Preventive Effects of Citrus unshiu Peel Extracts on Bone and Lipid Metabolism in OVX Rats
Abstract
:1. Introduction
2. Results and Discussion
2.1. Analysis of Hesperidin from Dried Citrus unshiu Peel Extracts
2.2. Effect of DCPE on Body Weight and Serum Lipid Concentrations in OVX Rats
2.3. Effect of DCPE on OVX-Induced Fatty Liver
Groups | TC | TG | HDL-c | LDL-c | CRI | AI |
---|---|---|---|---|---|---|
(mg/dL) | (mg/dL) | (mg/dL) | (mg/dL) | |||
I | 75.8 ± 8.5 | 78.5 ± 5.2 | 50.5 ± 4.1 | 15.7 ± 6.1 | 1.7 ± 0.2 | 0.3 ± 0.2 |
II | 97.4 ± 5.1 c | 98.3 ± 6.4 c | 41.5 ± 2.3 | 33.6 ± 4.2 c | 2.3 ± 0.3 c | 0.8 ± 0.2 c |
III | 90.0 ± 4.8 | 85.7 ± 8.7 a | 44.8 ± 4.3 | 18.3 ± 5.4 a | 2.0 ± 0.2 a | 0.4 ± 0.1 a |
IV | 98.2 ± 5.8 | 90.2 ± 5.4 | 42.5 ± 3.8 | 27.3 ± 4.2 | 2.3 ± 0.3 | 0.6 ± 0.1 |
V | 92.0 ± 5.4 | 88.7 ± 8.7 | 42.5 ± 4.8 | 26.3 ± 5.4 | 2.2 ± 0.2 | 0.6 ± 0.2 |
VI | 85.0 ± 6.5 a | 80.9 ± 5.6 a | 48.9 ± 4.6 | 17.9 ± 4.8 a | 1.7 ± 0.2 a | 0.4 ± 0.3 b |
Groups | Serum (mg/dL) | Liver lipid (mg/g wet wt) | ||
---|---|---|---|---|
AST | ALT | TC | TG | |
I | 115.1 ± 11.6 | 62.1 ± 6.9 | 6.1 ± 0.7 | 38.2 ± 5.9 |
II | 144.4 ± 25.7 c | 96.5 ± 6.6 c | 10.1 ± 0.7 c | 69.8 ± 6.4 c |
III | 121.2 ± 17.4 a | 72.5 ± 5.6 a | 7.0 ± 0.5 a | 54.5 ± 6.2 a |
IV | 132.3 ± 16.4 | 84.5 ± 6.6 | 8.2 ± 0.6 | 70.5 ± 4.2 |
V | 123.1 ± 16.4 a | 75.3 ± 4.9 a | 7.2 ± 0.6 a | 52.8 ± 6.8 a |
VI | 118.6 ± 10.5 a | 67.5 ± 6.8 a | 6.5 ± 0.5 a | 44.1 ± 5.8 a |
2.4. Effect of DCPE on BMD and Organ Weights in OVX Rats
2.5. Effect of DCPE on Bone Marker in OVX Rats
2.6. Discussion
3. Experimental
3.1. Sample Preparation and HPLC Analysis
3.2. Animals and Treatments
3.3. BMD Measurements
3.4. Serum Lipid, Estradiol and Bone Marker Analysis
3.5. Liver Histological Analysis
3.6. Statistical Analysis
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Lim, D.W.; Lee, Y.; Kim, Y.T. Preventive Effects of Citrus unshiu Peel Extracts on Bone and Lipid Metabolism in OVX Rats. Molecules 2014, 19, 783-794. https://doi.org/10.3390/molecules19010783
Lim DW, Lee Y, Kim YT. Preventive Effects of Citrus unshiu Peel Extracts on Bone and Lipid Metabolism in OVX Rats. Molecules. 2014; 19(1):783-794. https://doi.org/10.3390/molecules19010783
Chicago/Turabian StyleLim, Dong Wook, Youngseok Lee, and Yun Tai Kim. 2014. "Preventive Effects of Citrus unshiu Peel Extracts on Bone and Lipid Metabolism in OVX Rats" Molecules 19, no. 1: 783-794. https://doi.org/10.3390/molecules19010783