Influence of Solid Drug Delivery System Formulation on Poorly Water-Soluble Drug Dissolution and Permeability
Abstract
:1. Introduction
2. Results and Discussion
2.1. Droplet Size Analysis
2.2. Fourier-Transform Infrared Spectroscopy (FT-IR)
2.3. Differential Scanning Calorimetry (DSC)
2.4. Powder X-ray Diffraction Analysis (PXRD)
2.5. In Vitro Drug Release Profile
Pure Carbamazepine | Commercial Tablets | ||
---|---|---|---|
SMEDDS_1:1 | f1 | 62.17 | 56.50 |
f2 | 18.49 | 15.95 | |
SNEDDS_1:6 | f1 | 55.33 | 49.05 |
f2 | 24.40 | 22.17 | |
SD_1:6 | f1 | 54.86 | 44.02 |
f2 | 24.41 | 25.62 |
2.6. Parallel Artificial Membrane Permeability Assay (PAMPA)
Formulations | Papp × 10−6 (cm/s) |
---|---|
Carbamazepine | 11.77 ± 0.34 |
SD_1:6 | 16.12 ± 2.27 |
SNEDDS_1:6 | 19.12 ± 0.87 |
SMEDDS_1:1 | 21.42 ± 1.67 |
3. Experimental Section
3.1. Materials
3.2. Methods
3.2.1. Solid Dispersions
3.2.2. Solid Self-Microemulsifying Drug Delivery Systems (S-SMEDDS)
3.2.3. Solid Self-Nanoemulsifying Drug Delivery Systems (S-SNEDDS)
3.3. Photon Correlation Spectroscopy (PCS)
3.4. In Vitro Drug Release Studies
3.5. Characterization of Selected Formulations
3.5.1. Fourier-Transform Infrared Spectroscopy (FT-IR)
3.5.2. Differential Scanning Calorimetry (DSC)
3.5.3. Powder X-ray Diffraction Analysis (PXRD)
3.6. PAMPA Test
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Krstić, M.; Popović, M.; Dobričić, V.; Ibrić, S. Influence of Solid Drug Delivery System Formulation on Poorly Water-Soluble Drug Dissolution and Permeability. Molecules 2015, 20, 14684-14698. https://doi.org/10.3390/molecules200814684
Krstić M, Popović M, Dobričić V, Ibrić S. Influence of Solid Drug Delivery System Formulation on Poorly Water-Soluble Drug Dissolution and Permeability. Molecules. 2015; 20(8):14684-14698. https://doi.org/10.3390/molecules200814684
Chicago/Turabian StyleKrstić, Marko, Miljana Popović, Vladimir Dobričić, and Svetlana Ibrić. 2015. "Influence of Solid Drug Delivery System Formulation on Poorly Water-Soluble Drug Dissolution and Permeability" Molecules 20, no. 8: 14684-14698. https://doi.org/10.3390/molecules200814684