Three New Lanostanoids from the Mushroom Ganoderma tropicum
Abstract
:1. Introduction
2. Results and Discussion
H | 1 | 2 | 3 |
---|---|---|---|
1α | 2.75 m | 2.71 m | 2.79 m |
1β | 0.92 m | 0.94 m | 0.97 m |
2α | 2.08 m | 2.18 m | 2.01 m |
2β | 1.64 m | 1.63 m | 1.67 m |
3α | 3.21 dd (J = 5.2, 11.0) | 3.15 dd (J = 4.8,11.8) | 3.60 dd (J = 5.0,11.8) |
5α | 0.89 d (J = 4.5) | 0.95 d (J = 3.0) | 1.40 d (J =12.5) |
6α | 2.10 m | 2.30 m | 2.03 m |
6β | 1.57 m | ||
7α | 4.59 dd (J = 7.2, 10.4) | 4.53 dd (J = 7.4, 10.5) | 4.56 dd (J = 7.3, 10.0) |
12α | 3.11 d (J = 15.6) | 2.87 d (J = 15.2) | 3.00 d (J = 14.4) |
12β | 2.25 d (J = 15.6) | 2.41 d (J = 15.2) | 2.75 d (J = 14.4) |
15β | 4.80 dd (J = 8.1, 8.6) | 4.77 dd (J = 7.2, 9.3) | 5.42 s |
16α | 2.40 dd (J = 8.1, 15.0) | 1.81 m | 5.25 s |
16β | 2.30 m | ||
17α | - | 1.93 m | - |
18 | 1.14 s | 0.98 s | 1.01 s |
19 | 1.24 s | 1.25 s | 1.26 s |
20 | 2.28 m | 2.05 m | 2.63 m |
21 | 1.01 d (J = 6.9) | 0.89 d (J = 6.4) | 1.03 d (J = 6.8) |
22 | 1.83 d (J = 14.0, α-H) | 2.60 m | 2.53 m |
2.70 dd (J = 6.7, 14.0, β-H) | 2.50 m | 2.30 m | |
24 | 2.04 m (β-H) | 4.39 d (J = 5.0) | 2.85 m |
2.48 dd (J = 8.1, 12.8, α-H) | |||
25 | 2.94 m | 2.88 m | 2.86 m |
27 | 1.26 d (J = 7.2) | 1.09 d (J = 7.1) | 1.15 d (J = 7.0) |
28 | 1.02 s | 1.02 s | 3.53 d (J = 11.2) |
3.31 d (J = 11.2) | |||
29 | 0.84 s | 0.84 s | 0.72 s |
30 | 1.32 s | 1.26 s | 1.28 s |
C | 1 | 2 | 3 |
---|---|---|---|
1 | 34.7 (t) | 35.9 (t) | 35.4 (t) |
2 | 27.9 (t) | 28.8 (t) | 28.0 (t) |
3 | 78.4 (d) | 73.2 (d) | 72.4 (d) |
4 | 38.8 (s) | 39.7 (s) | 43.3 (s) |
5 | 49.1 (d) | 50.4 (d) | 52.9 (d) |
6 | 27.7 (t) | 29.0 (t) | 28.5 (t) |
7 | 69.2 (d) | 70.1 (d) | 69.7 (d) |
8 | 158.8 (s) | 161.3 (s) | 162.3 (s) |
9 | 141.9 (s) | 143.5 (s) | 142.7 (s) |
10 | 38.7 (s) | 39.7 (s) | 39.8 (s) |
11 | 200.2 (s) | 202.3 (s) | 201.9 (s) |
12 | 47.2 (t) | 53.2 (t) | 48.5 (t) |
13 | 49.7 (s) | 48.4 (s) | 53.0 (s) |
14 | 54.5 (s) | 55.3 (s) | 57.6 (s) |
15 | 73.2 (d) | 78.9 (d) | 78.1 (d) |
16 | 45.0 (t) | 37.1 (t) | 125.6 (d) |
17 | 94.9 (s) | 49.0 (d) | 155.9 (s) |
18 | 19.9 (q) | 19.8 (q) | 20.7 (q) |
19 | 19.5 (q) | 17.5 (q) | 20.0 (q) |
20 | 44.0 (d) | 33.3 (d) | 28.6 (d) |
21 | 18.3 (q) | 20.2 (q) | 22.7 (q) |
22 | 44.7 (t) | 46.7 (t) | 49.5 (t) |
23 | 113.4 (s) | 212.9 (s) | 209.9 (s) |
24 | 44.8 (t) | 78.9 (d) | 47.4 (d) |
25 | 35.7 (d) | 43.2 (d) | 35.9 (d) |
26 | 179.2 (s) | 177.6 (s) | 179.6 (s) |
27 | 15.1 (q) | 11.4 (q) | 17.5 (q) |
28 | 28.3 (q) | 28.7 (q) | 66.2 (t) |
29 | 15.8 (q) | 16.4 (q) | 13.0 (q) |
30 | 21.4 (q) | 20.0 (q) | 23.3 (q) |
3. Experimental Section
3.1. General Information
3.2. Fungal Material
3.3. Extraction and Isolation
3.4. Ganotropic Acid (1)
3.5. 3β,7β,15α,24-Tetrahydroxy-11,23-dioxo-lanost-8-en-26-oic Acid (2)
3.6. 3β,7β,15α,28-Tetrahydroxy-11,23-dioxo-lanost-8,16-dien-26-oic Acid (3)
3.7. Bioassay of AChE Inhibitory Activity
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
Supplementary Materials
References
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Zhang, S.-S.; Wang, Y.-G.; Ma, Q.-Y.; Huang, S.-Z.; Hu, L.-L.; Dai, H.-F.; Yu, Z.-F.; Zhao, Y.-X. Three New Lanostanoids from the Mushroom Ganoderma tropicum. Molecules 2015, 20, 3281-3289. https://doi.org/10.3390/molecules20023281
Zhang S-S, Wang Y-G, Ma Q-Y, Huang S-Z, Hu L-L, Dai H-F, Yu Z-F, Zhao Y-X. Three New Lanostanoids from the Mushroom Ganoderma tropicum. Molecules. 2015; 20(2):3281-3289. https://doi.org/10.3390/molecules20023281
Chicago/Turabian StyleZhang, Shuang-Shuang, Yu-Guang Wang, Qing-Yun Ma, Sheng-Zhuo Huang, Li-Li Hu, Hao-Fu Dai, Zhi-Fang Yu, and You-Xing Zhao. 2015. "Three New Lanostanoids from the Mushroom Ganoderma tropicum" Molecules 20, no. 2: 3281-3289. https://doi.org/10.3390/molecules20023281