Next Article in Journal
Ranatensin-HL: A Bombesin-Related Tridecapeptide from the Skin Secretion of the Broad-Folded Frog, Hylarana latouchii
Previous Article in Journal
Sites for Dynamic Protein-Carbohydrate Interactions of O- and C-Linked Mannosides on the E. coli FimH Adhesin
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 22
Issue 7
10.3390/molecules22071102
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Letter

A Novel Synthesis of 4-Acetoxyl 5(4H)-Oxazolones by Direct α-Oxidation of N-Benzoyl Amino-Acid Using Hypervalent Iodine

by
Gang Wen
,
Wen-Xuan Zhang
* and
Song Wu
*
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
*
Authors to whom correspondence should be addressed.
Molecules 2017, 22(7), 1102; https://doi.org/10.3390/molecules22071102
Submission received: 17 June 2017 / Revised: 27 June 2017 / Accepted: 29 June 2017 / Published: 3 July 2017
(This article belongs to the Section Organic Chemistry)
Browse Figures
Versions Notes

Abstract

We have developed a new method to prepare 4-acetoxy substituted 5(4H)-oxazolones by direct oxidation of N-benzoyl amino-acids using hypervalent iodine. The method is efficient, economical and easy to perform for the synthesis of quaternary substituted amino acid derivatives. We used online FTIR monitoring techniques to analyze the reaction, and gave a plausible reaction mechanism.
Keywords: oxidation; hypervalent iodine; 4-acetoxyl 5(4H)-oxazolones; N-benzoyl amino-acid; online FTIR oxidation; hypervalent iodine; 4-acetoxyl 5(4H)-oxazolones; N-benzoyl amino-acid; online FTIR
Graphical Abstract

Share and Cite

MDPI and ACS Style

Wen, G.; Zhang, W.-X.; Wu, S. A Novel Synthesis of 4-Acetoxyl 5(4H)-Oxazolones by Direct α-Oxidation of N-Benzoyl Amino-Acid Using Hypervalent Iodine. Molecules 2017, 22, 1102. https://doi.org/10.3390/molecules22071102

AMA Style

Wen G, Zhang W-X, Wu S. A Novel Synthesis of 4-Acetoxyl 5(4H)-Oxazolones by Direct α-Oxidation of N-Benzoyl Amino-Acid Using Hypervalent Iodine. Molecules. 2017; 22(7):1102. https://doi.org/10.3390/molecules22071102

Chicago/Turabian Style

Wen, Gang, Wen-Xuan Zhang, and Song Wu. 2017. "A Novel Synthesis of 4-Acetoxyl 5(4H)-Oxazolones by Direct α-Oxidation of N-Benzoyl Amino-Acid Using Hypervalent Iodine" Molecules 22, no. 7: 1102. https://doi.org/10.3390/molecules22071102

APA Style

Wen, G., Zhang, W.-X., & Wu, S. (2017). A Novel Synthesis of 4-Acetoxyl 5(4H)-Oxazolones by Direct α-Oxidation of N-Benzoyl Amino-Acid Using Hypervalent Iodine. Molecules, 22(7), 1102. https://doi.org/10.3390/molecules22071102

Article Metrics

Back to TopTop