Hydrazonoyl Chlorides as Precursors for Synthesis of Novel Bis-Pyrrole Derivatives
Abstract
:1. Introduction
2. Results and Discussion
2.1. Chemistry
2.2. Antimicrobial Evaluation
2.3. Docking and Molecular Modeling
3. Materials and Methods
3.1. Chemistry
3.1.1. General
3.1.2. Synthesis of Bis-Pyrrole Derivatives 5a–e
3.2. Agar Diffusion Well Method to Determine the Antimicrobial Activity
3.3. Docking Studies
4. Conclusions
Acknowledgments
Conflicts of Interest
References
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Microorganisms | Compound Tested | Standard (30 µg/mL) | |||
---|---|---|---|---|---|
5a | 5b | 5d | 5e | ||
Fungi | Itraconazole | ||||
Aspergillus fumigatus (RCMB 002003) | 18.2 ± 0.84 | 11.3 ± 0.68 | 21.1 ± 0.2 | 16.3 ± 0.09 | 22 ± 0.1 |
Geotrichumcandidum (RCMB 052006) | 18.9 ±0.35 | 12.6 ±0.54 | 19.3 ± 0.05 | 15.4 ± 0.1 | 26 ± 0.3 |
Syncephalastrum racemosum (RCMB 005003) | 11.2 ± 0.44 | NA | 16.4 ± 0.08 | 14.2 ± 0.05 | 19 ± 0.1 |
Candida albicans (RCMB 005002) | NA | NA | NA | NA | 24 ± 0.1 |
Gram-positive Bacteria | Penicillin G | ||||
Staphylococcus aureus (RCMB 000106) (MSSA) | 17.8 ± 0.58 | 10.7 ± 0.36 | 21.4 ± .03 | 17.9 ± 0.03 | 27.4 ± 0.08 |
Bacillis subtilis (RCMB 000107) | 17.9 ± 0.46 | 11.1 ± 0.72 | 26.1 ± 0.04 | 15.2 ± 0.04 | 28.6 ± 0.03 |
Gram-negative Bacteria | Streptomycin | ||||
Pseudomonas aeruginosa (RCMB 000102) | NA | NA | 19.9 ± 0.09 | NA | 26.3 ± 0.03 |
Escherichia coli (RCMB 000103) | 12.6 ± 0.57 | 12.4 ±0.04 | 17.2 ± 0.2 | 13.4 ± 0.04 | 30.1 ± 0.07 |
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Kheder, N.A. Hydrazonoyl Chlorides as Precursors for Synthesis of Novel Bis-Pyrrole Derivatives. Molecules 2016, 21, 326. https://doi.org/10.3390/molecules21030326
Kheder NA. Hydrazonoyl Chlorides as Precursors for Synthesis of Novel Bis-Pyrrole Derivatives. Molecules. 2016; 21(3):326. https://doi.org/10.3390/molecules21030326
Chicago/Turabian StyleKheder, Nabila Abdelshafy. 2016. "Hydrazonoyl Chlorides as Precursors for Synthesis of Novel Bis-Pyrrole Derivatives" Molecules 21, no. 3: 326. https://doi.org/10.3390/molecules21030326