Sensory TRP Channel Interactions with Endogenous Lipids and Their Biological Outcomes
Abstract
:1. Introduction
2. Roles of Sensory TRP Channels in Pain Sensation
2.1. Vanilloid Subtype 1 (TRPV1)
2.2. TRPV2
2.3. TRPV3
2.4. TRPV4
2.5. Ankyrin Subtype 1 (TRPA1)
2.6. Melastatin Subtype 8 (TRPM8)
2.7. Neurogenic Inflammation Mediated via TRP Activation
3. Endogenous Lipid Interaction of Sensory TRPs
3.1. Second Messenger Hypothesis
3.1.1. PLA2-LOX Metabolites
3.1.2. Lipids in the PLC Cascade
3.2. Intercellular Transmitter Hypothesis
3.2.1. Amine Conjugates of Fatty Acid
3.2.2. Hydroperoxy Eicosanoids
3.2.3. Epoxy Eicosanoids
3.2.4. Isoprenyl Substances
3.2.5. Covalent Ligands on TRPA1
3.3. Membrane Incorporation Hypothesis?
3.4. Silencing Ligands or Negative Modifications
4. Conclusions and Perspectives
Sensory TRP channels | Endogenous lipidergic activators | Endogenous lipidergic inhibitors |
---|---|---|
TRPA1 | Arachidonic acid, DAG [64], PIP2 [120,121] Cyclopentenone prostaglandin (PGs) [179,180,181,182] Nitro-oleic acid [185] 4-ONE, 4-HNE, 4-HHE [179,186,187] | 17(S)-resolvin D1 [228] Resolvin D2 [231] |
TRPV1 | 12(S)-HpETE, 15(S)-HpETE [87,103] oxoODEs, HODEs [111] DAG [112,113] NADA, OLDA, OEA, retinoic acid [86,126,128,129,130] | Resolvin D2 [231] Resolvin E1, neuroprotectin D1, maresin 1 [229,230,231,232] |
TRPV3 | arachidonic acid [137] FPP [161] | 17(R)-resolvin D1 [227] 17(S)-resolvin D1 [228] |
TRPV4 | EETs [138,151] DMAPP [169] | 17(S)-resolvin D1 [228] |
TRPM8 | PIP2 [108] LPC, LPI, LPS [209,211,212] | EPA, DHA, arachidonic acid [233] |
Acknowledgments
Conflicts of Interest
References
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Yoo, S.; Lim, J.Y.; Hwang, S.W. Sensory TRP Channel Interactions with Endogenous Lipids and Their Biological Outcomes. Molecules 2014, 19, 4708-4744. https://doi.org/10.3390/molecules19044708
Yoo S, Lim JY, Hwang SW. Sensory TRP Channel Interactions with Endogenous Lipids and Their Biological Outcomes. Molecules. 2014; 19(4):4708-4744. https://doi.org/10.3390/molecules19044708
Chicago/Turabian StyleYoo, Sungjae, Ji Yeon Lim, and Sun Wook Hwang. 2014. "Sensory TRP Channel Interactions with Endogenous Lipids and Their Biological Outcomes" Molecules 19, no. 4: 4708-4744. https://doi.org/10.3390/molecules19044708