Targeted Magnetic Nanotheranostics of Cancer
Abstract
:1. Introduction
2. Aptamers
3. Characterization of Magnetic Nanoparticles
4. Production of Magnetic Nanoparticles
5. Coatings and Functionalization of MNPs
6. Application in Diagnostics
7. Magnetic Resonance Imaging
8. Application in Therapy
8.1. Chemotherapy or Drug Delivery
8.2. Magnetic Mediated Hyperthermia
8.3. Mechanical Destruction of Cells and Triggering of Apoptosis
9. Biodistribution and Toxicity of Gold and Magnetic Nanoparticles
10. Conclusions
Acknowledgments
Conflicts of Interest
References
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Materials | Size | Coatings | Antitumor Drugs | Linkers | Targeted Ligands | Applications | Reference |
---|---|---|---|---|---|---|---|
Gd-DTPA | 123.2 nm | Thermo-sensitive liposome (DPPC) | - | Carboxyl groups | Aptamers | MRI | [87] |
Iron oxide (magnetite) | 51.43 ± 4.52 nm | - | Epirubicin | Amine, carboxyl groups | Aptamers | Targeted chemotherapy MRI | [90] |
Iron oxide (magnetite) | 10 nm | - | Dextran | Thiol groups | Aptamers | Magnetic hyperthermia | [24] |
Iron oxide (magnetite) | 12 ± 3 nm | - | Doxorubicin | Thiol groups | Aptamers | Magnetic hyperthermia computed tomography | [22] |
Ironoxide (magnetite) | 15.4 nm | Gold Polyethylene-glycol | - | Amino and thiol groups | Aptamers | Targeted magnetic hyperthermia | [25] |
Nickel magnetic microdisks | 500 nm | Gold | - | Thiol groups | Aptamers | Mechanical destruction of cells and triggering of apoptosis | [116,118] |
Iron oxide (magnetite) | 50nm | Gold | - | Thiol groups | Aptamers | Apoptosis induction via fibronectin binding aptamers | [119] |
Iron-tagged single-walled carbon nanotubes | 200–300 nm | Polyvinyl-pyrrolidone | Doxorubicin | Carboxyl groups | Antibodies | Targeted chemotherapy MRI | [96] |
Ironoxide (magnetite) | 10 nm | Polyethylene-glycol | - | Carboxylate and Amino groups | Antibodies | Targeted therapy MRI | [92] |
Ironoxide (magnetite) | 40 nm | Chitosan and polyethylene-glycol | - | Amino and thiol groups | Antibodies | MRI | [86] |
Mn-Zn ferrite MNCs | 42.3nm | Polyethylene-glycol | - | Carboxyl groups | Сyclic tripeptide of arginine-glycine-aspartic acid | Targeted magnetic hyperthermia MRI | [17] |
Ironoxide (magnetite) | 5 nm | Lipid bilayer (DPPC/PEG750-PE) | Doxorubicin | - | - | Targeted chemotherapy controlled by electromagnetic fields | [101] |
Ironoxide (magnetite) | 6.8 nm | Gold | Doxorubicin | Cystmolecules | - | Chemotherapy magnetic hyperthermia combinatorial treatment | [23] |
Iron oxide (magnetite, maghemite) | 16.1 nm | Mesoporous silica | Doxorubicin | - | - | Targeted chemotherapy and magnetic hyperthermia | [26] |
Iron Oxide Nanocubes | 19 nm | Polyethylene-glycol | - | - | - | Magnetic hyperthermia MRI | [113] |
Ironoxide (magnetite) | 14 nm | Phospholipid-Polyethylene-glycol coating | Doxorubicin | - | - | Chemotherapy-magnetic hyperthermia combinatorial treatment | [112] |
Ironoxide (magnetite) | 5 nm | - | Cytostatic mitox-antrone | Phosphate groups | - | Targeted chemotherapy controlled by strong inhomogeneous magnetic field | [99] |
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Share and Cite
Belyanina, I.; Kolovskaya, O.; Zamay, S.; Gargaun, A.; Zamay, T.; Kichkailo, A. Targeted Magnetic Nanotheranostics of Cancer. Molecules 2017, 22, 975. https://doi.org/10.3390/molecules22060975
Belyanina I, Kolovskaya O, Zamay S, Gargaun A, Zamay T, Kichkailo A. Targeted Magnetic Nanotheranostics of Cancer. Molecules. 2017; 22(6):975. https://doi.org/10.3390/molecules22060975
Chicago/Turabian StyleBelyanina, Irina, Olga Kolovskaya, Sergey Zamay, Ana Gargaun, Tatiana Zamay, and Anna Kichkailo. 2017. "Targeted Magnetic Nanotheranostics of Cancer" Molecules 22, no. 6: 975. https://doi.org/10.3390/molecules22060975