N6-Benzyladenosine Derivatives as Novel N-Donor Ligands of Platinum(II) Dichlorido Complexes
Abstract
:1. Introduction
2. Results and Discussion
2.1. Characterizations and General Properties of the Complexes
1H-NMR | 13C-NMR | 15N-NMR | 195Pt | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
C2H | N6H | C8H | C2 | C4 | C5 | C6 | C8 | N1 | N3 | N6 | N7 | N9 | ||
1 | −0.09 | 0.82 | 0.84 | 1.35 | −0.82 | −4.07 | −2.36 | 2.76 | 3.82 | 1.17 | 8.47 | −105.03 | 5.60 | −2077.10 |
2 | 0.18 | 0.52 | 0.84 | 1.41 | −0.85 | −4.03 | −2.28 | 2.92 | 5.03 | 2.00 | 6.67 | −105.02 | 6.17 | −2072.08 |
3 | 0.17 | 0.60 | 0.88 | 1.37 | −0.80 | −4.01 | −2.27 | 2.96 | 3.24 | 0.82 | 6.57 | −106.00 | 4.96 | −2074.81 |
4 | 0.19 | 0.51 | 0.92 | 1.27 | −0.98 | −4.14 | −2.37 | 2.88 | 3.61 | 1.55 | 4.96 | −106.69 | 5.45 | −2071.38 |
5 | 0.12 | 0.69 | 0.72 | 1.61 | −0.82 | −3.90 | −1.91 | 2.62 | 7.11 | 0.70 | 5.05 | −105.70 | 5.09 | −2076.80 |
6 | 0.18 | 0.59 | 0.84 | 1.31 | −0.88 | −4.07 | −2.29 | 2.93 | 3.85 | 1.91 | 5.51 | −105.78 | 6.21 | −2074.68 |
7 | 0.15 | 0.75 | 0.69 | 1.49 | −0.92 | −3.97 | −4.06 | 2.73 | 6.98 | 0.34 | 5.82 | −106.22 | 4.78 | −2078.30 |
8 | 0.19 | 0.52 | 0.90 | 1.31 | −0.93 | −4.13 | −2.29 | 2.90 | 3.67 | 0.33 | 6.52 | −105.37 | 6.32 | −2071.68 |
9 | 0.19 | 0.55 | 0.83 | 1.34 | −0.88 | −4.07 | −2.32 | 2.89 | 4.46 | 1.76 | 4.89 | −106.10 | 5.86 | −2073.15 |
10 | − | 0.26 | 0.83 | −0.53 | −1.19 | −3.76 | −0.66 | 3.03 | 3.13 | −0.31 | 6.15 | −106.52 | 5.02 | −2084.94 |
11 | − | 0.60 | 0.83 | 1.30 | −1.01 | −3.68 | −2.18 | 3.14 | 3.45 | 0.26 | 3.30 | −106.24 | 5.00 | −2083.47 |
12 | − | 0.81 | 0.69 | 1.34 | −0.90 | −3.66 | −2.31 | 3.04 | 3.92 | 0.16 | 4.90 | −105.72 | 5.03 | −2088.28 |
13 | − | 0.85 | 0.78 | 0.12 | −0.83 | −3.27 | −0.60 | 1.81 | 4.89 | – | 4.96 | −105.76 | 5.33 | −2091.62 |
2.2. In Vitro Cytotoxic Activity
2.3. Interactions of the Selected Complexes 7 and 12 with l-Methionine, Evaluated by Mass Spectrometry
3. Experimental
3.1. Materials
3.2. Methods
3.3. Synthesis
3.4. In Vitro Cytotoxic Activity Testing
3.5. Interactions of the Selected Complexes 7 and 12 with L-Methionine, Evaluated by Mass Spectrometry
4. Conclusions
Supplementary Materials
Acknowledgments
Conflicts of Interest
References
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Štarha, P.; Popa, I.; Trávníček, Z.; Vančo, J. N6-Benzyladenosine Derivatives as Novel N-Donor Ligands of Platinum(II) Dichlorido Complexes. Molecules 2013, 18, 6990-7003. https://doi.org/10.3390/molecules18066990
Štarha P, Popa I, Trávníček Z, Vančo J. N6-Benzyladenosine Derivatives as Novel N-Donor Ligands of Platinum(II) Dichlorido Complexes. Molecules. 2013; 18(6):6990-7003. https://doi.org/10.3390/molecules18066990
Chicago/Turabian StyleŠtarha, Pavel, Igor Popa, Zdeněk Trávníček, and Ján Vančo. 2013. "N6-Benzyladenosine Derivatives as Novel N-Donor Ligands of Platinum(II) Dichlorido Complexes" Molecules 18, no. 6: 6990-7003. https://doi.org/10.3390/molecules18066990