Vasorelaxation Induced by a New Naphthoquinone-Oxime is Mediated by NO-sGC-cGMP Pathway
Abstract
:1. Introduction
2. Results and Discussion
2.1. Oxime S1 Reduces Blood Pressure in Conscious Rats
2.2. Oxime S1 Produces Endothelium-Independent Relaxations in Both Aorta and Superior Mesenteric Artery Rings
2.3. Oxime S1 Produces Vasorelaxation via Activation of the NO-sGC-cGMP Pathway
2.4. Vasorelaxation Induced by Oxime S1 is also Mediated by Activation of K+ Channels
2.5. Oxime S1 Releases Nitric Oxide When in Solution Acting as a Nitric Oxide Donor
3. Experimental
3.1. Animals
3.2. Drugs and Solutions
3.3. Cardiovascular Parameters in Vivo
3.4. Studies on Aortic and Mesenteric Artery Rings Isolated from Rats
3.5. Determination of Nitric Oxide Release Using NO Microsensors
3.6. Statistical Analysis
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Dantas, B.P.V.; Ribeiro, T.P.; Assis, V.L.; Furtado, F.F.; Assis, K.S.; Alves, J.S.; Silva, T.M.S.; Camara, C.A.; França-Silva, M.S.; Veras, R.C.; et al. Vasorelaxation Induced by a New Naphthoquinone-Oxime is Mediated by NO-sGC-cGMP Pathway. Molecules 2014, 19, 9773-9785. https://doi.org/10.3390/molecules19079773
Dantas BPV, Ribeiro TP, Assis VL, Furtado FF, Assis KS, Alves JS, Silva TMS, Camara CA, França-Silva MS, Veras RC, et al. Vasorelaxation Induced by a New Naphthoquinone-Oxime is Mediated by NO-sGC-cGMP Pathway. Molecules. 2014; 19(7):9773-9785. https://doi.org/10.3390/molecules19079773
Chicago/Turabian StyleDantas, Bruna P. V., Thaís P. Ribeiro, Valéria L. Assis, Fabíola F. Furtado, Kívia S. Assis, Jeziane S. Alves, Tania M.S. Silva, Celso A. Camara, Maria S. França-Silva, Robson C. Veras, and et al. 2014. "Vasorelaxation Induced by a New Naphthoquinone-Oxime is Mediated by NO-sGC-cGMP Pathway" Molecules 19, no. 7: 9773-9785. https://doi.org/10.3390/molecules19079773