Is a Highly Linear Relationship Between the Dose of Quercetin and the Pharmacological Effect Possible? — A Comment on Liu, et al. Evaluation of Antioxidant and Immunity Activities of Quercetin in Isoproterenol-Treated Rats. Molecules 2012, 17, 4281–4291
- No information is provided on how the quercetin was dissolved and administered.
- There are no illustrative ECG measurements nor any comment on how the ECG signals were measured, this necessitates comments due to the measured T wave depression data.
- Heart index is not specified and since this is not a very common parameter, how was it calculated?
- The statistical test used by the authors in the comparison of data is not mentioned.
- Did all isoprenaline-treated animals survive the experiment?
References
- Liu, H.; Zhang, L.; Lu, S. Evaluation of antioxidant and immunity activities of quercetin in isoproterenol-treated rats. Molecules 2012, 17, 4281–4291. [Google Scholar] [CrossRef]
- Beinfield, W.H.; Lehr, D. QRS-T variations in the rat electrocardiogram. Am. J. Physiol. 1968, 214, 197–204. [Google Scholar]
- Cialdella-Kam, L.; Nieman, D.C.; Sha, W.; Meaney, M.P.; Knab, A.M.; Shanely, R.A. Dose-response to 3 months of quercetin-containing supplements on metabolite and quercetin conjugate profile in adults. Br. J. Nutr. 2012, 1–11. [Google Scholar]
- Ader, P.; Wessmann, A.; Wolffram, S. Bioavailability and metabolism of the flavonol quercetin in the pig. Free Radic. Biol. Med. 2000, 28, 1056–1067. [Google Scholar] [CrossRef]
- De Boer, V.C.; Dihal, A.A.; van der Woude, H.; Arts, I.C.; Wolffram, S.; Alink, G.M.; Rietjens, I.M.; Keijer, J.; Hollman, P.C. Tissue distribution of quercetin in rats and pigs. J. Nutr. 2005, 135, 1718–1725. [Google Scholar]
- Egert, S.; Wolffram, S.; Bosy-Westphal, A.; Boesch-Saadatmandi, C.; Wagner, A.E.; Frank, J.; Rimbach, G.; Mueller, M.J. Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J. Nutr. 2008, 138, 1615–1621. [Google Scholar]
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Mladěnka, P.; Hrdina, R.; Filipský, T.; Říha, M.; Palicka, V. Is a Highly Linear Relationship Between the Dose of Quercetin and the Pharmacological Effect Possible? — A Comment on Liu, et al. Evaluation of Antioxidant and Immunity Activities of Quercetin in Isoproterenol-Treated Rats. Molecules 2012, 17, 4281–4291. Molecules 2014, 19, 9606-9609. https://doi.org/10.3390/molecules19079606
Mladěnka P, Hrdina R, Filipský T, Říha M, Palicka V. Is a Highly Linear Relationship Between the Dose of Quercetin and the Pharmacological Effect Possible? — A Comment on Liu, et al. Evaluation of Antioxidant and Immunity Activities of Quercetin in Isoproterenol-Treated Rats. Molecules 2012, 17, 4281–4291. Molecules. 2014; 19(7):9606-9609. https://doi.org/10.3390/molecules19079606
Chicago/Turabian StyleMladěnka, Přemysl, Radomír Hrdina, Tomáš Filipský, Michal Říha, and Vladimir Palicka. 2014. "Is a Highly Linear Relationship Between the Dose of Quercetin and the Pharmacological Effect Possible? — A Comment on Liu, et al. Evaluation of Antioxidant and Immunity Activities of Quercetin in Isoproterenol-Treated Rats. Molecules 2012, 17, 4281–4291" Molecules 19, no. 7: 9606-9609. https://doi.org/10.3390/molecules19079606