Palladium Catalyzed Heck Arylation of 2,3-Dihydrofuran—Effect of the Palladium Precursor
Abstract
:1. Introduction
2. Results and Discussion
2.1. Arylation of DHF at the Presence of [DDA][L-PRO]
2.2. Arylation of DHF at the Presence of [BA][L-PRO]
2.3. Arylation of DHF at the Presence of [NBu4][L-PRO]
2.4. Arylation of DHF at the Presence of [NBu4][L-LAC]
2.5. Arylation of DHF with [PdCl(allyl)]2 Precursor
(a) | (b) | ||||
---|---|---|---|---|---|
| | ||||
L-proline | Pd(L-PRO)2 | [BA][L-PRO] | [BA][L-PRO]/[PdCl(allyl)]2 | ||
Proton | δ (ppm) | δ (ppm) | δ (ppm) | δ (ppm) | |
CH-2 | 4.04 t (J = 7.8 Hz) | 3.90 t (J = 8.4 Hz) | 3.70 m | 3.71 m | |
CH2-3a | 3.32 m | 3.14 m | 3.10 m | 2.19 m | |
CH2-3b | 3.26 m | 2.93 m | |||
CH2- 4a | 2.26 m | 2.22 m | 2.08 m | 2.00 m | |
CH2-4b | 1.99 m | 1.95 m | 1.92 m | 1.85 m | |
CH2-5 | 1.92 m | 2.04 m; 1.71 m | 1.70 m | 1.75 m |
3. Experimental
General Information
Heck Reaction
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Morel, A.; Trzeciak, A.M.; Pernak, J. Palladium Catalyzed Heck Arylation of 2,3-Dihydrofuran—Effect of the Palladium Precursor. Molecules 2014, 19, 8402-8413. https://doi.org/10.3390/molecules19068402
Morel A, Trzeciak AM, Pernak J. Palladium Catalyzed Heck Arylation of 2,3-Dihydrofuran—Effect of the Palladium Precursor. Molecules. 2014; 19(6):8402-8413. https://doi.org/10.3390/molecules19068402
Chicago/Turabian StyleMorel, Adam, Anna M. Trzeciak, and Juliusz Pernak. 2014. "Palladium Catalyzed Heck Arylation of 2,3-Dihydrofuran—Effect of the Palladium Precursor" Molecules 19, no. 6: 8402-8413. https://doi.org/10.3390/molecules19068402