Next Article in Journal
Synthesis, Evaluation of Antioxidant Activity and Crystal Structure of 2,4-Dimethylbenzoylhydrazones
Next Article in Special Issue
Repetitive Two-Step Method for o,o,p- and o,p-Oligophenylene Synthesis through Pd-Catalyzed Cross-Coupling of Hydroxyterphenylboronic Acid
Previous Article in Journal
Italian Chemists’ Contributions to Named Reactions in Organic Synthesis: An Historical Perspective
Previous Article in Special Issue
Palladium-Catalyzed Synthesis of Natural and Unnatural 2-, 5-, and 7-Oxygenated Carbazole Alkaloids from N-Arylcyclohexane Enaminones
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 18
Issue 9
10.3390/molecules180910901
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

A Recyclable Palladium-Catalyzed Synthesis of 2-Methylene-2,3-Dihydrobenzofuran-3-ols by Cycloisomerization of 2-(1-Hydroxyprop-2-ynyl)phenols in Ionic Liquids

by
Raffaella Mancuso
* and
Bartolo Gabriele
*
Dipartimento di Chimica e Tecnologie Chimiche, Università della Calabria, Ponte Pietro Bucci 12/C, Arcavacata di Rende (CS) 87036, Italy
*
Authors to whom correspondence should be addressed.
Molecules 2013, 18(9), 10901-10911; https://doi.org/10.3390/molecules180910901
Submission received: 29 July 2013 / Revised: 21 August 2013 / Accepted: 2 September 2013 / Published: 4 September 2013
(This article belongs to the Special Issue Palladium Catalysts)
Browse Figures
Versions Notes

Abstract

:
A recyclable palladium-catalyzed synthesis of 2-methylene-2,3-dihydrobenzofuran-3-ols 2 by heterocyclization of 2-(1-hydroxyprop-2-ynyl)phenols 1 in an ionic liquid medium (BmimBF4) is presented. The process takes place under relatively mild conditions (100 °C, 5 h) in the presence of catalytic amounts (2 mol %) of PdI2 in conjunction with KI (5 equiv with respect to PdI2) and an organic base, such as morpholine (1 equiv with respect to 1), to give 2 in high yields (70%–86%). The PdI2-KI catalytic system could be recycled up to six times without appreciable loss of activity. Moreover, products 2 could be easily converted in a one-pot fashion into 2-hydroxymethylbenzofurans 3 (52%–71%, based on 1) and 2-methoxymethylbenzofurans 4 (52%–80%, based on 1) by acid-catalyzed allylic isomerization or allylic nucleophilic substitution.

Graphical Abstract

1. Introduction

Metal-catalyzed heterocyclization reactions are a powerful methodology for the direct synthesis of substituted heterocyclic derivatives starting from readily available substrates [1,2,3,4,5,6,7,8,9,10,11]. The process occurs through the activation of an unsaturated bond by coordination to the metal center, followed by endo or exo intramolecular attack by the nucleophilic group (YH) and protonolysis or vice versa (Scheme 1—the case of a functionalized alkyne is shown). In particular, we have reported several metal-catalyzed heterocyclizations of acetylenes, bearing a nucleophilic group in a suitable position for cyclization, which have proved valuable for the preparation of a variety of important heterocycles, including furans, pyrroles, thiophenes, and benzothiophenes [12,13,14,15,16,17,18,19,20].
Molecules 18 10901 g001 550
Scheme 1. Metal-catalyzed heterocyclization of acetylenes bearing a suitably placed nucleophilic group leading to heterocycles through activation of the triple bond by the metal species followed by intramolecular nucleophilic attack and protonolysis.
Scheme 1. Metal-catalyzed heterocyclization of acetylenes bearing a suitably placed nucleophilic group leading to heterocycles through activation of the triple bond by the metal species followed by intramolecular nucleophilic attack and protonolysis.
Molecules 18 10901 g001
Recently, we have reported a novel approach to the synthesis of 2-methylene-2,3-dihydrobenzofuran-3-ols 2 by Pd-catalyzed heterocyclization of 2-(1-hydroxyprop-2-ynyl)phenols 1, carried out in MeOH in the presence of PdX2 as catalyst in conjunction with KX (X = Cl, I) and morpholine as the base, necessary for substrate deprotonation [18]. Either 5-exo-dig intramolecular attack to coordinated triple bond (path a) or triple bond insertion into the Pd-O bond of a phenoxypalladium intermediate (path b) may take place, according to Scheme 2 [18].
Molecules 18 10901 g002 550
Scheme 2. Formation of 2-methylene-2,3-dihydrobenzofuran-3-ols 2 by Pd-catalyzed heterocyclization of 2-(1-hydroxyprop-2-ynyl)phenols 1 in the presence of morpholine as the base (B) in MeOH as the solvent [18].
Scheme 2. Formation of 2-methylene-2,3-dihydrobenzofuran-3-ols 2 by Pd-catalyzed heterocyclization of 2-(1-hydroxyprop-2-ynyl)phenols 1 in the presence of morpholine as the base (B) in MeOH as the solvent [18].
Molecules 18 10901 g002
We have now found that this process can also be conveniently performed in an ionic liquid (IL), such as 3-butyl-1-methyl-imidazolium tetrafluoroborate (BmimBF4) as the solvent, and that by using this unconventional medium [21,22,23,24,25,26,27,28,29,30,31], it is possible to recycle the catalytic system several times without appreciable loss of activity (Scheme 3). We have also found that, in BmimBF4, methylenedihydrobenzofuranols 2 can be readily converted into 2-hydroxymethylbenzofurans 3 or 2-methoxymethylbenzofurans 4 by acid-catalyzed allylic isomerization or allylic nucleophilic substitution in a one-pot fashion. The recyclability of metal catalysts has acquired an increasing importance in the modern organic synthesis, as testified by recent publications in this field [32,33,34,35,36,37,38,39,40,41].
Molecules 18 10901 g003 550
Scheme 3. Recyclable Pd-catalyzed synthesis of 2-methylene-2,3-dihydrobenzofuran-3-ols 2 in BmimBF4, and their one-pot conversion into 2-hydroxymethylbenzofurans 3 or 2-methoxymethylbenzofurans 4.
Scheme 3. Recyclable Pd-catalyzed synthesis of 2-methylene-2,3-dihydrobenzofuran-3-ols 2 in BmimBF4, and their one-pot conversion into 2-hydroxymethylbenzofurans 3 or 2-methoxymethylbenzofurans 4.
Molecules 18 10901 g003

2. Results and Discussion

2-(1-Hydroxy-1-phenylprop-2-ynyl)phenol (1a) was chosen as the model substrate for testing the reactivity of 2-(1-hydroxyprop-2-ynyl)phenols in ionic liquids. The reaction of 1a, carried out in BmimBF4 as the solvent at 70 °C for 5 h, in the presence of 2 mol % of PdI2 in conjunction with KI (5 equiv with respect to PdI2) and morpholine (1 equiv. with respect to 1a), led to the formation of 2-methylene-3-phenyl-2,3-dihydrobenzofuran-3-ol (2a) in 60% isolated yield at 80% substrate conversion (Table 1, entry 1). This initial result clearly confirmed the feasibility of the process in an ionic liquid as the reaction medium. Substrate conversion reached 100% either after 8 h at the same temperature (with a 2a yield of 82%, Table 1, entry 2) or after 5 h at 100 °C (with a 2a yield of 86%, Table 1, entry 3). The reaction also worked well with 1 mol % of catalyst, as shown in Table 1, entry 4 (2a yield was 80%). On the other hand, the use of 4 mol % of KI or the use of PdCl2/KCl instead of PdI2/KI led to inferior results (Table 1, entries 5 and 6, respectively). Lower yields of 2a were also obtained working in other ILs, such as BmimCl, BmimPF6, BmimN(CN)2, or BmimOTf (Table 1, entries 7–10).
The next experiments were aimed at verifying the recyclability of the catalyst-IL system and at generalizing the process to other variously substituted substrates, using BmimBF4 as the reaction medium at 100 °C for 5 h. Regarding the recycling experiments, the reaction crude deriving from the reaction carried out under the same conditions as those reported in Table 1, entry 3, was extracted several times with diethyl ether, to isolate the product, while the residue (containing the catalyst dissolved in the IL), after drying under vacuum, was used again by adding to it fresh substrate 1a and morpholine (1:1 ratio). After stirring at 100 °C for 5 h, 2a was obtained again, with practically the same yield as the parent reaction (85%, Table 2, entry 1, run 2). The recycling procedure was then repeated up to 5 times, without any appreciable loss of catalytic activity (Table 2, entry 1, runs 3–7).
Table
Table 1. Iodocyclodehydration of 4-mercapto-3-methyl-1-phenylpent-1-yn-3-ol (1a) to 3-iodo-4,5-dimethyl-2-phenylthiophene (2a) under different conditions a. Molecules 18 10901 i001
Table 1. Iodocyclodehydration of 4-mercapto-3-methyl-1-phenylpent-1-yn-3-ol (1a) to 3-iodo-4,5-dimethyl-2-phenylthiophene (2a) under different conditions a. Molecules 18 10901 i001
EntryIonic LiquidT (°C)Conversion of 1a b (%)Yield of 2a c (%)
1BmimBF4708060
2 dBmimBF47010082
3BmimBF410010086
4 eBmimBF410010080
5 fBmimBF410010063
6 gBmimBF410010065
7BmimCl10010051
8BmimPF610010058
9BmimN(CN)210010063
10BmimOTf1006023
a Unless otherwise noted, all cycloisomerization reactions were carried out for 5 h under nitrogen with a substrate concentration of 0.25 mmol of 1a per mL of ionic liquid. The morpholine:1a:KI:PdI2 molar ratio was 50:50:5:1. The formation of a complex mixture of products accounted for the difference between substrate conversion and the yield of 2a. b Based on isolated unreacted 1a. c Isolated yield based on starting 1a. d The reaction time was 8 h. e The reaction was carried out with 1 mol % of PdI2. f The reaction was carried with 4 mol % of KI. g The reaction was carried with PdCl2+5KCl rather than with PdI2 + 5KI.
Table
Table 2. Recyclable Synthesis of 2-methylene-2,3-dihydrobenzofuran-3-ols (2) by PdI2/KI-catalyzed cycloisomerization of 2-(1-hydroxyprop-2-ynyl)phenols (1) in BmimBF4 a. Molecules 18 10901 i002
Table 2. Recyclable Synthesis of 2-methylene-2,3-dihydrobenzofuran-3-ols (2) by PdI2/KI-catalyzed cycloisomerization of 2-(1-hydroxyprop-2-ynyl)phenols (1) in BmimBF4 a. Molecules 18 10901 i002
Entry12Yield of 2 (%) b
Run 1 cRun 2 cRun 3 cRun 4 cRun 5 cRun 6 cRun 7 c
1 Molecules 18 10901 i003 Molecules 18 10901 i00486858786858687
2 Molecules 18 10901 i005 Molecules 18 10901 i00684868275727372
3 Molecules 18 10901 i007 Molecules 18 10901 i00870717168706970
4 Molecules 18 10901 i009 Molecules 18 10901 i01078807880818180
5 Molecules 18 10901 i011 Molecules 18 10901 i01280817980788179
6 Molecules 18 10901 i013 Molecules 18 10901 i01475777677757678
7 Molecules 18 10901 i015 Molecules 18 10901 i01676767775787477
a All reactions were carried out at 100 °C in BmimBF4 under nitrogen for 5 h with a substrate concentration of 0.25 mmol of 1 per mL of ionic liquid. The morpholine:1:KI:PdI2 molar ratio was 50:50:5:1. Conversion of 1 was quantitative in all cases. b Isolated yield based on starting 1. c Run 1 corresponds to the 1st experiment, the next runs to recycles. See text for details.
The method was then extended to other 2-(1-hydroxyprop-2-ynyl)phenols 1b–g, bearing different (either electron-withdrawing or electron-donating) substituents on the aromatic ring and at the benzylic position. As can be seen from the results shown in Table 2, entries 2–7, good yields of the corresponding methylenedihydrobenzofurans 2b–g were consistently obtained. We also checked the catalyst-solvent recyclability in all cases, still with satisfactory results, products being obtained in comparable yields with respect to the parent reactions (Table 2, entries 2–7).
2-Methylene-2,3-dihydrobenzofuran-3-ols 2 are known to be useful precursors for the preparation of functionalized benzofurans [18,42]. In particular, we previously reported that they can easily undergo acid-catalyzed allylic isomerization to give 2-hydroxymethylbenzofurans 3 or acid-catalyzed allylic nucleophilic substitution to give 2-methoxymethylbenzofurans 4 [18]. We have now found that it is possible to directly obtain either benzofurans 3 or 4 in a one-pot fashion by Pd-catalyzed cycloisomerization of 1 in BmimBF4, followed by acid catalyzed allylic isomerization or nucleophilic substitution, without the need for isolating compounds 2. Thus, the reaction mixture resulting from the cycloisomerization process was allowed to cool down to room temperature, and then H2SO4 in water or in MeOH was added. After 3–18 h at 100 °C, the corresponding benzofuran derivatives 3 and 4 were obtained in high yields (Table 3). Clearly, no IL recyclability was possible for this one-pot transformation.
Table
Table 3. Synthesis of 2-hydroxymethylbenzofurans 3 and 2-methoxymethylbenzofurans 4 by one-pot PdI2/KI-catalyzed cycloisomerization of 2-(1-hydroxyprop-2-ynyl)phenols ‒ allylic isomerization or allylic nucleophilic substitution a. Molecules 18 10901 i017
Table 3. Synthesis of 2-hydroxymethylbenzofurans 3 and 2-methoxymethylbenzofurans 4 by one-pot PdI2/KI-catalyzed cycloisomerization of 2-(1-hydroxyprop-2-ynyl)phenols ‒ allylic isomerization or allylic nucleophilic substitution a. Molecules 18 10901 i017
Entry1Rt (h)3 or 4Yield of 3 or 4 b (%)
1 Molecules 18 10901 i003H3 Molecules 18 10901 i01865
2 Molecules 18 10901 i005H3 Molecules 18 10901 i01955
3 Molecules 18 10901 i007H3 Molecules 18 10901 i02054
4 Molecules 18 10901 i021H3 Molecules 18 10901 i02271
5 Molecules 18 10901 i023H3 Molecules 18 10901 i02456
6 Molecules 18 10901 i025H3 Molecules 18 10901 i02652
7 Molecules 18 10901 i015H3 Molecules 18 10901 i02754
81aMe18 Molecules 18 10901 i02880
91bMe18 Molecules 18 10901 i02965
101cMe18 Molecules 18 10901 i03052
111dMe15 Molecules 18 10901 i03170
121eMe18 Molecules 18 10901 i03252
131fMe18 Molecules 18 10901 i03355
141gMe18 Molecules 18 10901 i03460
a All cycloisomerization reactions were carried out at 100 °C in BmimBF4 under nitrogen for 5 h with a substrate concentration of 0.25 mmol of 1 per mL of ionic liquid. The morpholine:1:KI:PdI2 molar ratio was 50:50:5:1. The allylic isomerization or allylic nucleophilic substitution was carried out in a one-pot fashion by adding H2SO4 in water or in MeOH (R = H or Me, respectively; 0.75 M) to the reaction crude deriving from the cycloisomerization reaction, and allowing the resulting mixture to stir a 100 °C for the required time. Conversion of 1 was quantitative in all cases. b Isolated yield based on starting 1.

3. Experimental

3.1. General

Melting points were taken on a Reichert Thermovar apparatus and are uncorrected. 1H-NMR and 13C-NMR spectra were recorded at 25 °C in CDCl3 solutions with a Bruker DPX Avance 300 spectrometer operating at 300 MHz and 75 MHz, respectively, with Me4Si as internal standard. Chemical shifts (δ) and coupling constants (J) are given in ppm and in Hz, respectively. IR spectra were taken with a JASCO FT-IR 4200 spectrometer. Mass spectra were obtained using a Shimadzu QP-2010 GC-MS apparatus at 70 eV ionization voltage. Microanalyses were carried out with a Carlo Erba Elemental Analyzer Mod. 1106. All reactions were analyzed by TLC on silica gel 60 F254 (Merck) or on neutral alumina (Merck) and by GLC using a Shimadzu GC-2010 gas chromatograph and capillary columns with polymethylsilicone + 5% polyphenylsilicone as the stationary phase (HP-5). Column chromatography was performed on silica gel 60 (Merck, 70–230 mesh) or neutral alumina 90 (Merck, 70–230 mesh). Evaporation refers to the removal of solvent under reduced pressure.

3.2. Preparation of Substrates

Starting 2-(1-hydroxyprop-2-ynyl)phenols 1 were prepared and characterized as already described [43].

3.3. Preparation of Ionic Liquids

Ionic liquid BmimOTf [44] was prepared according to a literature procedure. All other ionic liquids were prepared as previously described [17].

3.4. General Procedure for the PdI2/KI-Catalyzed Cycloisomerization of 2-(1-Hydroxyprop-2-ynyl)phenols 1 to Give 2-Methylene-2,3-Dihydrobenzofuran-3-ols 2

To a Schlenk flask containing PdI2 (1.8 mg, 5.0 × 10−3 mmol), KI (4.2 mg, 2.5 × 10−2 mmol) and BmimBF4 (1 mL) was added, under nitrogen, a solution of 1 (0.25 mmol) in Et2O (1.5 mL). The diethyl ether was eliminated under vacuum, and then morpholine (22.0 mg, 0.25 mmol) was added under nitrogen. The resulting mixture was allowed to stir under nitrogen at 100 °C for 5 h. After cooling, the mixture was extracted with Et2O (6 × 2 mL), to separate the product, while the residue, still containing the catalysts dissolved in the IL, was used as such for the recycling experiments (see below). The collected ethereal phases were concentrated, and products 2 were purified by column chromatography on silica gel using hexane-AcOEt from 95:5 to 9:1 as the eluent. The yields obtained in each experiments are reported in Table 2.
Recycling Procedure. To the residue obtained as described above, still containing the catalyst dissolved in the ionic liquid, was added under nitrogen a solution of 1 (0.25 mmol) in Et2O (1.5 mL). Diethyl ether was removed under vacuum, morpholine (22.0 mg, 0.25 mmol) was added, and then the same procedure described above was followed.

3.5. General Procedure for the One-Pot Synthesis of 2-Hydroxymethylbenzofurans 3 and 2-Methoxy- methylbenzofurans 4 Starting From 2-(1-Hydroxyprop-2-ynyl)phenols 1

To a Schlenk flask containing PdI2 (1.8 mg, 5.0 × 10−3 mmol), KI (4.2 mg, 2.5 × 10−2 mmol) and BmimBF4 (1 mL) was added, under nitrogen, a solution of 1 (0.25 mmol) in Et2O (1.5 mL). The diethyl ether was eliminated under vacuum, and then morpholine (22.0 mg, 0.25 mmol) was added under nitrogen. The resulting mixture was allowed to stir under nitrogen at 100 °C for 5 h. After cooling, a solution of H2SO4 in ROH (R = H or Me, 0.75 M) (670 μL, 0.5 mmol) was added under nitrogen (together with 100 μL of MeOH when R = Me), and the mixture was allowed to stir at 100 °C for 3 h (R = H) or overnight (18 h, R = Me). After cooling, the mixture was extracted with Et2O (6 × 2 mL). The collected ethereal phases were concentrated, and products 3 (R = H) and 4 (R = Me) were purified by column chromatography on silica gel using hexane-AcOEt from 95:5 to 9:1 as the eluent. The yields obtained in each experiment are reported in Table 3.

3.6. Characterization of Products

All products 2, 3, and 4 were characterized by comparison with the characterization data already reported by us [18].

4. Conclusions

In conclusion, we have found that the PdI2/KI-catalyzed cycloisomerization of 2-(1-hydroxyprop-2-ynyl)phenols (1) to give 2-methylene-2,3-dihydrobenzofuran-3-ols (2) can be conveniently carried out in BmimBF4 as the reaction medium. When compared with MeOH [18], the use of BmimBF4 as the solvent required a higher temperature (100 °C vs. 40 °C) and a longer reaction time (5 h vs. 2 h); moreover, the yields obtained in BmimBF4 were similar or slightly inferior with respect to those obtained under the “classical” conditions (using MeOH as the solvent) [18]. However, the use of the ionic liquid has allowed to recycle the solvent-catalytic system several times, without appreciable loss of catalytic activity. Moreover, in BmimBF4, 2-methylene-2,3-dihydrobenzofuran-3-ols (2) could be expediently converted into functionalized benzofurans (2-hydroxymethylbenzofurans 3 or 2-methoxymethylbenzofurans 4) in a one-pot fashion by subsequent acid-catalyzed allylic isomerization or allylic nucleophilic substitution.

Acknowledgments

Thanks are due to the European Commission, FSE (Fondo Sociale Europeo) and Calabria Region for a fellowship grant to R.M.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Adcock, H.V.; Davies, P.W. π-Acid mediated insertion of alkynes into carbon-heteroatom σ-bonds. Synthesis 2012, 44, 3401–3420. [Google Scholar] [CrossRef]
  2. Yamamoto, Y. Transition-metal-catalyzed cycloisomerizations of α,ω-dienes. Chem. Rev. 2012, 112, 4736–4769. [Google Scholar] [CrossRef]
  3. Watson, I.D.G.; Toste, F.D. Catalytic enantioselective carbon-carbon bond formation using cycloisomerization reactions. Chem. Sci. 2012, 3, 2899–2919. [Google Scholar] [CrossRef]
  4. Marinetti, A.; Jullien, H.; Voituriez, A. Enantioselective, transition metal catalyzed cycloisomerizations. Chem. Soc. Rev. 2012, 41, 4884–4908. [Google Scholar] [CrossRef]
  5. Herndon, J.W. The Chemistry of the carbon-transition metal double and triple bond: Annual survey covering the year 2009. Coord. Chem. Rev. 2011, 255, 3–100. [Google Scholar] [CrossRef]
  6. Krause, N.; Winter, C. Gold-catalyzed nucleophilic cyclization of functionalized allenes: A powerful access to carbo- and heterocycles. Chem. Rev. 2011, 111, 1994–2009. [Google Scholar] [CrossRef]
  7. Belmont, P.; Parker, E. Silver and gold catalysis for cycloisomerization reactions. Eur. J. Org. Chem. 2009, 2009, 6075–6089. [Google Scholar] [CrossRef]
  8. Soriano, E.; Marco-Contelles, J. Mechanistic insights on the cycloisomerization of polyunsaturated precursors catalyzed by platinum and gold complexes. Acc. Chem. Res. 2009, 42, 1026–1036. [Google Scholar] [CrossRef]
  9. Majumdar, K.C.; Debnath, P.; Roy, B. Metal-catalyzed heterocyclization: Formation of five- and six-membered oxygen heterocycles through carbon-oxygen bond forming reactions. Heterocycles 2009, 78, 2661–2728. [Google Scholar] [CrossRef]
  10. Zeni, G.; Larock, R.C. Synthesis of heterocycles via palladium π-olefin and π-alkyne chemistry. Chem. Rev. 2004, 104, 2285–2309. [Google Scholar] [CrossRef]
  11. Gabriele, B.; Salerno, G.; Costa, M. PdI2-catalyzed synthesis of heterocycles. Synlett 2004, 14, 2468–2483. [Google Scholar] [CrossRef]
  12. Gabriele, B.; Veltri, L.; Plastina, P.; Mancuso, R.; Vetere, M.V.; Maltese, V. Copper-catalyzed synthesis of substituted furans and pyrroles by heterocyclodehydration and tandem heterocyclodehydration-hydration of 3-yne-1,2-diols and 1-amino-3-yn-2-ol derivatives. J. Org. Chem. 2013, 78, 4919–4928. [Google Scholar] [CrossRef]
  13. Spina, R.; Colacino, E.; Gabriele, B.; Salerno, G.; Martinez, J.; Lamaty, F. Synthesis of pyrrolin-4-ones by Pt-catalyzed cycloisomerization in PEG under microwaves. J. Org. Chem. 2013, 78, 2698–2702. [Google Scholar] [CrossRef]
  14. Gabriele, B.; Mancuso, R.; Veltri, L.; Maltese, V.; Salerno, G. Synthesis of substituted thiophenes by palladium-catalyzed heterocyclodehydration of 1-mercapto-3-yn-2-ols in conventional and nonconventional solvents. J. Org. Chem. 2012, 77, 9905–9909. [Google Scholar] [CrossRef]
  15. Gabriele, B.; Mancuso, R.; Lupinacci, E.; Veltri, L.; Salerno, G.; Carfagna, C. Synthesis of benzothiophene derivatives by Pd-catalyzed or radical-promoted heterocyclodehydration of 1-(2-mercaptophenyl)-2-yn-1-ols. J. Org. Chem. 2011, 76, 8277–8286. [Google Scholar] [CrossRef]
  16. Gabriele, B.; Plastina, P.; Vetere, M.V.; Veltri, L.; Mancuso, R.; Salerno, G. A simple and convenient synthesis of substituted furans and pyrroles by CuCl2-Catalyzed heterocyclodehydration of 3-yne-1,2-diols and N-Boc- or N-Tosyl-1-amino-3-yn-2-ols. Tetrahedron Lett. 2010, 51, 3565–3567. [Google Scholar] [CrossRef]
  17. Gabriele, B.; Mancuso, R.; Lupinacci, E.; Spina, R.; Salerno, G.; Veltri, L.; Dibenedetto, A. Recyclable catalytic synthesis of substituted quinolines: Copper-catalyzed heterocyclization of 1-(2-aminoaryl)-2-yn-1-ols in ionic liquids. Tetrahedron 2009, 65, 8507–8512. [Google Scholar] [CrossRef]
  18. Gabriele, B.; Mancuso, R.; Salerno, G. A novel synthesis of 2-functionalized benzofurans by palladium-catalyzed cycloisomerization of 2-(1-hydroxyprop-2-ynyl)phenols followed by acid-catalyzed allylic isomerization or allylic nucleophilic substitution. J. Org. Chem. 2008, 73, 7336–7341. [Google Scholar] [CrossRef]
  19. Plastina, P.; Gabriele, B.; Salerno, G. Palladium-catalyzed oxidative aminocarbonylation of alkynols. Synthesis 2007, 3083–3087. [Google Scholar] [CrossRef]
  20. Gabriele, B.; Mancuso, R.; Salerno, G.; Ruffolo, G.; Plastina, P. Novel and convenient synthesis of substituted quinolines by copper- or palladium-catalyzed cyclodehydration of 1-(2-aminoaryl)-2-yn-1-ols. J. Org. Chem. 2007, 72, 6873–6877. [Google Scholar] [CrossRef]
  21. Greaves, T.L.; Drummond, C.J. Solvent nanostructure, the solvophobic effect and amphiphile self-assembly in ionic liquids. Chem. Soc. Rev. 2013, 42, 1096–1120. [Google Scholar] [CrossRef]
  22. Rehman, A.; Zeng, X. Ionic liquids as green solvents and electrolytes for robust chemical sensor development. Acc. Chem. Res. 2012, 45, 1667–1677. [Google Scholar] [CrossRef]
  23. Patel, D.D.; Lee, J.-M. Applications of ionic liquids. Chem. Rec. 2012, 12, 329–355. [Google Scholar] [CrossRef]
  24. Wong, W.-L.; Wong, K.-Y. Recent development in functionalized ionic liquids as reaction media and promoters. Can. J. Chem. 2012, 90, 1–16. [Google Scholar] [CrossRef]
  25. Payagala, T.; Armstrong, D.W. Chiral ionic liquids: A compendium of syntheses and applications (2005–2012). Chirality 2012, 24, 17–53. [Google Scholar] [CrossRef]
  26. de Maria, P.D.; Yang, Z.; Kohlmann, C.; Greiner, L.; Lozano, P.; García-Verdugo, E.; Zhao, H.; Gamenara, D.; Saenz Méndez, P.; Dennewald, D.; et al. Ionic Liquids in Biotransformations and Organocatalysis: Solvents and Beyond; Domínguez de Maria, P., Ed.; Wiley-VCH: Weinheim, Germany, 2012. [Google Scholar]
  27. Dupont, J. From molten salts to ionic liquids: A “nano” journey. Acc. Chem. Res. 2011, 44, 1223–1231. [Google Scholar] [CrossRef]
  28. Hallett, J.P.; Welton, T. Room-temperature ionic liquids: Solvents for synthesis and catalysis. Chem. Rev. 2011, 111, 3508–3576. [Google Scholar] [CrossRef]
  29. Hubbard, C.D.; Illner, P.; van Eldik, R. Understanding chemical reaction mechanisms in ionic liquids: Successes and challenges. Chem. Soc. Rev. 2011, 40, 272–290. [Google Scholar] [CrossRef]
  30. Zhang, Q.; Zhang, S.; Deng, Y. Recent advances in ionic liquid catalysis. Green Chem. 2011, 13, 2619–2637. [Google Scholar] [CrossRef]
  31. Wilkes, J.S.; Wasserscheid, P.; Welton, T.; Gordon, C.M.; Muldoon, M.J.; Wagner, M.; Hilgers, C.; Davis, J.H.; Holbrey, J.D.; Rogers, R.D.; et al. Ionic Liquids in Synthesis, 2nd ed.; Wasserscheid, P., Welton, T., Eds.; Wiley-VCH: Weinheim, Germany, 2008. [Google Scholar]
  32. Ohtaka, A. Recyclable polymer-supported nanometal catalysts in water. Chem. Rec. 2013, 13, 274–285. [Google Scholar] [CrossRef]
  33. Gawande, M.B.; Branco, P.S.; Varma, R.S. Nano-magnetite (Fe3O4) as a support for recyclable catalysts in the development of sustainable methodologies. Chem. Soc. Rev. 2013, 42, 3371–3393. [Google Scholar] [CrossRef]
  34. Colacino, E.; Martinez, J.; Lamaty, F.; Petrikeeva, L.S.; Khemchyan, L.L.; Ananikov, V.P.; Beletskaya, I.P. PEG as an alternative reaction medium in metal-mediated transformations. Coord. Chem. Rev. 2012, 256, 2893–2920. [Google Scholar] [CrossRef]
  35. Yuan, D.; Huang, B. Progress in organic synthesis reactions catalyzed by palladium supported on magnetic nanoparticles. Chin. J. Org. Chem. 2012, 32, 1368–1379. [Google Scholar] [CrossRef]
  36. Liu, H.; Jia, Z.; Ji, S. Research progress in supported catalysts for Heck reaction. Chin. J. Catal. 2012, 33, 757–767. [Google Scholar]
  37. Gu, Y. Multicomponent reactions in unconventional solvents: State of the art. Green Chem. 2012, 14, 2091–2128. [Google Scholar] [CrossRef]
  38. Arpad, M. Efficient, selective, and recyclable palladium catalysts in carbon-carbon coupling reactions. Chem. Rev. 2011, 111, 2251–2320. [Google Scholar] [CrossRef]
  39. Beletskaya, I.P.; Tyurin, V. Recyclable nanostructured catalytic systems in modern environmentally friendly organic synthesis. Molecules 2010, 15, 4792–4814. [Google Scholar] [CrossRef]
  40. Bellina, F.; Chiappe, C. The Heck reaction in ionic liquids: Progress and challenges. Molecules 2010, 15, 2211–2245. [Google Scholar] [CrossRef]
  41. Lim, C.W.; Lee, I.S. Magnetically recyclable nanocatalyst systems for the organic reactions. Nano Today 2010, 5, 412–434. [Google Scholar] [CrossRef]
  42. Gabriele, B.; Mancuso, R.; Salerno, G. Acid-catalysed or radical-promoted allylic substitution of 2-methylene-2,3-dihydrobenzofuran-3-ols with thiol derivatives: A novel and expedient synthesis of 2-(thiomethyl)benzofurans. Eur. J. Org. Chem. 2010, 2010, 3459–3464. [Google Scholar] [CrossRef]
  43. Gabriele, B.; Mancuso, R.; Salerno, G.; Plastina, P. A novel palladium-catalyzed dicarbonylation process leading to coumarins. J. Org. Chem. 2008, 73, 756–759. [Google Scholar] [CrossRef]
  44. Crosthwaite, J.M.; Aki, S.N.V.K.; Maginn, E.J.; Brennecke, J.F. Liquid phase behavior of imidazolium-based ionic liquids with alcohols. J. Phys. Chem. B 2004, 108, 5113–5119. [Google Scholar]
  • Sample Availability: Samples of the compounds 2a–j, 3a–j, and 4a–j are available from the authors.

Share and Cite

MDPI and ACS Style

Mancuso, R.; Gabriele, B. A Recyclable Palladium-Catalyzed Synthesis of 2-Methylene-2,3-Dihydrobenzofuran-3-ols by Cycloisomerization of 2-(1-Hydroxyprop-2-ynyl)phenols in Ionic Liquids. Molecules 2013, 18, 10901-10911. https://doi.org/10.3390/molecules180910901

AMA Style

Mancuso R, Gabriele B. A Recyclable Palladium-Catalyzed Synthesis of 2-Methylene-2,3-Dihydrobenzofuran-3-ols by Cycloisomerization of 2-(1-Hydroxyprop-2-ynyl)phenols in Ionic Liquids. Molecules. 2013; 18(9):10901-10911. https://doi.org/10.3390/molecules180910901

Chicago/Turabian Style

Mancuso, Raffaella, and Bartolo Gabriele. 2013. "A Recyclable Palladium-Catalyzed Synthesis of 2-Methylene-2,3-Dihydrobenzofuran-3-ols by Cycloisomerization of 2-(1-Hydroxyprop-2-ynyl)phenols in Ionic Liquids" Molecules 18, no. 9: 10901-10911. https://doi.org/10.3390/molecules180910901

APA Style

Mancuso, R., & Gabriele, B. (2013). A Recyclable Palladium-Catalyzed Synthesis of 2-Methylene-2,3-Dihydrobenzofuran-3-ols by Cycloisomerization of 2-(1-Hydroxyprop-2-ynyl)phenols in Ionic Liquids. Molecules, 18(9), 10901-10911. https://doi.org/10.3390/molecules180910901

Article Metrics

Back to TopTop