Santos, Y.; Muñoz-Crego, A. Synthesis and Structure-Activity Relationships of Novel Amino/Nitro Substituted 3-Arylcoumarins as Antibacterial Agents. Molecules 2013, 18, 1394-1404. https://doi.org/10.3390/molecules18021394
Matos MJ, Vazquez-Rodriguez S, Santana L, Uriarte E, Fuentes-Edfuf C, Santos Y, Muñoz-Crego A. Synthesis and Structure-Activity Relationships of Novel Amino/Nitro Substituted 3-Arylcoumarins as Antibacterial Agents. Molecules. 2013; 18(2):1394-1404. https://doi.org/10.3390/molecules18021394
Chicago/Turabian StyleMatos, Maria J., Saleta Vazquez-Rodriguez, Lourdes Santana, Eugenio Uriarte, Cristina Fuentes-Edfuf, Ysabel Santos, and Angeles Muñoz-Crego. 2013. "Synthesis and Structure-Activity Relationships of Novel Amino/Nitro Substituted 3-Arylcoumarins as Antibacterial Agents" Molecules 18, no. 2: 1394-1404. https://doi.org/10.3390/molecules18021394