Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives

Rioton, Sarah; Pardo, Domingo Gomez; Cossy, Janine

doi:10.3390/molecules22030483

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Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives

by

Sarah Rioton

,

Domingo Gomez Pardo

and

Janine Cossy

^*

Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI), CNRS UMR 8231, ESPCI Paris, PSL Research University, 10 rue Vauquelin, 75231 Paris CEDEX 05, France

^*

Author to whom correspondence should be addressed.

Molecules 2017, 22(3), 483; https://doi.org/10.3390/molecules22030483

Submission received: 2 March 2017 / Revised: 9 March 2017 / Accepted: 14 March 2017 / Published: 19 March 2017

(This article belongs to the Special Issue Women in Organic Chemistry)

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Abstract

A comprehensive survey of pathways leading to the generation of α-trifluoromethyl monocyclic piperidinic derivatives is provided (65 references). These compounds have been synthesized either from 6-membered rings e.g., pipecolic acid or lactam derivatives by introduction a trifluoromethyl group, from pyridine or pyridinone derivatives by reduction, and from 5-membered rings e.g., prolinol derivatives by ring expansion, from linear amines by cyclization or from dienes/dienophiles by [4 + 2]-cycloaddition.

Keywords: nitrogen heterocycles; fluorine; piperidine; trifluoromethyl group; ring expansion; cyclization; cycloaddition

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MDPI and ACS Style

Rioton, S.; Pardo, D.G.; Cossy, J. Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives. Molecules 2017, 22, 483. https://doi.org/10.3390/molecules22030483

AMA Style

Rioton S, Pardo DG, Cossy J. Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives. Molecules. 2017; 22(3):483. https://doi.org/10.3390/molecules22030483

Chicago/Turabian Style

Rioton, Sarah, Domingo Gomez Pardo, and Janine Cossy. 2017. "Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives" Molecules 22, no. 3: 483. https://doi.org/10.3390/molecules22030483

APA Style

Rioton, S., Pardo, D. G., & Cossy, J. (2017). Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives. Molecules, 22(3), 483. https://doi.org/10.3390/molecules22030483

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Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives

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