Comparative Study on the Antioxidant and Anti-Toxoplasma Activities of Vanillin and Its Resorcinarene Derivative
Abstract
:1. Introduction
2. Results and Discussion
2.1. Infrared Analysis
Assignment | Resorcinol | Vanillin | Resvan |
---|---|---|---|
νO-H (phenol) | 3447 | 3447 | 3411 |
νC-H (aromatic) | 3012 | 3013 | 3008 |
νC-H (aldehyde) | 2855 | ||
νC=O (aldehyde) | 1666 | ||
νC-C (benzene) | 1616 | 1596 | 1616 and 1518 |
νCH3 (methoxy) | 1463 | 1463 | |
δCH (methine bridge) | 1430 | ||
νC-CHO (aldehyde) | 1265 | ||
νC-O (ether) | 1200 | 1204 | |
δCH3 (methoxy) | 1172 | ||
νC-OH | 1150 | 1155 | 1154 |
δCCH (in-plane) | 1123 | 1123 | |
νO-CH3 | 1028 | 1030 | |
δC-C-CHO (out-of-plane) | 732 | ||
δC-C=O (in-plane) | 588 |
2.2. Electronic Spectra Analysis
2.3. Citotoxicity and Acute Toxicity
2.4. Antioxidant Activity
2.5. Determination of in Vivo Antiprotozoal Activity of the Compounds
3. Experimental
3.1. Chemicals
3.2. Synthesis of C-4-Hydroxy-3-Methoxyphenylcalix [4] Resorcinarene (Resvan)
3.3. Apparatus
3.4. Cytotoxicity Assay
3.5. Animals
3.6. Acute Toxicity
3.7. Scavenging Activity on 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Radicals
3.8. Determination of in Vivo Antiprotozoal Activity of the Compounds
3.9. Statistical Analysis
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Oliveira, C.B.S.; Meurer, Y.S.R.; Oliveira, M.G.; Medeiros, W.M.T.Q.; Silva, F.O.N.; Brito, A.C.F.; Pontes, D.D.L.; Andrade-Neto, V.F. Comparative Study on the Antioxidant and Anti-Toxoplasma Activities of Vanillin and Its Resorcinarene Derivative. Molecules 2014, 19, 5898-5912. https://doi.org/10.3390/molecules19055898
Oliveira CBS, Meurer YSR, Oliveira MG, Medeiros WMTQ, Silva FON, Brito ACF, Pontes DDL, Andrade-Neto VF. Comparative Study on the Antioxidant and Anti-Toxoplasma Activities of Vanillin and Its Resorcinarene Derivative. Molecules. 2014; 19(5):5898-5912. https://doi.org/10.3390/molecules19055898
Chicago/Turabian StyleOliveira, Claudio B. S., Ywlliane S. R. Meurer, Marianne G. Oliveira, Wendy M. T. Q. Medeiros, Francisco O. N. Silva, Ana C. F. Brito, Daniel De L. Pontes, and Valter F. Andrade-Neto. 2014. "Comparative Study on the Antioxidant and Anti-Toxoplasma Activities of Vanillin and Its Resorcinarene Derivative" Molecules 19, no. 5: 5898-5912. https://doi.org/10.3390/molecules19055898