A New Indole Alkaloid from the Toad Venom of Bufo bufo gargarizans
Abstract
:1. Introduction
2. Results and Discussion
2.1. Structure Elucidation
2.2. Cytotoxic Activities
3. Experimental Section
3.1. General Information
3.2. Materials
3.3. Extraction, Isolation and Characterization
3.4. Acid Hydrolysis of Compound 1
3.5. HPLC Analysis
3.6. Cytotoxic Assays
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Position | δC, Type | δH (J in Hz) | HMBC a |
---|---|---|---|
2 | 123.3, CH | 7.11, s | 3, 8, 9, 10, 11 |
3 | 111.1, C | ||
4 | 102.3, CH | 7.00, d (2.1) | 3, 5, 8 |
5 | 149.4, C | ||
6 | 111.2, CH | 6.75, dd (2.1, 8.7) | 4, 5, 8 |
7 | 111.6, CH | 7.30, d (8.7) | 4, 5, 9 |
8 | 131.6, C | ||
9 | 128.0, C | ||
10 | 24.8, CH2 | 2.81, t (6.8) | 2, 3, 11, 13 |
11 | 40.1, CH2 | 3.36, t (6.8) | 3, 10, 13 |
13 | 173.5, C | ||
14 | 31.2, CH2 | 2.39, m | 16 |
15 | 31.1, CH2 | 2.39, m | 13 |
16 | 172.9, C | ||
18 | 54.3, CH | 4.07, dd (4.8, 8.3) | 16, 19, 20, 21 |
19 | 177.6, C | ||
20 | 29.5, CH2 | 1.56, m | 18, 19, 21, 22 |
1.71, m | |||
21 | 24.7, CH2 | 1.43, m | 18, 20, 22 |
22 | 40.7, CH2 | 2.99, t (6.9) | 20, 21, 24 |
24 | 157.0, C |
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Dai, Y.-H.; Shen, B.; Xia, M.-Y.; Wang, A.-D.; Chen, Y.-L.; Liu, D.-C.; Wang, D. A New Indole Alkaloid from the Toad Venom of Bufo bufo gargarizans. Molecules 2016, 21, 349. https://doi.org/10.3390/molecules21030349
Dai Y-H, Shen B, Xia M-Y, Wang A-D, Chen Y-L, Liu D-C, Wang D. A New Indole Alkaloid from the Toad Venom of Bufo bufo gargarizans. Molecules. 2016; 21(3):349. https://doi.org/10.3390/molecules21030349
Chicago/Turabian StyleDai, Ying-Hui, Bo Shen, Ming-Yu Xia, An-Dong Wang, Yu-Lin Chen, Dong-Chun Liu, and Dong Wang. 2016. "A New Indole Alkaloid from the Toad Venom of Bufo bufo gargarizans" Molecules 21, no. 3: 349. https://doi.org/10.3390/molecules21030349